4-Cyano-2,6-difluorobenzoic acid
- CAS No.
- 181073-82-5
- Chemical Name:
- 4-Cyano-2,6-difluorobenzoic acid
- Synonyms
- Benzoic acid, 4-cyano-2,6-difluoro-;4-Cyano-2,6-difluorobenzoic acid 95%
- CBNumber:
- CB21264058
- Molecular Formula:
- C8H3F2NO2
- Molecular Weight:
- 183.11
- MDL Number:
- MFCD09835199
- MOL File:
- 181073-82-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 2926907090 |
4-Cyano-2,6-difluorobenzoic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC52109 | 4-Cyano-2,6-difluorobenzoic acid 97% | 181073-82-5 | 100mg | $49 | 2026-06-04 | Buy |
| Apolloscientific | PC52109 | 4-Cyano-2,6-difluorobenzoic acid 97% | 181073-82-5 | 250mg | $62 | 2026-06-04 | Buy |
| Activate Scientific | AS38515 | 4-Cyano-2,6-difluorobenzoic acid 97% | 181073-82-5 | 1g | $246 | 2026-06-04 | Buy |
| Matrix Scientific | 206094 | 4-Cyano-2,6-difluorobenzoic acid | 181073-82-5 | 100.00mg | $46 | 2026-05-18 | Buy |
| Matrix Scientific | 206094 | 4-Cyano-2,6-difluorobenzoic acid | 181073-82-5 | 250.00mg | $56 | 2026-05-18 | Buy |
4-Cyano-2,6-difluorobenzoic acid Chemical Properties, Uses, Production
Synthesis
467442-15-5
181073-82-5
Step b: Synthesis of 4-cyano-2,6-difluorobenzoic acid To a solution of 3,5-difluoro-4-formylbenzonitrile (0.2 g, 1.1 mmol) in dimethyl sulfoxide (10 mL) was added an aqueous solution of potassium dihydrogen phosphate (0.41 g, 2.9 mmol, dissolved in 0.4 mL of water) and sodium chlorite (0.216 g, 2.3 mmol, dissolved in 4 mL of water) in sequence. The reaction was carried out at room temperature with stirring for about 1 hour. After completion of the reaction, the reaction mixture was diluted with water (100 mL) and the aqueous phase was extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to give 4-cyano-2,6-difluorobenzoic acid (200 mg, 91.32% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6): δ 7.95 (d, J = 7.53 Hz, 2H).
References
[1] Patent: WO2012/160464, 2012, A1. Location in patent: Page/Page column 69
[2] Patent: US2014/155398, 2014, A1. Location in patent: Paragraph 0415
[3] Patent: WO2011/28685, 2011, A1. Location in patent: Page/Page column 77; 78
4-Cyano-2,6-difluorobenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Wuhan Arike Technology Co., Ltd. | 027- 51832457 94518350 | China | 746 | 62 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Xinyanhe Pharmatech Co.,Ltd | 0519-85252752 15366845260 | taihuaren@vip.163.com | China | 1032 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
View Latest Price from 4-Cyano-2,6-difluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 4-Cyano-2,6-difluorobenzoic acid
181073-82-5
|
5mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
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- 4-Cyano-2,6-difluorobenzoic acid
181073-82-5
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
