1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone

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1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone manufacturers

  • Ononetin
  • Ononetin pictures
  • $47.00
  • 2026-08-08
  • CAS:487-49-0
  • Purity: 98.06%
  • Supply Ability: 10g
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Basic information
Product Name:1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
Synonyms:Ethanone,1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)-;2,4-Dihydroxyphenyl 4-Methoxybenzyl Ketone;2’, 4’-Dihydroxy-2(4-methoxyphenyl) acetophenone (Ononetin);4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;Inhibitor,Transient receptor potential channels,Ononetin,inhibit,Ca2+,TRP Channel,TRPM3,deoxybenzoin;2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;Ononetin
CAS:487-49-0
MF:C15H14O4
MW:258.27
EINECS:
Product Categories:
Mol File:487-49-0.mol
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Structure
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Chemical Properties
Melting point 158.0 to 162.0 °C
Boiling point 464.7±14.0 °C(Predicted)
density 1.275±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility soluble in Methanol
form powder to crystal
pka7.65±0.35(Predicted)
color White to Light yellow to Dark green
Safety Information
RTECS KM5775350
HS Code 2914.50.3000
MSDS Information
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Usage And Synthesis
UsesOnonetin is a potent and selective transient receptor potential TRMP3 blocker and may represent a novel concept for analgesic treatment.
DefinitionChEBI: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone is a stilbenoid.
PreparationPreparation by condensation of p-methoxyphenyl-acetonitrile with resorcinol (Hoesch reaction).
in vivo

Ononetin (10 mg/kg, i.p.) treatment completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms and suggests that TRPM3 may be a tractable target for inflammatory pain[2].

IC 50TRPM3: 0.3 μM (IC50)
storageStore at +4°C
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Preparation Products And Raw materials
Preparation Products7-Hydroxy-3-(4-methoxyphenyl)-2-methyl-4H-chromen-4-one-->1-(2-Hydroxy-4-methoxyphenyl)-2-(4-methoxyphenyl)ethanone
Tag:1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone(487-49-0) Related Product Information
1-(2,4,6-Trihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Biochanin A-beta-D-glucoside 4',7-Dimethoxyisoflavone Ononin 4',6,7-Trimethoxyisoflavone Rotenone Formononetin 4',7-Dimethoxy-5-hydroxyisoflavone 5,7-Dihydrox -4'-methoxyisoflavone 2-Carbethoxy-5,7-dihydroxy-4'-methoxyisoflavone 6,7-Dihydroxy-4'-methoxyisoflavone PSEUDOBAPTIGENIN 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone 4H-1-Benzopyran-4-one, 3-(3,4-dimethoxyphenyl)-7-methoxy- 7,8-Dihydroxy-4'-methoxyisoflavone ICHTHYNONE AKOS 212-61 iso-Osajin-4'-methyl ether