(S)-3-Aminobutan-1ol
- CAS No.
- 61477-39-2
- Chemical Name:
- (S)-3-Aminobutan-1ol
- Synonyms
- (S)-3-Aminobutan-1ol;(S)-3-Amin-1-butanol;(S)-3-Aminopropan-1-ol;(3S)-3-Amino-1-butanol;(3S)-3-aminobutan-1-ol;(+)-(S)-3-aMinopropan-1-ol;1-Butanol, 3-amino-, (3S)-;(S)-3-Aminobutan-1-ol - [A10771];1-Fmoc-4-(Cbz-amino)piperidine-4-carboxylic acid
- CBNumber:
- CB31180140
- Molecular Formula:
- C4H11NO
- Molecular Weight:
- 89.14
- MDL Number:
- MFCD08275763
- MOL File:
- 61477-39-2.mol
- MSDS File:
- SDS
| Boiling point | 168℃ |
|---|---|
| Density | 0.927 |
| Flash point | 56℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Ethanol (Sparingly). Methanol (Slightly) |
| form | Oil |
| pka | 15.00±0.10(Predicted) |
| color | Colourless to Light Yellow |
| optical activity | Consistent with structure |
| InChI | 1S/C4H11NO/c1-4(5)2-3-6/h4,6H,2-3,5H2,1H3/t4-/m0/s1 |
| InChIKey | AGMZSYQMSHMXLT-BYPYZUCNSA-N |
| SMILES | C[C@H](N)CCO |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H318-H314 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P280-P305+P351+P338-P310 |
| RIDADR | 2735 |
| WGK Germany | WGK 3 |
| HazardClass | 8 |
| PackingGroup | Ⅲ |
| Storage Class | 11 - Combustible Solids |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
(S)-3-Aminobutan-1ol price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-A601888-5G | (S)-3-Aminobutan-1-ol | 61477-39-2 | 5g | $910 | 2026-06-03 | Buy |
| TRC | TRC-A601888-2.5G | (S)-3-Aminobutan-1-ol | 61477-39-2 | 2.5g | $581 | 2026-06-03 | Buy |
| TRC | TRC-A601888-100MG | (S)-3-Aminobutan-1-ol | 61477-39-2 | 100mg | $91 | 2026-06-03 | Buy |
| Matrix Scientific | 122035 | (S)-3-Aminobutan-1-ol | 61477-39-2 | 1.00g | $235 | 2026-05-18 | Buy |
| Matrix Scientific | 122035 | (S)-3-Aminobutan-1-ol | 61477-39-2 | 5.00g | $655 | 2026-05-18 | Buy |
(S)-3-Aminobutan-1ol Chemical Properties, Uses, Production
Chemical Properties
Colorless liquid
Uses
(S)-3-Aminobutan-1-ol can be used as an intermediate in the preparation of compounds having HIV integrase inhibitory activity.
Synthesis
168827-91-6
61477-39-2
General procedure for the synthesis of (S)-3-aminobutanol from (S)-benzyl(4-hydroxybutan-2-yl)carbamate: To a 1000 mL round bottom flask was added a solution of (S)-benzyl(4-hydroxybutan-2-yl)carbamate (30 g, 134.4 mmol, 1.00 eq.) in methanol (500 mL), followed by the addition of palladium carbon (3 g, 0.10 equivalent). The reaction mixture was stirred at 25 °C for 12 h under hydrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 11.7 g (92% yield) of (S)-3-aminobutan-1-ol as a colorless oil. The product was confirmed by 1H NMR (300 MHz, DMSO-d6, ppm): δ 4.48 (3H, s), 3.47 (2H, s), 2.96 (1H, s), 1.47-1.41 (2H, q), 1.02-0.99 (3H, d); the LCMS (ESI) analysis showed a m/z of 90 [M + H]+; the specific spectroscopy measurement value of [α]D22 +11.65° (c = 1.22 g/100 mL in EtOH) is consistent with the literature value of [α]D20 +16.3° (c = 4.5 in EtOH) (J. Org. Chem. 1996, 61, 2293-2304).
References
[1] Patent: WO2014/9447, 2014, A1. Location in patent: Page/Page column 96; 97
[2] Patent: WO2014/202741, 2014, A1. Location in patent: Page/Page column 42; 43
[3] Patent: US2015/197529, 2015, A1. Location in patent: Paragraph 1201; 1204
[4] Patent: US2016/168141, 2016, A1. Location in patent: Paragraph 1210; 1213
[5] Patent: WO2016/96936, 2016, A1. Location in patent: Page/Page column 43
(S)-3-Aminobutan-1ol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| The future of Shanghai Industrial Co., Ltd. | 021-61552785 | sales@shshiji.com | China | 9531 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
View Latest Price from (S)-3-Aminobutan-1ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-09 | (S)-3-Aminobutan-1ol
61477-39-2
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- (S)-3-Aminobutan-1ol
61477-39-2
- $8.80
- 97%-99%
- Career Henan Chemical Co
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