PF-07104091
- CAS No.
- 2460249-19-6
- Chemical Name:
- PF-07104091
- Synonyms
- PF-07104091;PF7104091;PF 7104091;PF-7104091;Tagtociclib (PF-07104091);PF07104091, 10 mM in DMSO;(1R,3S)-3-(5-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-3-yl)cyclopentyl isopropylcarbamate;(1R,3S)-3-{5-[3-(methoxymethyl)-1-methyl-1H-pyrazole-5-amido]-1H-pyrazol-3-yl}cyclopentyl N-(propan-2-yl)carbamate;(1R,3S)-3-(3-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-5-yl)cyclopentyl isopropylcarbamate;(1R,3S)-3-[3-[[5-(methoxymethyl)-2-methyl-pyrazole-3-carbonyl]amino]-1H-pyrazol-5-yl]cyclopentyl] N-isopropylcarbamate
- CBNumber:
- CB18097593
- Molecular Formula:
- C19H28N6O4
- Molecular Weight:
- 404.47
- MDL Number:
- MFCD34471025
- MOL File:
- 2460249-19-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 567.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml |
| pka | 12.51±0.46(Predicted) |
| InChIKey | MTNBRBDFNSGQKB-DCHPQEBHNA-N |
| SMILES | N(C1NN=C([C@H]2CC[C@@H](OC(=O)NC(C)C)C2)C=1)C(C1N(N=C(COC)C=1)C)=O |&1:5,8,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
PF-07104091 Chemical Properties,Uses,Production
Uses
PF-07104091 can be used to treat advanced solid tumors, especially hormone receptor-positive (HR+)/HER2-negative breast cancer that is resistant to CDK4/6 inhibitors.
Description
PF-07104091 is an inhibitor of cyclin-dependent kinase 2 (Cdk2; Ki = 1.16 nM).1 It is selective for Cdk2 over glycogen synthase kinase 3β (GSK3β; Ki = 537.81 nM). PF-07104091 decreases proliferation of TOV-21G and OVCAR-3 ovarian and HCT116 colorectal cancer cells (IC50s = 4.8, 0.59, and 0.88 µM, respectively).2 In vivo, PF-07104091 (50 mg/kg per day) reduces tumor volume and weight in an HCT116 mouse xenograft model.WARNING This product is not for human or veterinary use.
References
[1] JUN TANG . Anilinopyrazole as selective CDK2 inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13 18: Pages 2985-2988. DOI: 10.1016/s0960-894x(03)00630-9
[2] LIU Z, YANG Y, SUN X, et al. Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53[J]. Molecules, 2024, 33 1. DOI: 10.3390/molecules29030725
PF-07104091 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-07104091 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8614 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10000 | 58 |
| Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 450 | 58 |
| ChemOrigin Pharm | 021-15026428026 15026428026 | ChemOrigin@126.com | China | 1023 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6003 | 61 |
View Lastest Price from PF-07104091 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | PF07104091
2460249-19-6
|
US $372.00-867.00 / mg | 99.59% | 10g | TargetMol Chemicals Inc. |
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- PF07104091
2460249-19-6
- US $372.00-867.00 / mg
- 99.59%
- TargetMol Chemicals Inc.
