1-isopropylpiperidin-4-ol
- CAS No.
- 5570-78-5
- Chemical Name:
- 1-isopropylpiperidin-4-ol
- Synonyms
- 1-isopropylpiperidin-4-ol;1-propan-2-yl-4-piperidinol;4-Hydroxy-1-isopropylpiperidine;1-(1-Methylethyl)piperidin-4-ol;N-isopropyl-4-hydroxypiperidine;1-(1-Methylethyl)-4-piperidinol;4-Piperidinol,1-(1-Methylethyl)-;1-isopropylpiperidin-4-ol(SALTDATA: FREE)
- CBNumber:
- CB2901527
- Molecular Formula:
- C8H17NO
- Molecular Weight:
- 143.23
- MDL Number:
- MFCD00101977
- MOL File:
- 5570-78-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HS Code | 2933399990 |
1-isopropylpiperidin-4-ol price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B451578 | 1-Isopropylpiperidin-4-ol | 5570-78-5 | 500mg | $130 | 2021-12-16 | Buy |
| TRC | B451578 | 1-Isopropylpiperidin-4-ol | 5570-78-5 | 100mg | $60 | 2021-12-16 | Buy |
| Apolloscientific | OR909302 | 1-isopropylpiperidin-4-ol 95% | 5570-78-5 | 1g | $515 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0135436 | 1-ISOPROPYLPIPERIDIN-4-OL 95.00% | 5570-78-5 | 1G | $867.12 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0135436 | 1-ISOPROPYLPIPERIDIN-4-OL 95.00% | 5570-78-5 | 5G | $1722.11 | 2021-12-16 | Buy |
1-isopropylpiperidin-4-ol Chemical Properties,Uses,Production
Synthesis
5382-16-1
67-64-1
5570-78-5
The general procedure for the synthesis of 1-isopropyl-4-piperidinol from 4-hydroxypiperidine and acetone was as follows: a mixture of 4-hydroxypiperidine (10 g, 0.10 mol), acetone (21.8 mL, 0.30 mol), acetic acid (5.7 mL, 0.10 mol), and tetrahydrofuran (150 mL) was stirred in an ice bath for 15 minutes. Subsequently, sodium triacetoxyborohydride (31.3 g, 0.15 mol) was added in batches and stirring was continued for 10 minutes. The reaction mixture was gradually warmed up to room temperature, stirred for 10 minutes and then stirred at 40°C for 2.5 hours. After the reaction was completed, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in water (50 mL). The pH of the aqueous solution was adjusted to 9 with concentrated ammonia (0.88) and stirred continuously for 30 minutes. Next, the reaction mixture was extracted with ether (2 x 200 mL), the organic phases were combined, dried with anhydrous sodium sulfate and concentrated in vacuum to obtain a yellow oil. The oily substance was purified by silica gel column chromatography with the eluent ratio of dichloromethane: methanol: concentrated ammonia (0.88), which was tapered from 96:4:1 to 90:10:1, to give the title compound 1-isopropyl-4-piperidinol as a yellow oily substance in a yield quantified as 14.6 g. The product was purified by 1H-NMR (CDCl3, 400 MHz) and mass spectrometry (MS ES+ m/ z 144 [MH]+) to confirm the structure.
References
[1] Patent: EP1595881, 2005, A1. Location in patent: Page/Page column 64
[2] Patent: WO2007/52124, 2007, A1. Location in patent: Page/Page column 17
[3] Patent: WO2009/121812, 2009, A1. Location in patent: Page/Page column 69
[4] Patent: US2009/233910, 2009, A1. Location in patent: Page/Page column 57
1-isopropylpiperidin-4-ol Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49977 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43339 | 58 |
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