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PHYLLANTHIN

PHYLLANTHIN structure

CAS No.: 10351-88-9

Chemical Name:: PHYLLANTHIN

Synonyms: NSC 619043;PHYLLANTHIN;Phyllanthin-RM;Subfoliar Pearlin;Phyllanthin (15 mg);PHOSPHO-L-SERINE, O-(RG);Phyllanthin, 10 mM in DMSO;3,3',4,4',9,9'-HexaMethoxylignan;Tetra-O-Methylsecoisolariciresinol;(2S,3S)-(+)-1,4-Dimethoxy-2,3-diveratrylbutane

CBNumber:: CB2143758

Molecular Formula:: C24H34O6

Molecular Weight:: 418.52

MDL Number:: MFCD17166965

MOL File:: 10351-88-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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PHYLLANTHIN Properties

Melting point	96℃
Boiling point	530.6±50.0 °C(Predicted)
Density	1.069
storage temp.	15-25°C
solubility	DMF: 15 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form	Solid
color	White to off-white
BRN	2066503
Major Application	pharmaceutical (small molecule)
InChI	1S/C24H34O6/c1-25-15-19(11-17-7-9-21(27-3)23(13-17)29-5)20(16-26-2)12-18-8-10-22(28-4)24(14-18)30-6/h7-10,13-14,19-20H,11-12,15-16H2,1-6H3/t19-,20-/m1/s1
InChIKey	KFLQGJQSLUYUBF-WOJBJXKFSA-N
SMILES	COC[C@@H](Cc1ccc(OC)c(OC)c1)[C@@H](COC)Cc2ccc(OC)c(OC)c2
LogP	4.110 (est)
FDA UNII	75O1TFF47Z
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

WGK Germany	3
HS Code	3824999270
Storage Class	11 - Combustible Solids

PHYLLANTHIN price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHL89756	Phyllanthin phyproof? Reference Substance	10351-88-9	10MG	$562	2026-04-30	Buy
Sigma-Aldrich	1536509	Phyllanthin United States Pharmacopeia (USP) Reference Standard	10351-88-9	15mg	$368	2026-04-30	Buy
Sigma-Aldrich	75110	Phyllanthin analytical standard	10351-88-9	10mg	$408	2022-05-15	Buy
Cayman Chemical	11745	Phyllanthin ≥98%	10351-88-9	500μg	$36	2026-04-30	Buy
Cayman Chemical	11745	Phyllanthin ≥98%	10351-88-9	1mg	$55	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHL89756	10MG	$562	Buy
1536509	15mg	$368	Buy
75110	10mg	$408	Buy
11745	500μg	$36	Buy
11745	1mg	$55	Buy

PHYLLANTHIN Chemical Properties,Uses,Production

Uses

Phyllanthin is a chemical extract from the Phyllanthus niruri plant and displays pharmacological effects as an anti-diabetic action, anti-arthritic, and inhibitor of P-gp.

Definition

ChEBI: Phyllanthin is a lignan.

in vivo

Phyllanthin (10 mg/kg; oral administration; once a day; 30 days) has protective effects in carbon tetrachloride (HY-Y0298) induced hepatotoxicity and experimental liver fibrosis in mice ^[2].
Phyllanthin (30 mg/kg; oral administration; single dose) exerts anti-tumor effects in diethylnitrosamine (HY-N7434) induced liver carcinogenesis in rats ^[5].
Phyllanthin (20-100 mg/kg; oral administration; once a day; 14 days) inhibits cellular and humoral immune responses in Balb/C mice ^[6].

Animal Model:	Carbon tetrachloride (HY-Y0298) treated Swiss strain female mice (32-35 g) ^[2]
Dosage:	10 mg/kg
Administration:	Oral administration (p.o.); once a day; 30 days
Result:	Normalized the level of liver marker enzymes (ALT and AST) and collagen content in hepatotoxicity and experimental liver fibrosis mice. Restored normal liver architecture, reversed the formation of continuous fibrotic septa between the central and portal veins and nodules. Reduced the levels of TGF-β1, ALK5, p-Smad2 and p-Smad3 in hepatotoxicity and experimental liver fibrosis mice.

