PF-07104091
- CAS No.
- 2460249-19-6
- Chemical Name:
- PF-07104091
- Synonyms
- PF-07104091;Tagtociclib (PF-07104091);(1R,3S)-3-{5-[3-(methoxymethyl)-1-methyl-1H-pyrazole-5-amido]-1H-pyrazol-3-yl}cyclopentyl N-(propan-2-yl)carbamate;(1R,3S)-3-(3-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-5-yl)cyclopentyl isopropylcarbamate;PF7104091;PF-7104091;PF 7104091;PF07104091, 10 mM in DMSO;(1R,3S)-3-(5-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-3-yl)cyclopentyl isopropylcarbamate;(1R,3S)-3-[3-[[5-(methoxymethyl)-2-methyl-pyrazole-3-carbonyl]amino]-1H-pyrazol-5-yl]cyclopentyl] N-isopropylcarbamate
- CBNumber:
- CB18097593
- Molecular Formula:
- C19H28N6O4
- Molecular Weight:
- 404.47
- MDL Number:
- MFCD34471025
- MOL File:
- 2460249-19-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 567.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml |
| pka | 12.51±0.46(Predicted) |
| InChIKey | MTNBRBDFNSGQKB-DCHPQEBHNA-N |
| SMILES | N(C1NN=C([C@H]2CC[C@@H](OC(=O)NC(C)C)C2)C=1)C(C1N(N=C(COC)C=1)C)=O |&1:5,8,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
PF-07104091 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41356 | PF-07104091 ≥95% | 2460249-19-6 | 1mg | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 41356 | PF-07104091 ≥95% | 2460249-19-6 | 5mg | $273 | 2026-04-30 | Buy |
| Cayman Chemical | 41356 | PF-07104091 ≥95% | 2460249-19-6 | 10mg | $484 | 2026-04-30 | Buy |
| Cayman Chemical | 41356 | PF-07104091 ≥95% | 2460249-19-6 | 25mg | $984 | 2026-04-30 | Buy |
| Biosynth | KYD24919 | PF-07104091 | 2460249-19-6 | 10mg | $825 | 2026-06-04 | Buy |
PF-07104091 Chemical Properties, Uses, Production
Uses
PF-07104091 can be used to treat advanced solid tumors, especially hormone receptor-positive (HR+)/HER2-negative breast cancer that is resistant to CDK4/6 inhibitors.
Description
PF-07104091 is an inhibitor of cyclin-dependent kinase 2 (Cdk2; Ki = 1.16 nM).1 It is selective for Cdk2 over glycogen synthase kinase 3β (GSK3β; Ki = 537.81 nM). PF-07104091 decreases proliferation of TOV-21G and OVCAR-3 ovarian and HCT116 colorectal cancer cells (IC50s = 4.8, 0.59, and 0.88 µM, respectively).2 In vivo, PF-07104091 (50 mg/kg per day) reduces tumor volume and weight in an HCT116 mouse xenograft model.WARNING This product is not for human or veterinary use.
References
[1] JUN TANG . Anilinopyrazole as selective CDK2 inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13 18: Pages 2985-2988. DOI: 10.1016/s0960-894x(03)00630-9
[2] LIU Z, YANG Y, SUN X, et al. Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53[J]. Molecules, 2024, 33 1. DOI: 10.3390/molecules29030725
PF-07104091 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-07104091 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 473 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai PharmaPartner Co., Ltd. | 19983777532 | pharmabridge@163.com | China | 500 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Yunpun industrial Co.,Ltd | 21-61726900 15202122459; | sales@yunpun.com | China | 497 | 58 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8696 | 58 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
View Latest Price from PF-07104091 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-31 | PF07104091
2460249-19-6
|
$131.00-340.00 | 99.59% | 10g | TargetMol Chemicals Inc. |
-
- PF07104091
2460249-19-6
- $131.00-340.00
- 99.59%
- TargetMol Chemicals Inc.
