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ChemicalBook >> CAS DataBase List >>Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Structure
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) structure
CAS No.
265108-36-9
Chemical Name:
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
Synonyms
4,4-difluorocyclohexane-1-carbaldehyde;4,4-Difluoro-cyclohexanecarbaldehyde;4,4-Difluoro Cyclohexanecarboxaldehyde;4,4-DIFLU0R0 CYCLOHEXANECARBOXALDEHYDE;Cyclohexanecarboxaldehyde, 4,4-difluor;Cyclohexanecarboxaldehyde, 4,4-difluoro-;4,4-difluorocyclohexane-1-carbaldehyde 95%;Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
CBNumber:
CB21048522
Molecular Formula:
C7H10F2O
Molecular Weight:
148.15
MDL Number:
MFCD09263468
MOL File:
265108-36-9.mol
MSDS File:
SDS
Last updated:2026-07-16 16:37:17
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Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Properties

Boiling point 165.0±40.0 °C(Predicted)
Density 1.10±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
form solid
Appearance Colorless to light yellow Liquid
InChI InChI=1S/C7H10F2O/c8-7(9)3-1-6(5-10)2-4-7/h5-6H,1-4H2
InChIKey DNSDOTKSZMHDOR-UHFFFAOYSA-N
SMILES C1(C=O)CCC(F)(F)CC1
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315
Precautionary statements  P264-P270-P280-P301+P312-P302+P352-P332+P313
Hazard Codes  Xi
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  2913000090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Skin Irrit. 2

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich MNO000202 4,4-Difluorocyclohexanecarboxaldehyde 265108-36-9 1g $454 2026-04-30 Buy
Biosynth FD104547 4,4-difluorocyclohexane-1-carbaldehyde 265108-36-9 2g $900 2026-06-04 Buy
Biosynth FD104547 4,4-difluorocyclohexane-1-carbaldehyde 265108-36-9 1g $900 2026-06-04 Buy
Biosynth FD104547 4,4-difluorocyclohexane-1-carbaldehyde 265108-36-9 0.5g $900 2026-06-04 Buy
Biosynth FD104547 4,4-difluorocyclohexane-1-carbaldehyde 265108-36-9 0.25g $900 2026-06-04 Buy
Product number Packaging Price Buy
MNO000202 1g $454 Buy
FD104547 2g $900 Buy
FD104547 1g $900 Buy
FD104547 0.5g $900 Buy
FD104547 0.25g $900 Buy

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Chemical Properties,Uses,Production

Uses

4,4-Difluorocyclohexanecarbaldehyde is used in the preparation of heteroaryl acid derivative and methods for treating oxalate-related diseases.

Synthesis

Cyclohexanemethanol, 4,4-difluoro- (9CI)

178312-48-6

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)

265108-36-9

Oxalyl chloride (0.35 mL, 4.16 mmol) was dissolved in anhydrous dichloromethane (15.0 mL) under nitrogen protection and cooled to -78 °C. Subsequently, dimethyl sulfoxide (0.27 mL, 3.84 mmol) was slowly added dropwise and stirred at -78 °C for 15 min. Next, a solution of (4,4-difluorocyclohexyl)methanol (0.48 g, 3.20 mmol) in anhydrous dichloromethane (10 mL) was added dropwise. The reaction mixture was continued to be stirred at -78 °C for 1 hour. After that, triethylamine (1.27 mL, 9.60 mmol) was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and subsequently concentrated to dryness under reduced pressure. The crude product was dissolved in ether (30 mL) and washed sequentially with saturated aqueous sodium bicarbonate solution and ammonium chloride solution (30 mL each). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4,4-difluorocyclohexanecarboxaldehyde (0.39 g, 82% yield), which could be used in subsequent reactions without further purification.1H NMR (DMSO-d6) δ: 9.61 (s, 1H), 2.05-1.73 (m, 7H), 1.64-1.51 (m, 2H).

References

[1] Patent: WO2014/144836, 2014, A2. Location in patent: Paragraph 0095; 0996
[2] European Journal of Medicinal Chemistry, 2016, vol. 111, p. 138 - 159
[3] Patent: WO2014/184561, 2014, A1. Location in patent: Page/Page column 72
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2780 - 2789
[5] Patent: WO2009/65035, 2009, A1. Location in patent: Page/Page column 81-82

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Preparation Products And Raw materials

Raw materials

Ethyl 4,4-difluorocyclohexanecarboxylate Cyclohexanemethanol, 4,4-difluoro- (9CI) Triethylamine Dichloromethane Dimethyl sulfoxide
Oxalyl chloride

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Preparation Products

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Suppliers

Global( 102)Suppliers
Supplier Tel Email Country ProdList Advantage
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 3014 58
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9336 55
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Supplier Advantage
Cochemical Ltd. 58
Energy Chemical 61
Aikon International Limited 58
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Hangzhou Sage Chemical Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
SynAsst Chemical. 55
Shanghai Raise Chemical Technology Co.,Ltd 55

View Lastest Price from Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) pictures 2026-07-16 Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
265108-36-9
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) pictures 2021-07-13 Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
265108-36-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) pictures 2021-07-10 Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
265108-36-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Spectrum

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)(265108-36-9)1HNMR

265108-36-9(Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI))Related Search:

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Ethyl 4,4-difluorocyclohexanecarboxylate Perfluorocyclohexanecarboxylic acid Perfluorocyclohexanecarbonyl bromide Cyclohexanecarboxaldehyde 4,4-difluoroadamantane-1-carboxylic acid
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Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) 4,4-Difluoro Cyclohexanecarboxaldehyde Cyclohexanecarboxaldehyde, 4,4-difluoro- Cyclohexanecarboxaldehyde, 4,4-difluor 4,4-DIFLU0R0 CYCLOHEXANECARBOXALDEHYDE 4,4-difluorocyclohexane-1-carbaldehyde 95% 4,4-difluorocyclohexane-1-carbaldehyde 4,4-Difluoro-cyclohexanecarbaldehyde 265108-36-9 C7H10F2O HALIDE ALDEHYDE