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ONCOII

ONCOII structure

CAS No.: 1263564-94-8

Chemical Name:: ONCOII

Synonyms: ONCOII;3-Pyridinecarbonitrile, 6-[[3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino]-2-(cyclohexylamino)-

CBNumber:: CB214907469

Molecular Formula:: C24H25N7O

Molecular Weight:: 427.5

MDL Number:

MOL File:: 1263564-94-8.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:50

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ONCOII Properties

Boiling point	648.925±55.00 °C(Press: 760.00 Torr)(predicted)
Density	1.282±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	1.995±0.10(predicted)

ONCOII Chemical Properties, Uses, Production

Uses

ONCOII is an Mps1 inhibitor with an IC50 of 10.8 nM. The inhibitory activity of ONCOII against Mps1 is affected by naturally occurring mutations in the Mps1 gene, and cells with Mps1 mutations exhibit increased resistance to ONCOII. ONCOII can be used in cancer research[1].

References

[1] Gurden MD, et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15;75(16):3340-54. DOI:10.1158/0008-5472.CAN-14-3272

ONCOII Preparation Products And Raw materials

Raw materials

Preparation Products

ONCOII Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

1263564-94-8 (ONCOII) Related Search:

4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide BAY-1217389 NTRC 00660 MPS1-IN-3 Mps1-IN-5

CFI-400936

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ONCOII 3-Pyridinecarbonitrile, 6-[[3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino]-2-(cyclohexylamino)- 1263564-94-8