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4-Bromo-6-fluoroquinoline

4-Bromo-6-fluoroquinoline Structure
4-Bromo-6-fluoroquinoline structure
CAS No.
661463-17-8
Chemical Name:
4-Bromo-6-fluoroquinoline
Synonyms
4-Bromo-6-fluoroquinoline;Quinoline, 4-bromo-6-fluoro-
CBNumber:
CB1948011
Molecular Formula:
C9H5BrFN
Molecular Weight:
226.05
MDL Number:
MFCD09261094
MOL File:
661463-17-8.mol
MSDS File:
SDS
Last updated:2026-05-27 23:51:29
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4-Bromo-6-fluoroquinoline Properties

Boiling point 299.7±20.0 °C(Predicted)
Density 1.647±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form solid
pka 2.71±0.16(Predicted)
Appearance Colorless to yellow Solid
InChI 1S/C9H5BrFN/c10-8-3-4-12-9-2-1-6(11)5-7(8)9/h1-5H
InChIKey HIWPTYUKGHNQCU-UHFFFAOYSA-N
SMILES Fc1ccc2nccc(Br)c2c1
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-41
Safety Statements  26-39
WGK Germany  3
HS Code  2933499090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1

4-Bromo-6-fluoroquinoline price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich BBO000278 4-Bromo-6-fluoroquinoline Aldrich 661463-17-8 1g $379 2026-04-30 Buy
Apolloscientific PC404567 4-Bromo-6-fluoroquinoline 98% 661463-17-8 250mg $21 2026-06-04 Buy
Apolloscientific PC404567 4-Bromo-6-fluoroquinoline 98% 661463-17-8 1g $32 2026-06-04 Buy
Apolloscientific PC404567 4-Bromo-6-fluoroquinoline 98% 661463-17-8 5g $94 2026-06-04 Buy
Apolloscientific PC404567 4-Bromo-6-fluoroquinoline 98% 661463-17-8 25g $459 2026-06-04 Buy
Product number Packaging Price Buy
BBO000278 1g $379 Buy
PC404567 250mg $21 Buy
PC404567 1g $32 Buy
PC404567 5g $94 Buy
PC404567 25g $459 Buy

4-Bromo-6-fluoroquinoline Chemical Properties, Uses, Production

Synthesis

6-FLUORO-4-HYDROXYQUINOLINE

391-78-6

4-Bromo-6-fluoroquinoline

661463-17-8

General procedure for the synthesis of 4-bromo-6-fluoroquinoline from 4-hydroxy-6-fluoroquinoline: To a solution of 4-hydroxy-6-fluoroquinoline (20 g, 122.58 mmol) in DMF (130 mL) heated to 60 °C was slowly added phosphorus tribromide (13 mL, 1.15 equiv.). The reaction mixture was heated at 45 °C with stirring for 45 min. After the reaction was completed, it was cooled to room temperature and the reaction solution was diluted with water (200 mL). Subsequently, Na2CO3 was slowly added until the pH of the reaction solution reached 10. The precipitated solid product was collected by filtration. The solid was dissolved in ethyl acetate (200 mL) and the solution was concentrated to dryness. The residue was purified by column chromatography (eluent: ethyl acetate) to afford the target product 4-bromo-6-fluoroquinoline as a pale yellow solid (22 g, 79% yield).1H NMR (CDCl3) δ: 8.70 (d, J = 4.7 Hz, 1H); 8.14 (m, 1H); 7.96 (d, J = 4.7 Hz, 1H); 7.81-7.73 (m 2H).

References

[1] Patent: WO2008/152603, 2008, A1. Location in patent: Page/Page column 36
[2] Patent: WO2017/21319, 2017, A1. Location in patent: Page/Page column 32

4-Bromo-6-fluoroquinoline Preparation Products And Raw materials

Raw materials

6-Fluoro-4-hydroxyquinoline 6-Fluoro-4-hydroxyquinoline N,N-Dimethylformamide Phosphorus tribromide

Preparation Products

4-Bromo-6-fluoroquinoline Suppliers

Global Suppliers ( 93)
Supplier Tel Email Country ProdList Advantage
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Wuhan ariel chemical Co., LTD. 18986259541 18986259541 sales@3stc.com China 3821 58
Chengdu Forest Science and Technology Development Co., Ltd. 18030648795 18030648795 sales@cdforestchem.com China 1998 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
Wuhan Kaymke Chemical Co., Ltd., 027-87342388 18086026008 sales@kaymke.com China 3536 55
Suzhou Sino Rare Chemical Co., Ltd. 0512-62857507 sales@sinorarechem.com China 999 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Suzhou Laing Biological Technology Co., LTD 0512-62968256 18550502935 export@laingbiotec.com China 992 58
Shanghai AQBioPharma Co., Ltd. 13661411401 yinglv.que@aqbiopharma.com.cn China 2976 58
Supplier Advantage
Shanghai Hanhong Scientific Co.,Ltd. 64
Wuhan ariel chemical Co., LTD. 58
Chengdu Forest Science and Technology Development Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
Wuhan Kaymke Chemical Co., Ltd., 55
Suzhou Sino Rare Chemical Co., Ltd. 58
Bide Pharmatech Ltd. 60
Suzhou Laing Biological Technology Co., LTD 58
Shanghai AQBioPharma Co., Ltd. 58

View Latest Price from 4-Bromo-6-fluoroquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Bromo-6-fluoroquinoline pictures 2026-08-25 4-Bromo-6-fluoroquinoline
661463-17-8
 $1.10-9.90 1KG 99% min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
4-Bromo-6-fluoroquinoline pictures 2020-01-08 4-Bromo-6-fluoroquinoline
661463-17-8
 $1.00 1KG 99.0% 100kg Career Henan Chemical Co

4-Bromo-6-fluoroquinoline Spectrum

4-Bromo-6-fluoroquinoline(661463-17-8)1HNMR

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4-Bromo-6-fluoroquinoline Quinoline, 4-bromo-6-fluoro- 661463-17-8 86195-53-5