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ChemicalBook >> CAS DataBase List >>1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- Structure
1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- structure
CAS No.
2364554-48-1
Chemical Name:
1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-
Synonyms
Aficamten;CK-274;CK-3773274;(R)-N-(5-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide;Afkeitai;Aficamten(CK274);Aficamten (CK-3773274;Aficamten, 10 mM in DMSO;Aficamten (CK-274) ，E1016;1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-
CBNumber:
CB18366125
Molecular Formula:
C18H19N5O2
Molecular Weight:
337.38
MDL Number:
MOL File:
2364554-48-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-23 14:48:42
Request For Quotation

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- Properties

Density 1.40±0.1 g/cm3(Predicted)
solubility DMSO : 125 mg/mL (370.50 mM; Need ultrasonic)
form A crystalline solid
pka 13.84±0.20(Predicted)
color White to light brown
InChI InChI=1S/C18H19N5O2/c1-3-16-21-17(22-25-16)12-4-6-14-11(8-12)5-7-15(14)20-18(24)13-9-19-23(2)10-13/h4,6,8-10,15H,3,5,7H2,1-2H3,(H,20,24)/t15-/m1/s1
InChIKey IOVAZWDIRCRMTM-OAHLLOKOSA-N
SMILES N1(C)C=C(C(N[C@H]2C3=C(C=C(C4N=C(CC)ON=4)C=C3)CC2)=O)C=N1
FDA UNII B1I77MH6K1

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 36304 Aficamten ≥95% 2364554-48-1 1mg $106 2026-04-30 Buy
Cayman Chemical 36304 Aficamten ≥95% 2364554-48-1 5mg $395 2026-04-30 Buy
Cayman Chemical 36304 Aficamten ≥95% 2364554-48-1 10mg $685 2026-04-30 Buy
ChemScene CS-0202223 Aficamten 99.86% 2364554-48-1 5mg $217 2026-06-04 Buy
ChemScene CS-0202223 Aficamten 99.86% 2364554-48-1 10mg $303 2026-06-04 Buy
Product number Packaging Price Buy
36304 1mg $106 Buy
36304 5mg $395 Buy
36304 10mg $685 Buy
CS-0202223 5mg $217 Buy
CS-0202223 10mg $303 Buy

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- Chemical Properties,Uses,Production

Uses

Aficamten can be useful in the study of myosin modulation in cardiovascular medicine.

in vivo

Aficamten is a next-generation cardiac myosin inhibitor that provides a projected human half-life appropriate for once a day dosing, reaching steady state within two weeks, and demonstrates a wide therapeutic window in vivo with a clear PK/PD relationship[1].
Aficamten exhibits moderate oral bioavailability (mouse 98%, rat 55%, rat 58%,rat 79%, dog 45%, monkey 41%) following oral administration (mouse 1 mg/kg, rat 2 mg/kg, rat 3 mg/kg, rat 8 mg/kg, dog 1 mg/kg and monkey 1 mg/kg)[1].
Aficamten exhibits terminal elimination half-lives (mouse 4.5 h, rat 3.0 h, dog 33.8 h and, monkey 8.1 h) following intravenous administration (mouse 0.5 mg/kg, rat 1 mg/kg, dog 1 mg/kg and monkey 1.0 mg/kg)[1].

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- Suppliers

Global( 80)Suppliers
Supplier Tel Email Country ProdList Advantage
Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd 19066311943 815989315@qq.com China 925 58
Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. 13771642864 snhuyu_2008@126.com China 1187 58
Elucigen bio 13501719342 13501719342 wayne.zheng@elucigenbio.com China 5000 58
Wuhan HSN Pharmaresearch CO., LTD. 027-81525288 18086100502 linwell@126.com China 383 50
Zhengzhou Runkai Pharmaceutical Technology Co., Ltd 19137644811 3649307081@qq.com China 496 58
Hangzhou Yinghui Industrial Co.,Ltd +86-15355417531 +86-15355417531 2028755477@qq.com China 499 58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Hygeia (Chengdu) pharmaceutical technique Co., Ltd 028-84502008 13568869383 sales@hygeiapharm.com China 291 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd 58
Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. 58
Elucigen bio 58
Wuhan HSN Pharmaresearch CO., LTD. 50
Zhengzhou Runkai Pharmaceutical Technology Co., Ltd 58
Hangzhou Yinghui Industrial Co.,Ltd 58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Hygeia (Chengdu) pharmaceutical technique Co., Ltd 55
Bide Pharmatech Ltd. 60

View Lastest Price from 1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- pictures 2026-07-24 1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-
2364554-48-1
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
Aficamten pictures 2026-07-17 Aficamten
2364554-48-1
 $68.00-228.00 99.57% 10g TargetMol Chemicals Inc.
  • Aficamten pictures
  • Aficamten
    2364554-48-1
  • $68.00-228.00
  • 99.57%
  • TargetMol Chemicals Inc.

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- Spectrum

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-(2364554-48-1)1HNMR

2364554-48-1(1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-)Related Search:

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- GITOXIN Mavacamten DIGOXIN 3β,5,14-Trihydroxy-5β-bufa-20,22-dienolide
DIGITOXIGENIN

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1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- Aficamten (CK-3773274 CK3773274,CK-3773274,cardiac,CK-274,Myosin,cardiomyopathy,Inhibitor,CK 3773274,CK 274,hypertrophic,inhibit,Aficamten,CK274,HCM Aficamten(CK274) Aficamten, 10 mM in DMSO Aficamten (CK-274) ，E1016 Afkeitai (R)-N-(5-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide Aficamten CK-274 CK-3773274 2364554-48-1 Aficamten