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3,5-Difluorobenzonitrile

3,5-Difluorobenzonitrile Structure
3,5-Difluorobenzonitrile structure
CAS No.
64248-63-1
Chemical Name:
3,5-Difluorobenzonitrile
Synonyms
3,5-Difluorobenzonit;3,5-difluoro nitrile;LABOTEST-BB LT00847812;3,5-fluorobenzonitrile;3,5-Difluorobenzonitril;,5-Difluorobenzonitrile;3,5-DIFLUOROBENZONITRILE;3,5-DIFLUOROBENZEONITRILE;Benzonitrile, 3,5-difluoro-;3,5-Difluorobenzonitrile98%
CBNumber:
CB1429037
Molecular Formula:
C7H3F2N
Molecular Weight:
139.1
MDL Number:
MFCD00010311
MOL File:
64248-63-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:35:52
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3,5-Difluorobenzonitrile Properties

Melting point 84-86 °C(lit.)
Boiling point 160 °C
Density 1.2490 (estimate)
storage temp. Sealed in dry,Room Temperature
Water Solubility Insoluble in water
form powder to crystal
color White to Almost white
BRN 2082206
InChI InChI=1S/C7H3F2N/c8-6-1-5(4-10)2-7(9)3-6/h1-3H
InChIKey CQXZSEXZQVKCHW-UHFFFAOYSA-N
SMILES C(#N)C1=CC(F)=CC(F)=C1
CAS DataBase Reference 64248-63-1(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-36/37/39-36/37
RIDADR  3276
WGK Germany  3
Hazard Note  Harmful/Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29269090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

3,5-Difluorobenzonitrile price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 290203 3,5-Difluorobenzonitrile 99% 64248-63-1 5g $28.5 2026-04-30 Buy
TCI Chemical D2081 3,5-Difluorobenzonitrile >99.0%(GC) 64248-63-1 5g $41 2026-04-30 Buy
Apolloscientific PC2684 3,5-Difluorobenzonitrile 98% 64248-63-1 25g $28 2026-06-04 Buy
Apolloscientific PC2684 3,5-Difluorobenzonitrile 98% 64248-63-1 100g $89 2026-06-04 Buy
Apolloscientific PC2684 3,5-Difluorobenzonitrile 98% 64248-63-1 500g $374 2026-06-04 Buy
Product number Packaging Price Buy
290203 5g $28.5 Buy
D2081 5g $41 Buy
PC2684 25g $28 Buy
PC2684 100g $89 Buy
PC2684 500g $374 Buy

3,5-Difluorobenzonitrile Chemical Properties, Uses, Production

Uses

3,5-Difluorobenzonitrile is an aromatic nitrile compound. Aromatic nitrile compounds have a wide range of applications, serving not only as important chemical intermediates but also as key components in certain dyes, pesticides, and pharmaceuticals. 3,5-Difluorobenzonitrile can be synthesized from arylboronic acid.

Chemical Properties

white crystals

Uses

The vibrational wavenumbers, geometry and various thermodynamic parameters were studied for 3,5-difluorobenzonitrile.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 486, 1987 DOI: 10.1021/jm00386a008

General Description

The vibrational wavenumbers, geometry and various thermodynamic parameters were studied for 3,5-difluorobenzonitrile.

Synthesis

1-Bromo-3,5-difluorobenzene

461-96-1

3,5-Difluorobenzonitrile

64248-63-1

General procedure for the synthesis of 3,5-difluorobenzonitrile from 3,5-difluorobromobenzene: iPrMgCl (2M in THF, 4.1 mL) and THF (5 mL) were added to a flask containing dry LiCl (0.35 g, 8.24 mmol) at 15 °C. After stirring for 15 min, a solution of 3,5-difluorobromobenzene (1.46 g, 8.03 mmol) in THF (1 mL) was slowly added to the reaction mixture and stirring was continued for 15 min. Subsequently, DMF (1.3 mL, 12 mmol) was added at 0 °C and the mixture was stirred for 2 hours. After completion of the reaction, aqueous NH3 (7 mL, 28-30%) and I2 (4.06 g, 16 mmol) were added to the mixture. After stirring at room temperature for 2 h, the reaction mixture was poured into saturated aqueous Na2SO3 solution and extracted with CHCl3 (3 x 30 mL). The organic layers were combined, dried with Na2SO4 and filtered. After removing the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 9:1, v/v) to afford pure 3,5-difluorobenzonitrile (0.73 g) in 71% yield. Most of the nitrile compounds involved in this study were commercially available and were identified by comparison with real samples.

References

[1] Tetrahedron, 2013, vol. 69, # 5, p. 1462 - 1469

3,5-Difluorobenzonitrile Preparation Products And Raw materials

Raw materials

1-Bromo-3,5-difluorobenzene 1,3-Difluoro-5-iodobenzene Tetrahydrofuran Isopropylmagnesium chloride Water
Lithium chloride iodine N,N-Dimethylformamide Ammonia

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Preparation Products

3',5'-Difluoropropiophenone 3,5-Difluoro-benzamidine hydrochloride 5-Amino-3-fluorobenzonitrile 3,5-Difluorobenzamide 4-Cyano-2,6-difluorobenzoic acid
3,5-Difluoro-4-formylbenzonitrile 3,5-Difluorobenzamidoxime 2-broMo-3,5-difluorobenzonitrile

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3,5-Difluorobenzonitrile Suppliers

Global Suppliers ( 367)
Supplier Tel Email Country ProdList Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 64
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 3,5-Difluorobenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,5-Difluorobenzonitrile pictures 2026-09-02 3,5-Difluorobenzonitrile
64248-63-1
 $6.00 1KG 99% Henan Fengda Chemical Co., Ltd
3,5-Difluorobenzonitrile pictures 2026-06-30 3,5-Difluorobenzonitrile
64248-63-1
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
3,5-Difluorobenzonitrile pictures 2026-03-20 3,5-Difluorobenzonitrile
64248-63-1
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd

3,5-Difluorobenzonitrile Spectrum

3,5-Difluorobenzonitrile(64248-63-1)MS3,5-Difluorobenzonitrile(64248-63-1)1HNMR3,5-Difluorobenzonitrile(64248-63-1)IR13,5-Difluorobenzonitrile(64248-63-1)IR23,5-Difluorobenzonitrile(64248-63-1)Raman

64248-63-1 (3,5-Difluorobenzonitrile) Related Search:

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5-CYANO-1,3-DIFLUOROBENZENE 3,5-DIFLUOROBENZONITRILE LABOTEST-BB LT00847812 3,5-Difluorobenzonitril Benzonitrile, 3,5-difluoro- (9CI) 3,5-Difluorobenzonitrile,99% 3,5-DIFLUOROBENZEONITRILE 3,5-Difluorobenzonitrile98% Benzonitrile, 3,5-difluoro- 3,5-Difluorobenzenecarbonitrile 3,5-Difluorobenzonit 3,5-difluoro nitrile 3,5-fluorobenzonitrile 3,5-Difluorobenzonitrile> 3,5-difluorophenyl-carbonitrile ,5-Difluorobenzonitrile 64248-63-1 C7H3NF2 Cyanides/Nitriles Nitrogen Compounds Organic Building Blocks C6 to C7 Building Blocks Pyrazines C6 to C7 Cyanides/Nitriles Nitrogen Compounds FINE Chemical & INTERMEDIATES Aromatic Nitriles Fluorobenzene Fluorobenzonitrile Series Fluorine series Fluorobenzene Series NITRILE