Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N,N'-Octamethylenebis(dichloroacetamide)

N,N'-Octamethylenebis(dichloroacetamide)

N,N'-Octamethylenebis(dichloroacetamide) Structure
N,N'-Octamethylenebis(dichloroacetamide) structure
CAS No.
1477-57-2
Chemical Name:
N,N'-Octamethylenebis(dichloroacetamide)
Synonyms
SKL878;r-010-tk;win18441;win18446;win18,446;NSC 59354;bisdiamine;FERTILYSIN;bis-diamine;Fertilysine
CBNumber:
CB2146249
Molecular Formula:
C12H20Cl4N2O2
Molecular Weight:
366.11
MDL Number:
MFCD00000841
MOL File:
1477-57-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:50:16
Request For Quotation

N,N'-Octamethylenebis(dichloroacetamide) Properties

Melting point 118-120 °C
Boiling point 530℃
Density 0.726
refractive index 1.6200 (estimate)
Flash point 275℃
storage temp. Inert atmosphere,2-8°C
solubility Acetone (Very Slightly), DMSO (Slightly), Methanol (Sparingly, Heated, Sonicated
form Solid
pka 12.28±0.46(Predicted)
color White to Off-White
InChI 1S/C12H20Cl4N2O2/c13-9(14)11(19)17-7-5-3-1-2-4-6-8-18-12(20)10(15)16/h9-10H,1-8H2,(H,17,19)(H,18,20)
InChIKey FAOMZVDZARKPFJ-UHFFFAOYSA-N
SMILES O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl
CAS DataBase Reference 1477-57-2
FDA UNII 3F56RA64JN
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Warning
Hazard statements  H312+H332-H351
Precautionary statements  P202-P261-P280-P302+P352+P312-P304+P340+P312-P308+P313
Hazard Codes  Xn
Risk Statements  20/21/22-40
Safety Statements  24/25-45-36
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Carc. 2
Toxicity LD50 orally in mice: >16000 mg/kg (Coulston)
NFPA 704
1
2 0

N,N'-Octamethylenebis(dichloroacetamide) price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3187 WIN 18446 ≥98% (HPLC) 1477-57-2 50MG $136 2026-04-30 Buy
Cayman Chemical 14018 WIN 18,446 ≥98% 1477-57-2 50mg $64 2026-04-30 Buy
Cayman Chemical 14018 WIN 18,446 ≥98% 1477-57-2 100mg $96 2026-04-30 Buy
Cayman Chemical 14018 WIN 18,446 ≥98% 1477-57-2 250mg $145 2026-04-30 Buy
Usbiological 257104 WIN 18446 Asreported 1477-57-2 50mg $366 2026-06-03 Buy
Product number Packaging Price Buy
SML3187 50MG $136 Buy
14018 50mg $64 Buy
14018 100mg $96 Buy
14018 250mg $145 Buy
257104 50mg $366 Buy

N,N'-Octamethylenebis(dichloroacetamide) Chemical Properties, Uses, Production

Chemical Properties

white crystalline powder

Uses

Win 18446 was shown to inhibit the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis and in the embryonic murine gonad.

Definition

ChEBI: A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neon tal and adult murine testis. It down-regulates sex related genes in zebrafish.

Biological Activity

win 18446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2 (aldh1a2), with ic50 value of 300 nm [1].aldh1a2, expressed almost exclusively in the testes, localizes to developing germ cells within the seminiferous tubules and strongly binds retinol, but does not recognize acetaldehyde as a substrate, suggesting that aldh1a2 functions in testicular retinoic acid biosynthesis [1].in whole testes or germ cells isolated from mice at 2 days postpartum, win 18,446 alone (1 μm) or in combination with retinol significantly reduced the expression of stra8, a marker for retinoic acid activity [2].in male rabbits, oral administration of win 18446 at 200 mg/kg for 16 weeks substantially reduced intratesticular concentrations of retinoic acid, significantly impaired spermatogenesis, and resulted in infertility. reduced concentrations of intratesticular retinoic acid became obvious after only 4 weeks of treatment and preceded the decrease in sperm counts and the loss of mature germ cells in tissue samples. sperm counts and fertility recovered after treatment was discontinued [1].[1]. amory j k, muller c h, shimshoni j a, et al. suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. journal of andrology, 2011, 32(1): 111-119.[2]. hogarth c a, evanoff r, snyder e, et al. suppression of stra8 expression in the mouse gonad by win 18,446. biology of reproduction, 2011, 84(5): 957-965.

