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3-Carboxy-4-octyl-2-methylenebutyrolactone

3-Carboxy-4-octyl-2-methylenebutyrolactone structure

CAS No.: 218137-86-1

Chemical Name:: 3-Carboxy-4-octyl-2-methylenebutyrolactone

Synonyms: C75;C75（218137-86-1）;C75, 10 mM in DMSO;C75 >=98% (HPLC), powder;FAS inhibitor C75 (C-75;3-Carboxy-4-octyl-2-methylenebutyrolactone;TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE;3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-;C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid);TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID

CBNumber:: CB2114165

Molecular Formula:: C14H22O4

Molecular Weight:: 254.32

MDL Number:: MFCD03265452

MOL File:: 218137-86-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:50:12

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3-Carboxy-4-octyl-2-methylenebutyrolactone Properties

Boiling point	432.1±45.0 °C(Predicted)
Density	1.08±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 18 mg/mL
form	solid
pka	3.08±0.40(Predicted)
color	off-white
InChI	1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)
InChIKey	VCWLZDVWHQVAJU-UHFFFAOYSA-N
SMILES	CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
FDA UNII	8E9A8CTX2H
UNSPSC Code	41121801
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

3-Carboxy-4-octyl-2-methylenebutyrolactone price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C5490	C75 ≥98% (HPLC), powder	218137-86-1	5mg	$399	2026-04-30	Buy
Sigma-Aldrich	C5490	C75 ≥98% (HPLC), powder	218137-86-1	25mg	$1530	2026-04-30	Buy
ChemScene	CS-3562	C75 99.91%	218137-86-1	5mg	$130	2026-06-04	Buy
ChemScene	CS-3562	C75 99.91%	218137-86-1	10mg	$216	2026-06-04	Buy
ChemScene	CS-3562	C75 99.91%	218137-86-1	25mg	$433	2026-06-04	Buy

Product number	Packaging	Price	Buy
C5490	5mg	$399	Buy
C5490	25mg	$1530	Buy
CS-3562	5mg	$130	Buy
CS-3562	10mg	$216	Buy
CS-3562	25mg	$433	Buy

3-Carboxy-4-octyl-2-methylenebutyrolactone Chemical Properties, Uses, Production

Uses

C75 has been used:

as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide

Definition

ChEBI: 4-methylene-2-octyl-5-oxo-3-oxolanecarboxylic acid is a gamma-lactone.

Biochem/physiol Actions

C75 helps to increase the cancer‐killing capability of ionizing radiation.

in vivo

C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection^[3]. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA^[4].

3-Carboxy-4-octyl-2-methylenebutyrolactone Preparation Products And Raw materials

Raw materials

Preparation Products

3-Carboxy-4-octyl-2-methylenebutyrolactone Suppliers

Global Suppliers ( 79)

Supplier	Tel	Email	Country	ProdList	Advantage
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD	13816107857	sales@fortunechem-sh.com	China	981	58
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
Jiaxing Novartis Chemical Co., Ltd.	18957373295		China	1579	58
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2374	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4859	55
Shanghaizehan biopharma technology co., Ltd.	021-61350663 13052117465	sales@zehanbiopharma.com	China	989	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58

Supplier	Advantage
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD	58
AdooQ BioScience, LLC	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Jiaxing Novartis Chemical Co., Ltd.	58
LETOPHARM LIMITED	58
Sigma-Aldrich	80
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghaizehan biopharma technology co., Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
Amadis Chemical Company Limited	58

View Latest Price from 3-Carboxy-4-octyl-2-methylenebutyrolactone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	C75 218137-86-1	$41.00-98.00		98.84%	10g	TargetMol Chemicals Inc.
2026-07-14	C75 218137-86-1	$41.00-98.00		98.84%	10g	TargetMol Chemicals Inc.
2026-06-30	3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE 218137-86-1		1KG	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd

C75
218137-86-1
$41.00-98.00
98.84%
TargetMol Chemicals Inc.

C75
218137-86-1
$41.00-98.00
98.84%
TargetMol Chemicals Inc.

3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
218137-86-1
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

3-Carboxy-4-octyl-2-methylenebutyrolactone Spectrum

3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE(218137-86-1)¹HNMR

218137-86-1 (3-Carboxy-4-octyl-2-methylenebutyrolactone) Related Search:

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1of4

C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid) TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID FAS inhibitor C75 (C-75 3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo- C75 >=98% (HPLC), powder C75, 10 mM in DMSO C75（218137-86-1） C75 3-Carboxy-4-octyl-2-methylenebutyrolactone 218137-86-1 Fatty acid synthase Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates D to K Enzyme Inhibitors Biochemicals and Reagents BioChemical