Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate

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Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate Basic information
Product Name:Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate
Synonyms:Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate
CAS:359595-95-2
MF:C28H28N2O4S
MW:488.6
EINECS:
Product Categories:
Mol File:359595-95-2.mol
Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate Structure
Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate Chemical Properties
Boiling point 653.4±65.0 °C(Predicted)
density 1.273±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka9.64±0.40(Predicted)
Safety Information
MSDS Information
Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate Usage And Synthesis
UsesMDM2/XIAP-IN-1 (compound 14) is an orally active inhibitor of dual MDM2/XIAP. MDM2/XIAP-IN-1 has anti-cancer activity with an IC50 value of 0.3 μM, which can be used in cance rescrch[1].
in vivo

MDM2/XIAP-IN-1 Pharmacokinetic Analysis in Male SD rats Model[1]

RouteDose (mg/kg)AUClast (ng·h/mL)t1/2 (h)Clobs (L·h/kg)F (%)
i.v.1047500.942.12/
p.o.250.71//5.9%

References[1] Zhongzhi Wu, et al. Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor. Med. Chem. 2021, 64, 4.
Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate Preparation Products And Raw materials
Tag:Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate(359595-95-2) Related Product Information
N-(3,4-Dimethylphenyl)-3a,4,5,9b-tetrahydro-4-(3-methoxyphenyl)-3H-cyclopenta[c]quinoline-8-sulfonamide Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate rel-4-[[[(3aR,4S,9bS)-3a,4,5,9b-Tetrahydro-4-(4-nitrophenyl)-3H-cyclopenta[c]quinolin-8-yl]sulfonyl]amino]benzoic acid MX-69 N-(3,4-Dimethylphenyl)-2,3,3a,4,5,9b-hexahydro-4-[4-(2-methyl-1-oxopropyl)phenyl]furo[3,2-c]quinoline-8-sulfonamide N-(3,4-Dimethylphenyl)-3a,4,5,9b-tetrahydro-4-(2-methoxyphenyl)-3H-cyclopenta[c]quinoline-8-sulfonamide