tert-Butyl piperidine-4-carboxylate
- CAS No.
- 138007-24-6
- Chemical Name:
- tert-Butyl piperidine-4-carboxylate
- Synonyms
- tert-Butyl 4-Piperidinecarboxylate;Tert-Butyl Piperidine-4-Carboxylate;4-tert-butyl piperidine-4-carboxylate;4-Piperidine carboxylic acid t-butyl ester;4-Piperidinecarboxylic acid tert-butyl ester;Piperidine-4-carboxylic acid tert-butyl ester;4-Piperidinecarboxylic acid, 1,1-diMethylethyl ester;4-Piperidinecarboxylic acid tert-butyl ester hydrochloride
- CBNumber:
- CB1972058
- Molecular Formula:
- C10H19NO2
- Molecular Weight:
- 185.26
- MDL Number:
- MFCD02684429
- MOL File:
- 138007-24-6.mol
- MSDS File:
- SDS
| Boiling point | 241.0±33.0 °C(Predicted) |
|---|---|
| Density | 0.976±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 9.78±0.10(Predicted) |
| Appearance | Colorless to off-white Solid-Liquid Mixture |
| InChI | InChI=1S/C10H19NO2/c1-10(2,3)13-9(12)8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3 |
| InChIKey | FUYBPBOHNIHCHM-UHFFFAOYSA-N |
| SMILES | N1CCC(C(OC(C)(C)C)=O)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| HS Code | 2933399990 |
tert-Butyl piperidine-4-carboxylate price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B6957 | tert-Butyl Piperidine-4-carboxylate min. 98.0 % | 138007-24-6 | 5G | $72 | 2026-04-30 | Buy |
| TCI Chemical | B6957 | tert-Butyl Piperidine-4-carboxylate min. 98.0 % | 138007-24-6 | 25G | $210 | 2026-04-30 | Buy |
| Synthonix | P37700 | tert-Butyl piperidine-4-carboxylate 90+% | 138007-24-6 | 100mg | $10 | 2026-05-06 | Buy |
| Synthonix | P37700 | tert-Butyl piperidine-4-carboxylate 90+% | 138007-24-6 | 250mg | $16 | 2026-05-06 | Buy |
| Synthonix | P37700 | tert-Butyl piperidine-4-carboxylate 90+% | 138007-24-6 | 1g | $21 | 2026-05-06 | Buy |
tert-Butyl piperidine-4-carboxylate Chemical Properties, Uses, Production
Synthesis
882738-24-1
138007-24-6
Wet Degussa-type Pd/C catalyst (10% Pd, 50% water content, 8.120 g, 76.30 mmol) was added to a 3 L three-necked flask under nitrogen protection, followed by EtOAc (1.706 L). The mixture was degassed by a nitrogen/vacuum cycle (3 times). Then, a solution of EtOAc (243.7 mL) of 1-benzyl-4-tert-butylpiperidine-1,4-dicarboxylate (243.7 g, 763.0 mmol) was added. The reaction mixture was stirred overnight under hydrogen atmosphere. After supplementing with hydrogen, stirring was continued for 3.5 hours. Methanol (60 mL) was added to promote dissolution of the precipitate, which was subsequently filtered through a diatomaceous earth pad and washed with methanol. The filtrate was concentrated under reduced pressure to give a brown oil (138.6 g) containing a small amount of white solid. The solid was removed by filtration and washed with a minimal amount of EtOAc. The filtrate was again concentrated under reduced pressure to give tert-butyl piperidine-4-carboxylate (129 g, 91% yield) as a light brown oil. The product was characterized by 1H NMR (500 MHz, DMSO-d6) with chemical shifts of δ 2.88 (dt, 2H), 2.44 (td, 2H), 2.23 (tt, 1H), 1.69-1.64 (m, 2H), 1.41-1.33 (m, 11H).
References
[1] Patent: US2015/158872, 2015, A1. Location in patent: Paragraph 0508; 0510
[2] Patent: WO2006/38039, 2006, A1. Location in patent: Page/Page column 17; 29
[3] Patent: WO2015/65866, 2015, A1. Location in patent: Page/Page column 32
tert-Butyl piperidine-4-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Sheepchem Co., Ltd. | +86 (21) 6715-7650 | sheepchem@163.com | China | 993 | 60 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
View Latest Price from tert-Butyl piperidine-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 4-Piperidinecarboxylicacidt-butylesterHCl
138007-24-6
|
$5.50 | 1KG | 98%min | 1kg-100kg | Career Henan Chemical Co |
-
- 4-Piperidinecarboxylicacidt-butylesterHCl
138007-24-6
- $5.50
- 98%min
- Career Henan Chemical Co
