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PROTAC ERRα Degrader-1

PROTAC ERRα Degrader-1 Structure
PROTAC ERRα Degrader-1 structure
CAS No.
2306388-84-9
Chemical Name:
PROTAC ERRα Degrader-1
Synonyms
PROTAC ERRα Degrader-1;1-Piperazineacetamide, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-N-[2-[[(2E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-1-oxo-2-propen-1-yl]amino]ethyl]-2-oxo-
CBNumber:
CB18054808
Molecular Formula:
C54H49Cl2F6N7O8
Molecular Weight:
1108.91
MDL Number:
MFCD32197286
MOL File:
2306388-84-9.mol
Last updated:2025-04-18 09:51:43
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PROTAC ERRα Degrader-1 Properties

Density 1.38±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 11.80±0.46(Predicted)
form Solid
color White to off-white

PROTAC ERRα Degrader-1 Chemical Properties,Uses,Production

Description

ERRα Degrader-1 is a Novel PROTAC Estrogen-related Receptor α (ERRα) Degrader.

Uses

PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an PROTAC estrogen-related receptor alpha (ERRa) degrader[1].

IC 50

ERRα; MDM2

References

[1] Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10(5):767-772. DOI:10.1021/acsmedchemlett.9b00025

PROTAC ERRα Degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC ERRα Degrader-1 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32433 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7781 56
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1608 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29757 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 trendseenbio@gmail.com China 9069 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 6051 58
Adooq Bioscience LLC 400-025-6535 sales@adooq.cn China 6215 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Jilin Province Woda Biotechnology Co., Ltd. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
Adooq Bioscience LLC 58

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PROTAC ERRα Degrader-1 1-Piperazineacetamide, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-N-[2-[[(2E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-1-oxo-2-propen-1-yl]amino]ethyl]-2-oxo- 2306388-84-9