2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)-
![2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)- Structure](CAS/20200611/GIF/2227368-54-7.gif)
- CAS No.
- 2227368-54-7
- Chemical Name:
- 2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)-
- Synonyms
- JH-X-119-01;JH-X-119-01 ，S9780;JH-X-119-01, 10 mM in DMSO;N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-3-yl)picolinamide;2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)-;inhibit,MYD88,IRAK,IL-1R associated kinase,Waldenstr?m,Inhibitor,IRAK1,Interleukin-1 receptor associated kinase,JHX11901,Diffused Large B-cell Lymphoma,JH X 119 01,macroglobulinemia
- CBNumber:
- CB18214965
- Molecular Formula:
- C25H20N6O3
- Molecular Weight:
- 452.46
- MDL Number:
- MFCD34593626
- MOL File:
- 2227368-54-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| JH-X-119-01 ≥95% | 43041 | 5mg | $99 |
| JH-X-119-01 ≥95% | 43041 | 10mg | $189 |
| JH-X-119-01 ≥95% | 43041 | 25mg | $372 |
| JH-X-119-01 ≥95% | 43041 | 50mg | $693 |
| JH-X-119-01 99.03% | CS-0226551 | 5mg | $195 |
2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)- Properties
| Boiling point | 654.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.405±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 250 mg/mL (552.54 mM; Need ultrasonic) |
| pka | 10.98±0.70(Predicted) |
| form | Solid |
| color | Light yellow to brown |
2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 43041 | JH-X-119-01 ≥95% | 2227368-54-7 | 5mg | $99 | 2026-04-30 | Buy |
| Cayman Chemical | 43041 | JH-X-119-01 ≥95% | 2227368-54-7 | 10mg | $189 | 2026-04-30 | Buy |
| Cayman Chemical | 43041 | JH-X-119-01 ≥95% | 2227368-54-7 | 25mg | $372 | 2026-04-30 | Buy |
| Cayman Chemical | 43041 | JH-X-119-01 ≥95% | 2227368-54-7 | 50mg | $693 | 2026-04-30 | Buy |
| ChemScene | CS-0226551 | JH-X-119-01 99.03% | 2227368-54-7 | 5mg | $195 | 2026-06-04 | Buy |
2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)- Chemical Properties,Uses,Production
Uses
JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice[1]. JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC50 of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM[2].
in vivo
JH-X-119-01 improves survival and decreases immunopathies of LPS-challenged mice. JH-X-119-01 increases survival of mice at the dose of 5 mg/kg body weight. Survival is further improved when the dose is increased to 10 mg/kg[1].
| Animal Model: | C57BL/6 (20-22 g, male) mice[1] |
| Dosage: | 5 mg/kg and 10 mg/kg |
| Administration: | Intraperitoneally injected; 5 days |
| Result: | Protected mice from LPS (20 mg/kg)-induced sepsis. Survival at day 5 was 13.3% in control group where septic mice were treated by vehicle, while the values were 37.5% and 56.3% for 5 mg/kg and 10 mg/kg. |
IC 50
IRAK-1: 9 nM (IC50)
References
[1] Bin Pan, et al. Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice. Int Immunopharmacol. 2020 Aug;85:106597. DOI:10.1016/j.intimp.2020.106597
[2] John M Hatcher, et al. Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma. ACS Med Chem Lett. 2020 Oct 9;11(11):2238-2243. DOI:10.1021/acsmedchemlett.0c00378
2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9945 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3504 | 58 |
View Lastest Price from 2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-10 | JH-X-119-01
2227368-54-7
|
$60.00-147.00 | 98.42% | 10g | TargetMol Chemicals Inc. |
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- JH-X-119-01
2227368-54-7
- $60.00-147.00
- 98.42%
- TargetMol Chemicals Inc.
