3-Fluoro-4-nitrobenzoic acid
- CAS No.
- 403-21-4
- Chemical Name:
- 3-Fluoro-4-nitrobenzoic acid
- Synonyms
- 3-FLUORO-4-NITROBENZENECARBOXYLIC ACID;BUTTPARK 32\01-75;3-Fluoro-4-nitrobenzoic;uoro-4-nitrobenzoic Acid;Tegoprazan Intermediate 1.3;3-FLUORO-4-NITROBENZONICACID;3-FLUORO-4-NITROBENZOIC ACID;3-FLUORO-4-NITROBENZOIC CAID;3-Fluoro-4-nitrobenzoicacid95%;3-Fluoro-4-nitrobenzoicacid99%
- CBNumber:
- CB9155507
- Molecular Formula:
- C7H4FNO4
- Molecular Weight:
- 185.11
- MDL Number:
- MFCD01862092
- MOL File:
- 403-21-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 174-175°C |
|---|---|
| Boiling point | 372.8±27.0 °C(Predicted) |
| Density | 1.568±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 3.08±0.10(Predicted) |
| color | White to Light yellow to Green |
| InChI | InChI=1S/C7H4FNO4/c8-5-3-4(7(10)11)1-2-6(5)9(12)13/h1-3H,(H,10,11) |
| InChIKey | WVZBIQSKLXJFNX-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C([N+]([O-])=O)C(F)=C1 |
| CAS DataBase Reference | 403-21-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-37/38-36-22 | |||||||||
| Safety Statements | 26-36/37/39-37 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
3-Fluoro-4-nitrobenzoic acid price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0670 | 3-Fluoro-4-nitrobenzoic Acid >98.0%(GC)(T) | 403-21-4 | 5g | $29 | 2026-04-30 | Buy |
| TCI Chemical | F0670 | 3-Fluoro-4-nitrobenzoic Acid >98.0%(GC)(T) | 403-21-4 | 25g | $115 | 2026-04-30 | Buy |
| AstaTech | CL4111 | 3-FLUORO-4-NITROBENZENECARBOXYLICACID 97% | 403-21-4 | 25G | $34 | 2026-04-30 | Buy |
| Biosynth | FF70536 | 3-Fluoro-4-nitrobenzoic acid | 403-21-4 | 250g | $650 | 2026-06-04 | Buy |
| Biosynth | FF70536 | 3-Fluoro-4-nitrobenzoic acid | 403-21-4 | 500g | $845 | 2026-06-04 | Buy |
3-Fluoro-4-nitrobenzoic acid Chemical Properties,Uses,Production
Uses
3-Fluoro-4-nitrobenzoic Acid is used in the synthesis of ABT-072, a non-nucleoside HCV NS5B polymerase inhibitor.
Synthesis
To a solution of 3-fluoro-4-nitrobenzyl alcohol (2.97 g) in acetone (60 ml) was added Jones reagent (13 ml), prepared from chromic acid (26.7 g) and sulfuric acid (23 ml) in water (100 ml), dropwise at 0°C. The mixture was stirred on a ice-bath for 0.5 h and quenched with isopropanol (20 ml) to be concentrated in vacuo. The residue was dissolved in ethyl acetate (30 ml) and washed with water (30 ml X 3), and brine (30 ml X 1), successively. The organic layer was dried over sodium sulfate and concentrated in vacuo to obtain a yellow solid, that was triturated with hexane. 3-fluoro-4-nitrobenzoic acid as a pale yellow solid (2.94 g, 92%).
References
[1] Patent: WO2009/130481, 2009, A1. Location in patent: Page/Page column 145
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 6, p. 1729 - 1744
[3] Patent: EP1820799, 2007, A1
[4] Patent: WO2006/51851, 2006, A1. Location in patent: Page/Page column 60-61
[5] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 5, p. 1386 - 1391
3-Fluoro-4-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anstar Chemical (Group) Co.,Ltd. | 18053179586 | export@anstarchemical.com | China | 698 | 58 |
| Shandong Elito Biotechnology Co., Ltd | 0539-18853986-090 13053958157 | 332554317@qq.com | China | 104 | 58 |
| FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID | 15940530539 15396717197 | 361811402@qq.com | China | 650 | 58 |
| Shanghai FWD Chemicals Limited | 021-544580828 021-54450828 | sales@fwdchem.com | China | 998 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from 3-Fluoro-4-nitrobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-27 | 3-Fluoro-4-nitrobenzoic acid
403-21-4
|
$10.00-30.00 | 50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2021-07-13 | 3-Fluoro-4-nitrobenzoic acid
403-21-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 3-Fluoro-4-nitrobenzoic acid
403-21-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3-Fluoro-4-nitrobenzoic acid
403-21-4
- $10.00-30.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Fluoro-4-nitrobenzoic acid
403-21-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-Fluoro-4-nitrobenzoic acid
403-21-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
403-21-4(3-Fluoro-4-nitrobenzoic acid)Related Search:
1of4
