Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
- CAS No.
- 265108-36-9
- Chemical Name:
- Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
- Synonyms
- 4,4-difluorocyclohexane-1-carbaldehyde;4,4-Difluoro-cyclohexanecarbaldehyde;4,4-Difluoro Cyclohexanecarboxaldehyde;4,4-DIFLU0R0 CYCLOHEXANECARBOXALDEHYDE;Cyclohexanecarboxaldehyde, 4,4-difluor;Cyclohexanecarboxaldehyde, 4,4-difluoro-;4,4-difluorocyclohexane-1-carbaldehyde 95%;Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
- CBNumber:
- CB21048522
- Molecular Formula:
- C7H10F2O
- Molecular Weight:
- 148.15
- MDL Number:
- MFCD09263468
- MOL File:
- 265108-36-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4,4-Difluorocyclohexanecarboxaldehyde | MNO000202 | 1g | $454 |
| 4,4-difluorocyclohexane-1-carbaldehyde | FD104547 | 2g | $900 |
| 4,4-difluorocyclohexane-1-carbaldehyde | FD104547 | 1g | $900 |
| 4,4-difluorocyclohexane-1-carbaldehyde | FD104547 | 0.5g | $900 |
| 4,4-difluorocyclohexane-1-carbaldehyde | FD104547 | 0.25g | $900 |
| More product size | |||
| Boiling point | 165.0±40.0 °C(Predicted) |
|---|---|
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | solid |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C7H10F2O/c8-7(9)3-1-6(5-10)2-4-7/h5-6H,1-4H2 |
| InChIKey | DNSDOTKSZMHDOR-UHFFFAOYSA-N |
| SMILES | C1(C=O)CCC(F)(F)CC1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315 |
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P332+P313 |
| Hazard Codes | Xi |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 2913000090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Skin Irrit. 2 |
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | MNO000202 | 4,4-Difluorocyclohexanecarboxaldehyde | 265108-36-9 | 1g | $454 | 2026-04-30 | Buy |
| Biosynth | FD104547 | 4,4-difluorocyclohexane-1-carbaldehyde | 265108-36-9 | 2g | $900 | 2026-06-04 | Buy |
| Biosynth | FD104547 | 4,4-difluorocyclohexane-1-carbaldehyde | 265108-36-9 | 1g | $900 | 2026-06-04 | Buy |
| Biosynth | FD104547 | 4,4-difluorocyclohexane-1-carbaldehyde | 265108-36-9 | 0.5g | $900 | 2026-06-04 | Buy |
| Biosynth | FD104547 | 4,4-difluorocyclohexane-1-carbaldehyde | 265108-36-9 | 0.25g | $900 | 2026-06-04 | Buy |
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Chemical Properties,Uses,Production
Uses
4,4-Difluorocyclohexanecarbaldehyde is used in the preparation of heteroaryl acid derivative and methods for treating oxalate-related diseases.
Synthesis
178312-48-6
265108-36-9
Oxalyl chloride (0.35 mL, 4.16 mmol) was dissolved in anhydrous dichloromethane (15.0 mL) under nitrogen protection and cooled to -78 °C. Subsequently, dimethyl sulfoxide (0.27 mL, 3.84 mmol) was slowly added dropwise and stirred at -78 °C for 15 min. Next, a solution of (4,4-difluorocyclohexyl)methanol (0.48 g, 3.20 mmol) in anhydrous dichloromethane (10 mL) was added dropwise. The reaction mixture was continued to be stirred at -78 °C for 1 hour. After that, triethylamine (1.27 mL, 9.60 mmol) was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and subsequently concentrated to dryness under reduced pressure. The crude product was dissolved in ether (30 mL) and washed sequentially with saturated aqueous sodium bicarbonate solution and ammonium chloride solution (30 mL each). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4,4-difluorocyclohexanecarboxaldehyde (0.39 g, 82% yield), which could be used in subsequent reactions without further purification.1H NMR (DMSO-d6) δ: 9.61 (s, 1H), 2.05-1.73 (m, 7H), 1.64-1.51 (m, 2H).
References
[1] Patent: WO2014/144836, 2014, A2. Location in patent: Paragraph 0095; 0996
[2] European Journal of Medicinal Chemistry, 2016, vol. 111, p. 138 - 159
[3] Patent: WO2014/184561, 2014, A1. Location in patent: Page/Page column 72
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2780 - 2789
[5] Patent: WO2009/65035, 2009, A1. Location in patent: Page/Page column 81-82
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9065 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
265108-36-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
265108-36-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-02-05 | Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
265108-36-9
|
$3.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
265108-36-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
265108-36-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
265108-36-9
- $3.00
- 98%
- Career Henan Chemical Co
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