1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
- CAS No.
- 487-49-0
- Chemical Name:
- 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
- Synonyms
- Ononetin;2,4-Dihydroxyphenyl 4-Methoxybenzyl Ketone;4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;Ethanone,1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)-;2’, 4’-Dihydroxy-2(4-methoxyphenyl) acetophenone (Ononetin);Inhibitor,Transient receptor potential channels,Ononetin,inhibit,Ca2+,TRP Channel,TRPM3,deoxybenzoin
- CBNumber:
- CB21458187
- Molecular Formula:
- C15H14O4
- Molecular Weight:
- 258.27
- MDL Number:
- MFCD00020119
- MOL File:
- 487-49-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone >98.0%(T) | D4816 | 1g | $276 |
| 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone >98.0%(T) | D4816 | 200mg | $80 |
| Ononetin ≥98% | 35813 | 25mg | $43 |
| Ononetin ≥98% | 35813 | 50mg | $82 |
| Ononetin ≥98% | 35813 | 100mg | $152 |
| Melting point | 158.0 to 162.0 °C |
|---|---|
| Boiling point | 464.7±14.0 °C(Predicted) |
| Density | 1.275±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 7.65±0.35(Predicted) |
| color | White to Light yellow to Dark green |
| FDA UNII | 4S084Z7YS4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H400 |
| Precautionary statements | P273-P391-P501 |
| RTECS | KM5775350 |
| HS Code | 2914.50.3000 |
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4816 | 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone >98.0%(T) | 487-49-0 | 1g | $276 | 2025-07-31 | Buy |
| TCI Chemical | D4816 | 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone >98.0%(T) | 487-49-0 | 200mg | $80 | 2025-07-31 | Buy |
| Cayman Chemical | 35813 | Ononetin ≥98% | 487-49-0 | 25mg | $43 | 2026-04-30 | Buy |
| Cayman Chemical | 35813 | Ononetin ≥98% | 487-49-0 | 50mg | $82 | 2026-04-30 | Buy |
| Cayman Chemical | 35813 | Ononetin ≥98% | 487-49-0 | 100mg | $152 | 2026-04-30 | Buy |
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Chemical Properties,Uses,Production
Uses
Ononetin is a potent and selective transient receptor potential TRMP3 blocker and may represent a novel concept for analgesic treatment.
Definition
ChEBI: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone is a stilbenoid.
Preparation
Preparation by condensation of p-methoxyphenyl-acetonitrile with resorcinol (Hoesch reaction).
in vivo
Ononetin (10 mg/kg, i.p.) treatment completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms and suggests that TRPM3 may be a tractable target for inflammatory pain[2].
IC 50
TRPM3: 0.3 μM (IC50)
storage
Store at +4°C
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24529 | 81 |
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