Animal Model:	Diethylnitrosamine (Cat. No. HY-N7434) treated male Wistar albino rats (210-230 g)^[5]
Dosage:	30 mg/kg
Administration:	Oral administration (p.o.); single dose
Result:	Significantly reduced 8-OHdG levels and delayed the oxidative damage in diethylnitrosamine -induced liver cancer rats. Significantly reduced liver tissue injury biomarkers (ALT, AST, GGT, ALP and LDH) levels and tumor markers (AFP and CEA). Reduced cellular enlargement, nodules, and hyperplasiaenlargement in diethylnitrosamine-induced liver tissue.

Animal Model:	Male Balb/C mice aged 6-8 weeks old (18-22 g) ^[6]
Dosage:	20 mg/kg, 40 mg/kg, and 100 mg/kg
Administration:	Oral administration (p.o.); once a day; 14 days
Result:	Dose-dependently inhibited CD11b/CD18 adhesion, the engulfment of E.coli by peritoneal macrophages molecules, NO and MPO release. Dose-dependently inhibited T and B lymphocytes proliferation and down-regulated Th1 (IL-2 and IFN-γ) and Th2 (IL-4) cytokines. Dose-dependently inhibited the sheep red blood cell (sRBC)-induced swelling rate of mice paw in delayed type hypersensitivity. Significantly inhibited the serum levels of ceruloplasmin and lysozyme at higher doses (40 and 100 mg/kg). Dose-dependently down-regulated anti-sRBC immunoglobulins (IgM and IgG) antibody titer.

PHYLLANTHIN Preparation Products And Raw materials

Raw materials

Preparation Products

PHYLLANTHIN Suppliers

Global( 108)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	China	2376	60
Shanghai Tauto Biotech Co., Ltd.	021-51320588	tauto@tautobiotech.com	China	3984	66
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58
Shanghai Yongye Biotechnology Co., Ltd.	86-021-61559134 15921386130	3423497944@qq.com	China	8135	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
ALB Technology Limited	702-983-3769	sales@albtechnology.com	United States	2992	55
Wuhan ChemFaces Biochemical Co., Ltd.	18607101326 15172504745	aileen@chemfaces.com	China	6904	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
BioBioPha Co., Ltd.	65
Chengdu Biopurify Phytochemicals Ltd.	60
Shanghai Tauto Biotech Co., Ltd.	66
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Shanghai Yongye Biotechnology Co., Ltd.	55
Sigma-Aldrich	80
ALB Technology Limited	55
Wuhan ChemFaces Biochemical Co., Ltd.	55

View Lastest Price from PHYLLANTHIN manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	Phyllanthin 10351-88-9	$48.00-179.00		99.95%	10g	TargetMol Chemicals Inc.

Phyllanthin
10351-88-9
$48.00-179.00
99.95%
TargetMol Chemicals Inc.

PHYLLANTHIN Spectrum

PHYLLANTHIN(10351-88-9)¹HNMR

10351-88-9(PHYLLANTHIN)Related Search:

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HYPOPHYLLANTHIN 28-deMethyl -β-aMyrone 4'-Demethylpodophyllotoxin (-)-Syringaresinol-4-O-beta-D-glucopyranoside EUDESMINE

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PHYLLANTHIN PHOSPHO-L-SERINE, O-(RG) 1,1'-[(2S,3S)-2,3-Bis(methoxymethyl)-1,4-butanediyl]bis[3,4-dimethoxybenzene] NSC 619043 Phyllanthin (15 mg) 3,3',4,4',9,9'-HexaMethoxylignan Tetra-O-Methylsecoisolariciresinol (2S,3S)-(+)-1,4-Dimethoxy-2,3-diveratrylbutane Subfoliar Pearlin Benzene,1,1'-[(2S,3S)-2,3-bis(methoxymethyl)-1,4-butanediyl]bis[3,4-dimethoxy- hepatoprotective,inhibit,bioactive,antioxidative,Phyllanthin,Phyllanthus,Inhibitor,amarus,lignan Phyllanthin-RM Phyllanthin, 10 mM in DMSO 10351-88-9