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ChemicalBook >> CAS DataBase List >>7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Structure
7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- structure
CAS No.
2254693-15-5
Chemical Name:
7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-
Synonyms
SRX3207;SRX-3207,SRX3207;7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-
CBNumber:
CB28095086
Molecular Formula:
C29H29N7O3S
Molecular Weight:
555.65
MDL Number:
MFCD33402171
MOL File:
2254693-15-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 08:17:50
Request For Quotation

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Properties

storage temp. Store at -20°C
solubility DMSO : 5 mg/mL (9.00 mM; Need ultrasonic)
form Solid
color Light yellow to light brown

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth EQD69315 SRX3207 2254693-15-5 10mg $931.5 2026-06-04 Buy
Biosynth EQD69315 SRX3207 2254693-15-5 25mg $1518.75 2026-06-04 Buy
Biosynth EQD69315 SRX3207 2254693-15-5 50mg $2429.5 2026-06-04 Buy
ChemScene CS-0120685 SRX3207 98.36% 2254693-15-5 5mg $394 2026-06-04 Buy
ChemScene CS-0120685 SRX3207 98.36% 2254693-15-5 10mg $548 2026-06-04 Buy
Product number Packaging Price Buy
EQD69315 10mg $931.5 Buy
EQD69315 25mg $1518.75 Buy
EQD69315 50mg $2429.5 Buy
CS-0120685 5mg $394 Buy
CS-0120685 10mg $548 Buy

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Chemical Properties, Uses, Production

Uses

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression[1][2].

Biological Activity

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression[1][2]. SRX3207 (10 μmol/L) is able to block p-AKT at concentration[1].SRX3207 has sufficient solubility in water (43 μmol/L)[1]. SRX3207 (10 mg/kg, orally) increases antitumor immune response[1].

in vivo

SRX3207 (10 mg/kg, orally) increases antitumor immune response[1].

Animal Model:LLC or B16 or B16-OVA or CT26 (1 × 105) cells were injected subcutaneously into syngeneic mice[1].
Dosage:10 mg/kg.
Administration:Orally, starting from day 10 when tumors reached 100 mm3 until tumors were harvested on day 21.
Result:Blocked phosphorylation of Syk at 348 site and Y525/526 site.
Blocked immunosuppressive MΦ polarization.
Blocked tumor growth and increased survival effectively.

IC 50

Syk: 10.7 nM (IC50); PI3Kα: 861 nM (IC50); PI3Kδ: 1280 nM (IC50); PI3Kγ: 11100 nM (IC50); Zap70: 1300 nM (IC50)

References

[1]. Shweta Joshi, et al. Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression. Molecular Cancer Therapeutics. 2020. [2]. Shweta Joshi, et al. Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression. Mol Cancer Ther. 2020 Mar;19(3):755-764.

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Suppliers

Global Suppliers ( 33)
Supplier Tel Email Country ProdList Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4565 58
Nantong Hi-Future Biotechnology Co., Ltd +86-0513; 18051384581 sales@chemhifuture.com China 3075 58
InvivoChem 13549236410 sales@invivochem.cn China 6745 58
Changzhou Borl Biotechnology Co.,LTD 13656121842 luyan0021@163.com China 265 58
Supplier Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58
TargetMol Chemicals Inc. 58
InvivoChem 58
ShangHai ChuanQian Chemcial Technique Centre 58
Nantong Hi-Future Biotechnology Co., Ltd 58
InvivoChem 58
Changzhou Borl Biotechnology Co.,LTD 58

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SRX3207 pictures 2026-09-10 SRX3207
2254693-15-5
 $51.00-195.00 99.85% 10g TargetMol Chemicals Inc.
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  • SRX3207
    2254693-15-5
  • $51.00-195.00
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7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- Spectrum

7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-(2254693-15-5)1HNMR

2254693-15-5 (7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-) Related Search:

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7H-Thieno[3,2-b]pyran-7-one, 3-[4-[[4-[4-(1-azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)- SRX3207 SRX-3207,SRX3207 2254693-15-5 C29H29N7O3S