BI-2493 manufacturers
- BI-2493
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- $538.00
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2026-07-27
- CAS:2937344-16-4
- Purity: 99.51%
- Supply Ability: 10g
- BI-2493
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2026-06-30
- CAS:2937344-16-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- BI-2493
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2025-03-16
- CAS:2937344-16-4
- Min. Order: 5mg
- Purity: 98%+ HPLC HNMR
- Supply Ability: 10g
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| | BI-2493 Basic information |
| Product Name: | BI-2493 | | Synonyms: | Spiro[1,2-benzisoxazole-7(4H),4′(5′H)-benzo[b]thiophene]-3′-carbonitrile, 2′-amino-5,6,6′,7′-tetrahydro-3-[2-[(2S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-, (4′S)-;bi-2493;(S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile;(S)-2-Amino-3'-[2-[(S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile;(S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile | | CAS: | 2937344-16-4 | | MF: | C24H27N7OS | | MW: | 461.58 | | EINECS: | | | Product Categories: | | | Mol File: | 2937344-16-4.mol |  |
| | BI-2493 Chemical Properties |
| Boiling point | 774.2±70.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | | pka | 8.62±0.40(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | BI-2493 Usage And Synthesis |
| Uses | BI-2493 is a structural analog of BI-2865 and a highly selective pan-KRAS inhibitor. This compound can attenuate tumor growth and can also be used for cancer disease research. | | in vivo | BI-2493 (90 mg/kg, p.o., twice daily for 21 days) exhibits tumor-suppressive activity in LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models[1]. | Animal Model: | LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models | | Dosage: | 90 mg/kg | | Administration: | Oral gavage (p.o.), twice daily for 21 days | | Result: | Reduced tumor growth in mice carrying KRAS G12C, G12D, G12V, and A146V mutation models, without causing significant toxicity to the mice. |
| | IC 50 | K-Ras WT |
| | BI-2493 Preparation Products And Raw materials |
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