6-Fluoro-4-hydroxyquinoline
- CAS No.
- 391-78-6
- Chemical Name:
- 6-Fluoro-4-hydroxyquinoline
- Synonyms
- BUTTPARK 13\01-64;6-FLUOROQUINOLIN-4-OL;4-Quinolinol, 6-fluoro-;6-FLUORO-4(1H)-QUINOLINONE;6-fluoro-1H-quinolin-4-one;6-Fluoro-4-hydroxyquinoline;4-HYDROXY-6-FLUOROQUINOLINE
- CBNumber:
- CB5453850
- Molecular Formula:
- C9H6FNO
- Molecular Weight:
- 163.15
- MDL Number:
- MFCD00269610
- MOL File:
- 391-78-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 221-223℃ |
|---|---|
| Boiling point | 317℃ |
| Density | 1.366 |
| Flash point | 145℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| pka | 4.07±0.40(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C9H6FNO/c10-6-1-2-8-7(5-6)9(12)3-4-11-8/h1-5H,(H,11,12) |
| InChIKey | BYZXOYSEYWCLOK-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC(F)=CC=2)C(O)=CC=1 |
| CAS DataBase Reference | 391-78-6(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P261-P271 |
| Hazard Codes | Xi |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 2933491090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
6-Fluoro-4-hydroxyquinoline price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | JRD0180 | 6-Fluoroquinolin-4-ol AldrichCPR | 391-78-6 | 1 g | $230 | 2026-04-30 | Buy |
| Biosynth | AAA39178 | 6-Fluoroquinolin-4-ol | 391-78-6 | 50g | $625 | 2026-06-04 | Buy |
| Apolloscientific | PC8235 | 6-Fluoro-4-hydroxyquinoline 98% | 391-78-6 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC8235 | 6-Fluoro-4-hydroxyquinoline 98% | 391-78-6 | 5g | $74 | 2026-06-04 | Buy |
| Apolloscientific | PC8235 | 6-Fluoro-4-hydroxyquinoline 98% | 391-78-6 | 10g | $143 | 2026-06-04 | Buy |
6-Fluoro-4-hydroxyquinoline Chemical Properties,Uses,Production
Synthesis
2033-24-1
371-40-4
391-78-6
GENERAL STEPS: To a solution of 4-fluoroaniline (3.03 mL, 31.5 mmol, 1.0 eq.) in ethanol (30 mL) was added cyclic (sub)isopropyl malonate (Meldrum acid, 5.54 g, 38.4 mmol, 1.2 eq.) and triethyl orthoformate (12.4 mL, 74.5 mmol, 2.4 eq.), in that order. The reaction mixture was heated to reflux for 2.5 hours. Upon completion of the reaction, the mixture was cooled to 0 °C, the precipitated solid was collected by filtration and washed with cold ethanol. The dried solid was quickly added to boiling diphenyl ether (100 mL) and the reflux state was maintained for 3 minutes. Subsequently, the reaction mixture was stirred at room temperature for 30 min, petroleum ether (25 mL) was added to promote product precipitation, and the solid was collected by filtration and dried. The crude product was purified by silica gel column chromatography (eluent: EtOAc/MeOH, 95:5, v/v) to afford the target compound 6-fluoroquinolin-4-ol (2.36 g, 14.5 mmol, 46% yield). The product was analyzed (TLC, 1H NMR, 13C NMR, IR, LC-MS, HRMS and melting point determination) and confirmed to be consistent with the data reported in the literature. Ref: WO2010/123995 (2010).TLC Rf 0.41 (EtOAc/MeOH 95:5).1H NMR (400 MHz, DMSO-d6) δ (ppm): 11.90 (s, 1H, OH), 7.94 (d, J = 7.6 Hz, 1H, NCH), 7.73 (m, 1H, NCCH), 7.53 (m, 1H, NCCH). NCCH), 7.53-7.67 (m, 2H, FCCH), 6.04 (d, J = 7.3 Hz, 1H, OHCCH).13C NMR (101 MHz, DMSO-d6) δ (ppm): 159.9, 157.7, 140.0, 137.2, 127.3, 121.1, 120.8, 109.5, 108.3. 108.3. IR (neat) νmax: 2768 (br), 1594 (m) cm1. LC-MS (ESI+) m/z: 164.1 [M + H]+, 186.1 [M + Na]+. HRMS (ESI+) m/z: Calculated value 164.0506, measured value 164.0509 [M + H]+. Melting point: 227-228 °C.
References
[1] Patent: WO2017/21319, 2017, A1. Location in patent: Page/Page column 31
[2] Patent: WO2008/152603, 2008, A1. Location in patent: Page/Page column 36
6-Fluoro-4-hydroxyquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Xinda Biotechnology Co., Ltd | 0519-85519868 18915088878 | xiaoweng106108@163.com | China | 99 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Changzhou Wanyao Biotechnology Co., Ltd. | 0519-89185693 15312551983 | 2410037592@qq.com | China | 278 | 55 |
View Lastest Price from 6-Fluoro-4-hydroxyquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 4-Hydroxy-6-fluoroquinoline
391-78-6
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2020-01-13 | 6-FLUORO-4-HYDROXYQUINOLINE
391-78-6
|
$5.50 | 1KG | 98%min | 1kg-100kg | Career Henan Chemical Co |
-
- 4-Hydroxy-6-fluoroquinoline
391-78-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 6-FLUORO-4-HYDROXYQUINOLINE
391-78-6
- $5.50
- 98%min
- Career Henan Chemical Co
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