Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI)
![Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) Structure](CAS/GIF/167216-17-3.gif)
- CAS No.
- 167216-17-3
- Chemical Name:
- Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- Boc-(R)-3-aminobutan-1-ol;(R)-N-BOC-3-AMINOBUTAN-1-OL;N-Boc-(R)-3-aminobutan-1-ol;N-(t-Butoxycarbonyl)-L-β-homoalaninol;(R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate;tert-Butyl (R)-(4-hydroxybutan-2-yl)carbamate;tert-butyl N-[(1R)-3-hydroxy-1-methyl-propyl]carbamate;(-)-tert-butyl [(R)-3-hydroxy-1-methylpropyl]carbamate;Carbamic acid, N-[(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester;Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI)
- CBNumber:
- CB21072347
- Molecular Formula:
- C9H19NO3
- Molecular Weight:
- 189.25
- MDL Number:
- MFCD18831346
- MOL File:
- 167216-17-3.mol
- MSDS File:
- SDS
| Boiling point | 301.4±25.0 °C(Predicted) |
|---|---|
| Density | 1.010±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 12.32±0.46(Predicted) |
| Appearance | White to off-white Solid |
| optical activity | Consistent with structure |
| InChI | InChI=1S/C9H19NO3/c1-7(5-6-11)10-8(12)13-9(2,3)4/h7,11H,5-6H2,1-4H3,(H,10,12)/t7-/m1/s1 |
| InChIKey | JSZOAOLSEKSNTD-SSDOTTSWSA-N |
| SMILES | C(OC(C)(C)C)(=O)N[C@H](C)CCO |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 308519 | (R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate | 167216-17-3 | 1.00g | $58 | 2026-05-19 | Buy |
| Matrix Scientific | 308519 | (R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate | 167216-17-3 | 5.00g | $82 | 2026-05-19 | Buy |
| Matrix Scientific | 308519 | (R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate | 167216-17-3 | 10.00g | $148 | 2026-05-19 | Buy |
| Synthonix | B50599 | (R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate 95+% | 167216-17-3 | 250mg | $54 | 2026-05-06 | Buy |
| Synthonix | B50599 | (R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate 95+% | 167216-17-3 | 1g | $60 | 2026-05-06 | Buy |
Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties, Uses, Production
Synthesis
159877-47-1
![Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI)](/CAS/GIF/167216-17-3.gif)
167216-17-3
General procedure for the synthesis of tert-butyl (R)-(4-hydroxybutan-2-yl)carbamate from methyl (R)-N-Boc-3-aminobutyrate: To a solution of methyl (R)-3-((tert-butoxycarbonyl)amino)butyrate (3.0 g, 14.76 mmol) in tetrahydrofuran (THF) (50 mL) was slowly added lithium aluminum (0.728 g, 19.19 mmol) hydroxide (0.728 g, 19.19 mmol) at -78°C under nitrogen protection. Lithium aluminum hydride (0.728 g, 19.19 mmol) was added slowly at -78°C under nitrogen protection. The reaction mixture was stirred at this temperature for 1 hour. Subsequently, the reaction system was slowly warmed to 0°C and the reaction was quenched by dropwise addition of water (0.7 mL) and 15% NaOH aqueous solution (0.7 mL). After quenching, the mixture was stirred at room temperature for 1 h and then filtered through a diatomaceous earth pad. The filtrate was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give tert-butyl (R)-(4-hydroxybutan-2-yl)carbamate (1.3 g).
References
[1] Advanced Synthesis and Catalysis, 2010, vol. 352, # 1, p. 92 - 96
[2] Patent: US2011/237814, 2011, A1. Location in patent: Page/Page column 11
[3] Patent: WO2014/114249, 2014, A1. Location in patent: Page/Page column 21
Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shijiazhuang Lickon PharmaTech Co., Ltd. | 031185291771 13832391721 | yaofeng2005@163.com | China | 947 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Nanjing Derno Pharmaceutical Technology Co., Ltd. | 02585057128;025-86957866 13952093866 | sales@dernopharm.com | China | 943 | 58 |
| Chengdu Chuangkecheng Biological Technology Co., Ltd. | 028-028-0000000 13008177686 | sales@ckcbiotech.com | China | 899 | 55 |
| Zhengzhou Alfachem Co.,Ltd. | 0371-53778726 18003825608 | liuxiaoyan@alfachem.cn | China | 1971 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from Carbamic acid, [(1R)-3-hydroxy-1-methylpropyl]-, 1,1-dimethylethyl ester (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-19 | (R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate
167216-17-3
|
1kg | 98.0% | 1000kg | Shanghai Joiny Pharmaceutical Co.,LTD |
-
- (R)-tert-Butyl (4-hydroxybutan-2-yl)carbamate
167216-17-3
- $0.00
- 98.0%
- Shanghai Joiny Pharmaceutical Co.,LTD
