Cyromazine
- CAS No.
- 66215-27-8
- Chemical Name:
- Cyromazine
- Synonyms
- CIROMAZIN;N-CYCLOPROPYL-1,3,5-TRIAZINE-2,4,6-TRIAMINE;CYROMAZIN;2-cyclopropylamino-4,6-diamino-s-triazine;N2-CYCLOPROPYL-1,3,5-TRIAZINE-2,4,6-TRIAMINE;ARMOR;neoprex;TRIGARD;NEPOREX;Neoprox
- CBNumber:
- CB2120418
- Molecular Formula:
- C6H10N6
- Molecular Weight:
- 166.18
- MDL Number:
- MFCD00078650
- MOL File:
- 66215-27-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 223-227 °C (lit.) |
|---|---|
| Boiling point | 284.39°C (rough estimate) |
| Density | 1.3196 (rough estimate) |
| vapor pressure | 4.5 x l0-7 Pa (25 °C) |
| refractive index | 1.8300 (estimate) |
| Flash point | 100 °C |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 5.2 (base) |
| Water Solubility | 13 g l-1 (pH 7.1,25 °C) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,2775 |
| BRN | 882879 |
| Henry's Law Constant | 1.7×108 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Stability | Hygroscopic |
| InChI | 1S/C6H10N6/c7-4-10-5(8)12-6(11-4)9-3-1-2-3/h3H,1-2H2,(H5,7,8,9,10,11,12) |
| InChIKey | LVQDKIWDGQRHTE-UHFFFAOYSA-N |
| SMILES | Nc1nc(N)nc(NC2CC2)n1 |
| LogP | -0.061 at 25℃ |
| CAS DataBase Reference | 66215-27-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | CA49Y29RA9 |
| NIST Chemistry Reference | Cyromazine(66215-27-8) |
| Pesticides Freedom of Information Act (FOIA) | Cyromazine |
| EPA Substance Registry System | Cyromazine (66215-27-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H411 | |||||||||
| Precautionary statements | P273-P391-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN3077 (solid) | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XZ1056500 | |||||||||
| HS Code | 29336990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Chronic 2 | |||||||||
| Hazardous Substances Data | 66215-27-8(Hazardous Substances Data) | |||||||||
| Toxicity | LC50 (96-hour) for rainbow trout and carp >100 mg/L and bluegill sunfish >90 mg/L (Hartley and Kidd, 1987); acute oral LD50 for rats 3,387 mg/kg (Hartley and Kidd, 1987) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Cyromazine price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2899 | Cyromazine pharmaceutical secondary standard, certified reference material | 66215-27-8 | 500MG | $200 | 2026-04-30 | Buy |
| Sigma-Aldrich | CRM07346 | Cyromazin certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | 66215-27-8 | 25 mg | $64.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 45414 | Cyromazin PESTANAL , analytical standard | 66215-27-8 | 50mg | $98.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1161203 | Cyromazin United States Pharmacopeia (USP) Reference Standard | 66215-27-8 | 200mg | $420 | 2026-04-30 | Buy |
| TCI Chemical | C2366 | Cyromazine >98.0%(HPLC)(T) | 66215-27-8 | 5g | $36 | 2026-04-30 | Buy |
Cyromazine Chemical Properties, Uses, Production
Description
Cyromazine is a triazine insect growth regulator that can be used as an insecticide and an acarcide. It is a kind of cyclopropylderivative of melamine, and also belongs to the family of aminotriazines which are compound consisting of an amino group attached to a triazine ring. It has specific activity against dipterous larvae, and has been approved by FDA for being applied to livestock. It is not a kind of cholinesterase inhibitor, and taking effect through affecting the nervous system of the immature larval stage of the insects.
References
https://pubchem.ncbi.nlm.nih.gov/compound/cyromazine#section=Top
https://en.wikipedia.org/wiki/Cyromazine
http://pmep.cce.cornell.edu/profiles/insect-mite/cadusafos-cyromazine/cyromazine/insect-prof-cyromazine.html
Chemical Properties
White crystalline powder. The solubility in water is 11,000 mg/L at 20°C and pH 7.5, and the hydrolysis is not obvious at pH 5-9.
Uses
Cypromazine is a high-efficiency and low-toxicity insecticide. It is mainly used to control leafminer pests, has a good control effect on Liriomyza, and can also be used to control flies.
Application
Cyromazine is an insect growth regulator, used to control fly larvae in livestock and poultry manure. It can be fed directly to livestock or applied directly to fly breeding sites. Cyromazine also exhibits systemic activity and is used as a foliar spray to control leaf miners in vegetables, potatoes, etc., and on mushrooms.
