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2-Chloro-N-methylacetamide

2-Chloro-N-methylacetamide Structure
2-Chloro-N-methylacetamide structure
CAS No.
96-30-0
Chemical Name:
2-Chloro-N-methylacetamide
Synonyms
N-Methylchloroacetamide;chloroacetylmethylamide;N-METHYL-2-CHLOROACETAMIDE;96-30-0;usafdo-35;USAF do-35;WLN: G1VM1;OTAVA-BB BB7020410071;2-chloro-n-methyl-acetamid;2-CHLORO-N-METHYLACETAMIDE
CBNumber:
CB0341389
Molecular Formula:
C3H6ClNO
Molecular Weight:
107.54
MDL Number:
MFCD00018913
MOL File:
96-30-0.mol
MSDS File:
SDS
Last updated:2026-05-27 17:38:22
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2-Chloro-N-methylacetamide Properties

Melting point 38-40°C
Boiling point 112-115°C 20mm
Density 1.127±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 14.38±0.46(Predicted)
color White to Off-White
InChI InChI=1S/C3H6ClNO/c1-5-3(6)2-4/h2H2,1H3,(H,5,6)
InChIKey HOZLOOPIXHWKCI-UHFFFAOYSA-N
SMILES C(NC)(=O)CCl
CAS DataBase Reference 96-30-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 2WW385P414
NIST Chemistry Reference ClCON(CH3)2(96-30-0)
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P310-P302+P352-P305+P351+P338
target organs Respiratory system
Risk Statements  36/37/38-43-22
Safety Statements  26-36/37/39-36/37-24
WGK Germany  WGK 3
RTECS  AB5775000
HazardClass  IRRITANT
HS Code  29241990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
3 0

2-Chloro-N-methylacetamide price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich OTV000964 2-Chloro-N-methylacetamide 96-30-0 1g $77.9 2026-04-30 Buy
TCI Chemical C3014 2-Chloro-N-methylacetamide >98.0%(GC) 96-30-0 5g $66 2026-04-30 Buy
TCI Chemical C3014 2-Chloro-N-methylacetamide >98.0%(GC) 96-30-0 25g $221 2026-04-30 Buy
Usbiological 417126 2-Chloro-N-methylacetamide 96-30-0 1g $312 2026-06-03 Buy
Usbiological 417126 2-Chloro-N-methylacetamide 96-30-0 5g $396 2026-06-03 Buy
Product number Packaging Price Buy
OTV000964 1g $77.9 Buy
C3014 5g $66 Buy
C3014 25g $221 Buy
417126 1g $312 Buy
417126 5g $396 Buy

2-Chloro-N-methylacetamide Chemical Properties,Uses,Production

Uses

2-Chloro-N-methylacetamide is an intermediate used to prepare piperidinylamino pyrrolopyrimidines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection.

Synthesis

To methylamine hydrochloride (896 mg, 13.3 mmol) and Na2C03 (5630 mg, 53 mmol) in water (26 mL) was added 2-chloroacetyl chloride (1500 mg, 13.3 mmol). The mixture was stirred at r.t. for lh and extracted with EtOAc (2x). The combined organic layers were dried over Na2S04 and concentrated to provide 2-Chloro-N-methylacetamide (1200 mg, 84%).

References

[1] Journal of the Chemical Society. Perkin Transactions 2, 2000, # 9, p. 1819 - 1831
[2] Patent: WO2016/210330, 2016, A1. Location in patent: Paragraph 0180-0181
[3] Journal of the Chemical Society. Perkin Transactions 1, 2001, # 1, p. 87 - 93

2-Chloro-N-methylacetamide synthesis

593-51-1
79-04-9
96-30-0
Synthesis of 2-Chloro-N-methylacetamide from Methylamine hydrochloride and Chloroacetyl chloride

2-Chloro-N-methylacetamide Preparation Products And Raw materials

Raw materials

Acetamide, N,2-dichloro-N-methyl- Butanamide, 2,2,3,3,4,4,4-heptafluoro-N-methyl- 2-Chloro-N,N-diethylacetamide Methylamine hydrochloride Methylamine
Sodium carbonate Methyl chloroacetate 1-DODECENE Chloroacetyl chloride Ethyl chloroacetate

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Preparation Products

Omethoate N-METHYL-2-PIPERAZIN-1-YLACETAMIDE 2-Dimethylamino-N-methyl-acetamide

2-Chloro-N-methylacetamide Suppliers

Global( 217)Suppliers
Supplier Tel Email Country ProdList Advantage
Creasyn Finechem(Tianjin) Co., Ltd. 022-83946278 13820372920 sales@creasyn.com China 968 68
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Supplier Advantage
Creasyn Finechem(Tianjin) Co., Ltd. 68
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Beijing Ouhe Technology Co., Ltd 60
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57

View Lastest Price from 2-Chloro-N-methylacetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-N-methylacetamide pictures 2026-08-07 2-Chloro-N-methylacetamide
96-30-0
 $1.00-4.00 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd
2-Chloro-N-methylacetamide pictures 2026-06-30 2-Chloro-N-methylacetamide
96-30-0
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Chloro-N-methylacetamide pictures 2021-08-12 2-Chloro-N-methylacetamide
96-30-0
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Chloro-N-methylacetamide Spectrum

2-Chloro-N-methylacetamide(96-30-0)1HNMR

96-30-0(2-Chloro-N-methylacetamide)Related Search:

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N,N-Dimethylacetamide 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide 3,5-DICHLORO-2-PYRIDONE 5-Chlorouracil N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
2-Chloro-N-(2,6-dimethylphenyl)acetamide N-(CHLOROACETYL)-2-(TRIFLUOROMETHYL)ANILINE 2,2,2-TRICHLORO-3'-TRIFLUOROMETHYLACETANILIDE Chloromethyl methyl ether Chloroacetic acid
N-(CHLOROACETYL)-4-FLUOROANILINE Difluorochloromethane 2-Chloro-N,N-diethylacetamide

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OTAVA-BB BB7020410071 N-METHYL-2-CHLOROACETAMIDE chloroacetylmethylamide 2-CHLORO-N-METHYLACETAMIDE 2-chloro-n-methyl-acetamid Acetamide, 2-chloro-N-methyl- alpha-Chloro-N-methylacetamide USAF do-35 usafdo-35 2-chloro-N-methyl-ethanamide 2-chloro-N-methylacetamide(SALTDATA: FREE) 2-Chloro-N-methylacetamide WLN: G1VM1 2-Chloro-N-methylacetamide > 2-Chloro-N-methylacetamide,97% 2-Chloro-N-methylacetamide ISO 9001：2015 REACH 96-30-0 N-Methylchloroacetamide 96-30-0 Acids and Derivatives