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FL442

FL442 structure

CAS No.: 1431166-12-9

Chemical Name:: FL442

Synonyms: FL442;Benzonitrile, 4-(3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazol-3-yl)-2-(trifluoromethyl)-

CBNumber:: CB214907489

Molecular Formula:: C15H13F3N2O

Molecular Weight:: 294.27

MDL Number:

MOL File:: 1431166-12-9.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:50

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FL442 Properties

Boiling point	387.206±52.00 °C(Press: 760.00 Torr)(predicted)
Density	1.397±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

FL442 Chemical Properties, Uses, Production

Uses

FL442 is an Androgen Receptor (AR) modulator. FL442 exhibits strong inhibitory effects in AR-dependent prostate cancer cells, showing similar inhibitory efficiency to traditional antiandrogen drugs Bicalutamide (HY-14249) and Enzalutamide (HY-70002), while maintaining antiandrogenic activity against the AR mutant F876L, which is highly resistant to Enzalutamide. Pharmacokinetic studies of FL442 in mice reveal a long half-life (8 hours), good targeting (prostate tissue), and metabolic stability, and it effectively inhibits LNCaP tumor growth at low plasma concentrations (30 ng/mL)[1].

References

[1] Poutiainen PK, et al. Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator. Mol Cell Endocrinol. 2014 Apr 25;387(1-2):8-18. DOI:10.1016/j.mce.2014.02.008

FL442 Preparation Products And Raw materials

Raw materials

Preparation Products

FL442 Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

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FL442 Benzonitrile, 4-(3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazol-3-yl)-2-(trifluoromethyl)- 1431166-12-9