Safety Profile

Poison by intraperitoneal route.Human systemic effects by ingestion: nausea andvomiting. Human reproductive effects by ingestion:changes in spermatogenesis. An experimental teratogen.Other experimental reproductive effects. Human mutationdata reporte

storage

Store at +4°C

N,N'-Octamethylenebis(dichloroacetamide) Preparation Products And Raw materials

Raw materials

Preparation Products

N,N'-Octamethylenebis(dichloroacetamide) Suppliers

Global Suppliers ( 110)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9331 58
Tianjin Anhao Biological Technology Co., Ltd. sales@ahpharmatech.com China 5734 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Nanjing Vital Chemical Co., Ltd. 65
Bide Pharmatech Ltd. 60
Finetech Industry Limited 58
Tianjin Anhao Biological Technology Co., Ltd. 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
EMMX Biotechnology LLC 60
BOC Sciences 65

View Latest Price from N,N'-Octamethylenebis(dichloroacetamide) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WIN 18446 pictures 2026-07-15 WIN 18446
1477-57-2
 $34.00-73.00 99.69% 10g TargetMol Chemicals Inc.
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) pictures 2025-12-24 N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
1477-57-2
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
  • WIN 18446 pictures
  • WIN 18446
    1477-57-2
  • $34.00-73.00
  • 99.69%
  • TargetMol Chemicals Inc.

N,N'-Octamethylenebis(dichloroacetamide) Spectrum

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)(1477-57-2)1HNMRN,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)(1477-57-2)IR1N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)(1477-57-2)IR2

1477-57-2 (N,N'-Octamethylenebis(dichloroacetamide)) Related Search:

Hexylamine Allylamine hydrochloride N-Ethylacetamide 2-Chloro-N-methylacetamide N-Methylacetamide
N-Methylethylamine hydrochloride Diethylamine N-Ethylmethylamine n-Propylamine hydrochloride N,N'-Octamethylenebis(dichloroacetamide)
Ethylbutylamine N-Methylbutylamine N-Methylhexylamine Butylamine hydrochloride n-Hexylamine hydrochloride
Octylamine hydrochloride N,N'-Dimethyl-1,8-octanediamine Dichloroacetaldehyde hydrate

1of4

FERTILYSIN N,N'-BIS(DICHLOROACETYL)-1,8-OCTAMETHYLENEDIAMINE N,N'-OCTA-METHYLENE-BIS[2,2-DICHLOROACETAMIDE] bisdiamine bis-diamine n,n’,1,8-octanediylbis(2,2-dichloro-acetamid n,n’-bis(dichloroacetyl)-1,8-diaminooctane n,n’-bis(dichloroacetyl)-1,8-octanediamine n,n’-octamethylenebis(2,2-dichloro-acetamid n,n’-octamethylenebis(2,2-dichloroactamide) n,n-bis(dichloroacetyl)-1,8-octanediamine r-010-tk win18,446 win18441 win18446 NSC 59354 N,N''-OCTMETHYLENEBIS (DICHLOROACETAMIDE) N,N'-(1,8-Octanediyl)bis(2,2-dichloroacetamide) N,N'-Octamethylenebis(dichloroacetamide),97% AcetaMide,N,N'-1,8-octanediylbis[2,2-dichloro- Fertilysine SKL878 WIN 18446,Stra8,testis,spermatogenesis,inhibit,Win18446,Aldehyde Dehydrogenase (ALDH),Testes,Win-18446,Inhibitor 2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetamide) WIN 18446, 10 mM in DMSO N. N '- Octamethylene Dichloroacetamide N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetamide) N,N'-Octamethylenebis(dichloroacetamide) 1477-57-2 C12H20Cl4N2O2