Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate
![Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate Structure](CAS/20210305/GIF/359595-95-2.gif)
- CAS No.
- 359595-95-2
- Chemical Name:
- Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate
- Synonyms
- Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate
- CBNumber:
- CB213312983
- Molecular Formula:
- C28H28N2O4S
- Molecular Weight:
- 488.6
- MDL Number:
- MOL File:
- 359595-95-2.mol
- TDS File:
- TDS
Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate Chemical Properties, Uses, Production
Uses
MDM2/XIAP-IN-1 (compound 14) is an orally active inhibitor of dual MDM2/XIAP. MDM2/XIAP-IN-1 has anti-cancer activity with an IC50 value of 0.3 μM, which can be used in cance rescrch[1].
in vivo
MDM2/XIAP-IN-1 Pharmacokinetic Analysis in Male SD rats Model[1]Route Dose (mg/kg) AUClast (ng·h/mL) t1/2 (h) Clobs (L·h/kg) F (%) i.v. 10 4750 0.94 2.12 / p.o. 25 0.71 / / 5.9%
References
[1] Zhongzhi Wu, et al. Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor. Med. Chem. 2021, 64, 4.
Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
359595-95-2 (Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate) Related Search:
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