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JH-II-127

JH-II-127 structure

CAS No.: 1700693-08-8

Chemical Name:: JH-II-127

Synonyms: JH-II-127;JH-II-127, 10 mM in DMSO;2-anilino-4-methylamino-5-chloropyrrolopyrimidine;2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127;(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi;(4-((5-chloro-4-(methylamino)-3h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone;[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone;Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-

CBNumber:: CB43049255

Molecular Formula:: C19H21ClN6O3

Molecular Weight:: 416.86

MDL Number:: MFCD28975160

MOL File:: 1700693-08-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-17 09:03:53

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JH-II-127 Properties

Melting point	>166°C (dec.)
Density	1.458±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
pka	12.49±0.50(Predicted)
form	Solid
color	White to Pale Beige
InChI	1S/C19H21ClN6O3/c1-21-16-15-12(20)10-22-17(15)25-19(24-16)23-13-4-3-11(9-14(13)28-2)18(27)26-5-7-29-8-6-26/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24,25)
InChIKey	HUEKBQXFNHWTQQ-UHFFFAOYSA-N
SMILES	Clc1c2c(nc([nH]c2NC)Nc3c(cc(cc3)C(=O)N4CCOCC4)OC)nc1
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P261-P305+P351+P338
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

JH-II-127 price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML2569	JH-II-127 ≥98% (HPLC)	1700693-08-8	5MG	$115	2026-04-30	Buy
Sigma-Aldrich	SML2569	JH-II-127 ≥98% (HPLC)	1700693-08-8	25MG	$371	2026-04-30	Buy
Cayman Chemical	22905	JH-II-127 ≥98%	1700693-08-8	1mg	$36	2026-04-30	Buy
Cayman Chemical	22905	JH-II-127 ≥98%	1700693-08-8	5mg	$153	2026-04-30	Buy
Cayman Chemical	22905	JH-II-127 ≥98%	1700693-08-8	10mg	$268	2026-04-30	Buy

Product number	Packaging	Price	Buy
SML2569	5MG	$115	Buy
SML2569	25MG	$371	Buy
22905	1mg	$36	Buy
22905	5mg	$153	Buy
22905	10mg	$268	Buy

JH-II-127 Chemical Properties, Uses, Production

Description

JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC₅₀s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC₅₀ = 3,080 nM). JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2^G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.

Uses

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.

in vivo

JH-II-127 (100 mg/kg; i.p.; single) results in near complete dephosphorylation of Ser935 of LRRK2 in all tissues including brain^[1].

1.19Pharmacokinetic Parameters of JH-II-127 in Wild type male C57BL/6 mice^[1].

matrix	route	T_max (h)	C₀/C_max (ng/mL)	AUC_Last (hng/mL)	AUG_INF (hng/mL)	T_1/2 (h)	CL (mL/min/kg)	V_ss (L/kg)
plasma	IV (2 mg/kg)	-	1604.47	532.67	535.57	0.66	62.24	1.73
plasma	PO (10 mg/kg)	1	802.72	3094.58	3867.07	-	-	-
brain	IV (2 mg/kg)	-	1343.6	239.31	246.47	0.23	135.24	1.7
brain	PO (10 mg/kg)	1	247.35	688.21	762.38	-	-	-

Animal Model:	Wild type male C57BL/6 mice^[1].
Dosage:	2 mg/kg (for i.v.); 10 mg/kg (for p.o.); 10, 30, 100 mg/kg (for i.p.)
Administration:	Intravenous and intraperitoneal injection; oral administration; single.
Result:	Led to near complete dephosphorylation of Ser935 of LRRK2 in all tissues including brain when at 100 mg/kg of i.p. and near complete inhibition in all tissues at 30 mg/kg but only partial inhibition in brain at the 10 mg/kg dose. Demonstrated good oral bioavailability.

storage

Store at -20°C

References

[1] JOHN M. HATCHER. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor[J]. ACS Medicinal Chemistry Letters, 2015, 6 5: 584-589. DOI: 10.1021/acsmedchemlett.5b00064

JH-II-127 Preparation Products And Raw materials

Raw materials

Preparation Products

JH-II-127 Suppliers

Global Suppliers ( 89)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
UHN Shanghai Research & Development Co., Ltd.	021-58958002 18930822973	sales@uhnshanghai.com	China	997	58
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4860	55
Shanghaizehan biopharma technology co., Ltd.	021-61350663 13052117465	sales@zehanbiopharma.com	China	989	55
ShangHai Siyan Biological Technology Co., Ltd.	021-50908862，442785678，326799392 18721037013	siyansales@126.com	China	9612	58
Guangzhou QiYun Biotechnology Co., Ltd.	020-61288194 61288195	505721671@qq.com	China	3853	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
BOC Sciences	65
Haoyuan Chemexpress Co., Ltd.	61
UHN Shanghai Research & Development Co., Ltd.	58
AdooQ Bioscience CHINA	60
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghaizehan biopharma technology co., Ltd.	55
ShangHai Siyan Biological Technology Co., Ltd.	58
Guangzhou QiYun Biotechnology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60

View Latest Price from JH-II-127 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-17	JH-II-127 1700693-08-8	$64.00-178.00		98.32%	10g	TargetMol Chemicals Inc.
	2019-12-27	JH-II-127 1700693-08-8	$1.00	1KG	97%-99.9%	100kg	Career Henan Chemical Co

JH-II-127
1700693-08-8
$64.00-178.00
98.32%
TargetMol Chemicals Inc.

JH-II-127
1700693-08-8
$1.00
97%-99.9%
Career Henan Chemical Co

JH-II-127 Spectrum

JH-II-127(1700693-08-8)¹HNMR

1700693-08-8 (JH-II-127) Related Search:

[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone JH-II-127 2-Pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)- XMD17 109 N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide

GNE-9605

1of2

JH-II-127 (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi (4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 2-anilino-4-methylamino-5-chloropyrrolopyrimidine 2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127 [4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl- [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone HEK293,JHII127,3T3 cells,Inhibitor,LRRK2-G2019S,Ser935,Leucine-rich repeat kinase 2,LRRK2,parkinson’s disease,inhibit,JH II 127,LRRK2-A2016T JH-II-127, 10 mM in DMSO (4-((5-chloro-4-(methylamino)-3h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 1700693-08-8