1-Boc-piperidine
- CAS No.
- 75844-69-8
- Chemical Name:
- 1-Boc-piperidine
- Synonyms
- tert-butyl piperidine-1-carboxylate;N-BOC-PIPERIDINE;1-BOC-PIPERIDINE;1-Boc-Piperidine,98%;N-Boc-tetrahydropyridine;1-(tert-Butoxycarbonyl)piperidine;N-(TERT-BUTOXYCARBONYL)PIPERIDINE;tert-Butyl 1-piperidinecarboxylate;1-(tert-Butyloxycarbonyl)piperidine;1-(tert-Butoxycarbonyl)piperidine >
- CBNumber:
- CB7348312
- Molecular Formula:
- C10H19NO2
- Molecular Weight:
- 185.26
- MDL Number:
- MFCD02093935
- MOL File:
- 75844-69-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 130-140°C 15mm |
|---|---|
| Density | 0.964 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 188 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | Liquid |
| pka | -1.28±0.20(Predicted) |
| color | Clear colorless to pale yellow |
| BRN | 3604898 |
| CAS DataBase Reference | 75844-69-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335-H400-H227 | |||||||||
| Precautionary statements | P210e-P280a-P370+P378a-P403+P235-P501a-P261-P273-P301+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T,N,Xi | |||||||||
| Risk Statements | 25-36/37/38-50 | |||||||||
| Safety Statements | 26-36-45-60-61 | |||||||||
| RIDADR | UN 2810 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
1-Boc-piperidine price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4625 | 1-(tert-Butoxycarbonyl)piperidine >98.0%(GC) | 75844-69-8 | 5g | $37 | 2026-04-30 | Buy |
| TCI Chemical | B4625 | 1-(tert-Butoxycarbonyl)piperidine >98.0%(GC) | 75844-69-8 | 25g | $121 | 2026-04-30 | Buy |
| Apolloscientific | OR909204 | tert-Butyl piperidine-1-carboxylate >97% | 75844-69-8 | 25g | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR909204 | tert-Butyl piperidine-1-carboxylate >97% | 75844-69-8 | 100g | $101 | 2026-06-04 | Buy |
| Apolloscientific | OR909204 | tert-Butyl piperidine-1-carboxylate >97% | 75844-69-8 | 500g | $425 | 2026-06-04 | Buy |
1-Boc-piperidine Chemical Properties, Uses, Production
Chemical Properties
Colorless liquid
Synthesis
110-89-4
24424-99-5
75844-69-8
The general procedure for the synthesis of tert-butyl piperidine-1-carboxylate from hexahydropyridine and di-tert-butyl dicarbonate is as follows: hexahydropyridine (1 mmol) was added to a solution of ethanol (1 mL) containing magnetically stirred guanidine hydrochloride (15 mol%) and di-tert-butyl dicarbonate (1.2 mmol) and the reaction was stirred to completion at 35-40 °C (reaction progress was monitored by TLC or GC). Upon completion of the reaction, the ethanol is evaporated under vacuum and the residue is washed with water to remove the catalyst or dissolved in dichloromethane (or ethyl acetate) and filtered to separate the catalyst. If an organic solvent is used for post-treatment, the product is almost pure after evaporation of the organic solvent. If excess di-tert-butyl dicarbonate is used, the product can be washed with petroleum ether or hexane to recover the residual di-tert-butyl dicarbonate. If necessary, the product can be further purified by crystallization (using hexane and dichloromethane, or ether and petroleum ether as solvents) or silica gel column chromatography (ethyl acetate-hexane (1:6) as eluent).
References
[1] Synthesis, 2006, # 16, p. 2784 - 2788
[2] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322
[3] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[4] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[5] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1035 - 1043
1-Boc-piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Sichuan Guanghan Bio-Tech Co., Ltd | +86-28-86127071 | info@sino-produce.com | China | 400 | 66 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 1-Boc-piperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 1-Boc-piperidine
75844-69-8
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 1-Boc-piperidine
75844-69-8
- $1.00
- 99%
- Career Henan Chemical Co
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