ChemicalBook >> CAS DataBase List >>3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]-

3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]-

CAS No.: 2417089-74-6

Chemical Name:: 3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]-

Synonyms: XL177A;XL177A ，S8967;XL177A, 10 mM in DMSO;MCF7,XL177A,Deubiquitinase,inhibit,Inhibitor,cancer,XL-177A,DUBs,p53,USP7;3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]-;3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-5-(phenylmethyl)pentyl]-

CBNumber:: CB18179015

Molecular Formula:: C48H57ClN8O5

Molecular Weight:: 861.47

MDL Number:: MFCD34179073

MOL File:: 2417089-74-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-11 16:31:51

Product description	Number	Pack Size	Price
XL177A ≥98% (HPLC)	SML3044	5MG	$271
XL177A ≥98% (HPLC)	SML3044	25MG	$873
XL177A	SWD08974	10mg	$776.2
XL177A	SWD08974	25mg	$1455.5
XL177A	SWD08974	50mg	$2025

Request For Quotation

3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- Properties

Density	1.35±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (58.04 mM; Need ultrasonic)
pka	13.61±0.20(Predicted)
form	Solid
color	Off-white to light yellow
InChIKey	UYJWYMWIVMCGQZ-DHUJRADRSA-N
SMILES	O=C1N(CC2(O)CCN(C([C@H](CC3=CC=CC=C3)CCCNC(C4=CC(N=C(CCCC5)C5=C6Cl)=C6C=C4)=O)=O)CC2)C=NC7=CC(NC(CCN8CCN(C)CC8)=O)=CC=C71
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3044	XL177A ≥98% (HPLC)	2417089-74-6	5MG	$271	2026-04-30	Buy
Sigma-Aldrich	SML3044	XL177A ≥98% (HPLC)	2417089-74-6	25MG	$873	2026-04-30	Buy
Biosynth	SWD08974	XL177A	2417089-74-6	10mg	$776.2	2026-06-05	Buy
Biosynth	SWD08974	XL177A	2417089-74-6	25mg	$1455.5	2026-06-05	Buy
Biosynth	SWD08974	XL177A	2417089-74-6	50mg	$2025	2026-06-05	Buy

Product number	Packaging	Price	Buy
SML3044	5MG	$271	Buy
SML3044	25MG	$873	Buy
SWD08974	10mg	$776.2	Buy
SWD08974	25mg	$1455.5	Buy
SWD08974	50mg	$2025	Buy

3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- Chemical Properties,Uses,Production

Uses

XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34nM. XL177A elicits cancer cell killing through a p53-dependent mechanism[1].

Biological Activity

XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. XL177A elicits cancer cell killing through a p53-dependent mechanism[1]. XL177A is a potent USP7 inhibitor and p53 stabilizer in cyto. XL177A suppresses cancer cell growth predominantly through a p53-dependent mechanism. XL177A labels the catalytic cysteine, C223, of USP7 with exquisite selectivity for USP7 across the DUBome and human proteome[1]. XL177A (1 μM) induces complete G1 arrest in MCF7 cells after 24 hours[1].Treatment of MCF7 cells, which express WT TP53, with XL177A (0.001- 10 μM) induces rapid degradation of HDM2 within 2 hours, followed by increases in p53 and downstream p21 protein levels[1].

References

[1]. Nathan J Schauer, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep.2020 Mar 24;10(1):5324.

3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- Suppliers

Global( 35)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4841	55
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	89686	60
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 18101056239	3193328036@qq.com	China	29660	68
Beyond Pharmaceutical Co., Ltd	0571-81953185 +86-15381198709	jasonyao@bydpharma.com	China	851	60

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shenzhen Shengda Pharma Limited	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
ShangHai Biochempartner Co.,Ltd	62
Beijing Solarbio Science & Tecnology Co., Ltd.	68
Beyond Pharmaceutical Co., Ltd	60

View Lastest Price from 3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	XL177A 2417089-74-6	$97.00-313.00		99.49%	10g	TargetMol Chemicals Inc.

XL177A
2417089-74-6
$97.00-313.00
99.49%
TargetMol Chemicals Inc.

3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- Spectrum

2417089-74-6(3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]-)Related Search:

XL 228 XL-019 XL413 (hydrochloride) XL-388 BMS-908662

XL888 XL765 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate

1of2

3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- XL177A 3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-5-(phenylmethyl)pentyl]- MCF7,XL177A,Deubiquitinase,inhibit,Inhibitor,cancer,XL-177A,DUBs,p53,USP7 XL177A, 10 mM in DMSO XL177A ，S8967 2417089-74-6 C48H57ClN8O5