ChemicalBook >> CAS DataBase List >>Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate

Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate

Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate structure

CAS No.: 1402931-66-1

Chemical Name:: Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate

Synonyms: Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate

CBNumber:: CB213460655

Molecular Formula:: C28H29NO7

Molecular Weight:: 491.53

MDL Number:

MOL File:: 1402931-66-1.mol

Last updated:2025-04-18 09:51:48

Request For Quotation

Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate Properties

Boiling point	640.7±55.0 °C(Predicted)
Density	1.362±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka	11.79±0.70(Predicted)

Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate Chemical Properties, Uses, Production

Uses

eIF4A3-IN-15 (compound 52) is a silvestrol (HY-13251) analogue. eIF4A3-IN-15 interferes the assembling of eIF4F translation complex with EC50s of 11, 700 and 120 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-15 can be used for the research of human cancer pathogenesis[1].

References

[1] Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. DOI:10.1021/jm3011542

Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

1402931-66-1 (Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate) Related Search:

(S)-(-)-2-Azetidinecarboxylic acid ISRIB eIF4A3-IN-2 (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester A-92

2BAct(eIF2B activator 2BAct)

1of2

Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate 1402931-66-1