Definition
ChEBI: Cyromazine is a triamino-1,3,5-triazine. It has a role as a triazine insecticide and a mouse metabolite.
Preparation
Cyromazine is prepared by the reaction of cyanuric chloride and cyclopropylamine to obtain 2-Cyclopropylamino-4,6-dichloro-triazepine, and then reacts with ammonia to obtain 2-Cyclopropylamino-4-chloro-6-aminostriazepine, and then reacting with ammonia to produce.
General Description
N-Cyclopropyl-2,4,6-triamino-1,3,5-triazine, also known as cyromazine, is an insect growth regulator(IGR) that is commonly used as an insecticide. It undergoes metabolism in plants and animals to form melamine. Surface-enhanced Raman scattering (SERS) spectroscopic study indicates that it interacts with the surface of silver colloid through the lone pair on nitrogen.
Flammability and Explosibility
Not classified
Agricultural Uses
Insecticide (insect growth regulator): As an insect growth regulator, cyromazine is fed to caged poultry and is passed through the chicken, leaving a residue in the manure. The chemical controls the growth of the fly larvae developing in the manure. Used as a foliar spray to control leaf miners in vegetables, mushrooms, potatoes and ornamentals and to control flies on animals.
Trade name
ARMOR®; CITATION; CGA-72662®; LARVADEX®; PATRON®; TRIGARD®; VETRAZIN®
Mechanism of action
Cromazine interferes with the expression of ecdysone-responsive genes, disrupting the hormonal control of metamorphosis in immature insect stages
Synthesis
3397-62-4
765-30-0
66215-27-8
2) Add 120 mL of deionized water to the intermediate obtained in step 1), followed by the addition of 7.2 g of cyclopropylamine, and the reaction system was heated to 95 °C. Slowly add the pre-prepared potassium carbonate aqueous solution (made by dissolving 7.8 g of potassium carbonate in 28 mL of deionized water) and adjust the pH of the reaction solution to 7.5-8.5. Maintain the reaction temperature at 100 °C and continuously stir the reaction for 4 h. After the reaction was completed, add 0.2 g of activated carbon. After the reaction was completed, 0.7 g of activated carbon was added and decolorized at 95 °C for 0.5 h. The activated carbon was subsequently removed by thermal filtration to obtain a clarified reaction solution. The reaction solution was cooled to 40 °C and left to crystallize for 2 h. It was further cooled to -2 °C to promote complete crystallization. The crystallized product was separated by filtration, washed with deionized water and finally dried at 90°C for 8 hours to give 15.2 g of cyromazine. The mass yield of cyromazine in this step was 90.1% and the product was a white crystalline powder, which was analyzed by high performance liquid chromatography (HPLC) and its purity was 99.4%.
Environmental Fate
Chemical/Physical. Cyromazine will react with mineral acids (e.g., hydrochloric acid, sulfuric acid) forming water-soluble salts
Metabolic pathway
Information presented in this summary is abstracted from the data evaluation published by the Pesticide Safety Directorate (PSD, 1993). The major degradation pathway of cyromazine involves the N-dealkylation of the cyclopropyl moiety to yield melamine. Both cyromazine and melamine are quite stable to biotransformation. Deamination and the formation of N-methylcyromazine were observed as minor pathways.
Degradation
Cyromazine (1) is stable to hydrolysis at pH 5, 7 and 9 and 70 °C for up to 28 days. No degradation of cyromazine was observed when irradiated under mercury vapour lamp (>290 nm) at 25 °C for up to 168 hours.
References
[1] Patent: CN108084102, 2018, A. Location in patent: Paragraph 0033; 0034; 0037; 0041
Pesticide Type
Insecticide; Acaricide; Insect Growth Regulator; Veterinary substance
Cyromazine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TNJ Chemical Industry Co.,Ltd. | 551-65418679 15856988503;15837135945 | info@tnjchem.com | China | 1884 | 62 |
| Jinan Wald Chemical Co., Ltd. | 0531-88773586 13210588999 | 304264064@qq.com | China | 192 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
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View Latest Price from Cyromazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Cyromazine
66215-27-8
|
1KG | 98%-102%; USP | 1000 KG | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | Cyromazine
66215-27-8
|
$2.00-8.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-09-01 | Cyromazine
66215-27-8
|
1kg | 99% | 1000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd |
-
- Cyromazine
66215-27-8
- 98%-102%; USP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Cyromazine
66215-27-8
- $2.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Cyromazine
66215-27-8
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
