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ChemicalBook >> CAS DataBase List >>7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate

7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate

7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Structure
7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate structure
CAS No.
158876-66-5
Chemical Name:
7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate
Synonyms
FR 167653;FR 167653 sulfate;7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate
CBNumber:
CB1840319
Molecular Formula:
C24H20FN5O6S
Molecular Weight:
525.51
MDL Number:
MFCD00932388
MOL File:
158876-66-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:50:06
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7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color Light yellow to yellow

7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0014258 FR 167653 99.87% 158876-66-5 5mg $672 2026-06-04 Buy
ChemScene CS-0014258 FR 167653 99.87% 158876-66-5 10mg $1137 2026-06-04 Buy
ChemScene CS-0014258 FR 167653 99.87% 158876-66-5 25mg $2437 2026-06-04 Buy
ChemScene CS-0014258 FR 167653 99.87% 158876-66-5 50mg $3900 2026-06-04 Buy
ChemScene CS-0014258 FR 167653 99.87% 158876-66-5 100mg $6283 2026-06-04 Buy
Product number Packaging Price Buy
CS-0014258 5mg $672 Buy
CS-0014258 10mg $1137 Buy
CS-0014258 25mg $2437 Buy
CS-0014258 50mg $3900 Buy
CS-0014258 100mg $6283 Buy

7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Chemical Properties,Uses,Production

Uses

FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo[1][2][3].

in vivo

FR 167653 (FR 167653 sulfate) (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis[1].

Animal Model:Inbred male Balbuc mice (aged 8 weeks)[1]
Dosage:32 kg/mg
Administration:Subcutaneous injection; 24-48 hours
Result:The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla.

References

[1] Furuichi K, et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant. 2002 Mar;17(3):399-407. DOI:10.1093/ndt/17.3.399
[2] Iwata Y, et al. p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol. 2003 Jan;14(1):57-67. DOI:10.1097/01.asn.0000037402.83851.5f
[3] Kawashima Y, et al. FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38mitogen-activated protein kinase. J Heart Lung Transplant. 2001 May;20(5):568-74. DOI:10.1016/s1053-2498(01)00243-1

7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Nantong Hi-Future Biotechnology Co., Ltd +86-0513; 18051384581 sales@chemhifuture.com China 3075 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
Aladdin Scientific tp@aladdinsci.com United States 50089 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Fan De(Beijing) Biotechnology Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
cjbscvictory 58
Nantong Hi-Future Biotechnology Co., Ltd 58
RD International Technology Co., Limited 58
Aladdin Scientific 58

7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Spectrum

7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE(158876-66-5)MS7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE(158876-66-5)1HNMR7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE(158876-66-5)13CNMR7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE(158876-66-5)IR1

158876-66-5(7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate)Related Search:

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FR 167653 FR 167653 sulfate 7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate 158876-66-5 C24H18FN5O2H2O4S