ChemicalBook >> CAS DataBase List >>5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide

5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide

5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide structure

CAS No.: 2932264-95-2

Chemical Name:: 5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide

Synonyms: 5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide;1H-Indazole-3-carboxamide, 5-[[4-[4-[(dimethylamino)methyl]-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-N,1-dimethyl-

CBNumber:: CB213818324

Molecular Formula:: C21H25N9O

Molecular Weight:: 419.48

MDL Number:

MOL File:: 2932264-95-2.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:51

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5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide Properties

Density	1.354±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	12.925±0.46(predicted)
form	Solid
color	White to off-white

5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0133439	Syk-IN-4 98.0%	2932264-95-2	5mg	$487	2026-06-04	Buy
ChemScene	CS-0133439	Syk-IN-4 98.0%	2932264-95-2	10mg	$867	2026-06-04	Buy
ChemScene	CS-0133439	Syk-IN-4 98.0%	2932264-95-2	25mg	$1733	2026-06-04	Buy
ChemScene	CS-0133439	Syk-IN-4 98.0%	2932264-95-2	50mg	$2817	2026-06-04	Buy
ChemScene	CS-0133439	Syk-IN-4 98.0%	2932264-95-2	100mg	$4225	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0133439	5mg	$487	Buy
CS-0133439	10mg	$867	Buy
CS-0133439	25mg	$1733	Buy
CS-0133439	50mg	$2817	Buy
CS-0133439	100mg	$4225	Buy

5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide Chemical Properties, Uses, Production

Uses

Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers[1].

in vivo

Syk-IN-4 exhibits moderate oral bioavailability (60%) following oral administration (1 mg/kg) in male Hans Wistar rats^[1].
Syk-IN-4 exhibits high plasma clearance (151 mL/min/kg) combined with large volumes of distribution (1.0 L/kg respectively) following i.v. administration (0.5 mg/kg) in male Hans Wistar rats^[1].

References

[1] Neil P Grimster, et al. Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors. Bioorg Med Chem Lett. 2020 Jul 24;127433. DOI:10.1016/j.bmcl.2020.127433

5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60

Supplier	Advantage
Shanghai YuanYe Biotechnology Co., Ltd.	60

2932264-95-2 (5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide) Related Search:

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5-[[4-[4-[(Dimethylamino)methyl]-3-methyl-1-pyrazolyl]-2-pyrimidinyl]amino]-N,1-dimethyl-1H-indazole-3-carboxamide 1H-Indazole-3-carboxamide, 5-[[4-[4-[(dimethylamino)methyl]-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-N,1-dimethyl- 2932264-95-2