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AB25583

AB25583 structure

CAS No.: 2565637-94-5

Chemical Name:: AB25583

Synonyms: AB25583;N-(5-((4-Chlorobenzyl)oxy)-1,3,4-thiadiazol-2-yl)-4-(2-methoxyphenyl)nicotinamide;3-Pyridinecarboxamide, N-[5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl]-4-(2-methoxyphenyl)-

CBNumber:: CB214907636

Molecular Formula:: C22H17ClN4O3S

Molecular Weight:: 452.92

MDL Number:

MOL File:: 2565637-94-5.mol

MSDS File:: SDS

Last updated:2026-05-27 23:58:24

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AB25583 Properties

Density	1.400±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	6.276±0.10(predicted)
form	Solid
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

AB25583 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-1208918	AB25583 99.85%	2565637-94-5	5mg	$422	2026-06-04	Buy
ChemScene	CS-1208918	AB25583 99.85%	2565637-94-5	10mg	$628	2026-06-04	Buy
ChemScene	CS-1208918	AB25583 99.85%	2565637-94-5	25mg	$1170	2026-06-04	Buy
ChemScene	CS-1208918	AB25583 99.85%	2565637-94-5	50mg	$1636	2026-06-04	Buy
ApexBio Technology	C8571	AB25583	2565637-94-5	1mg	$139	2026-05-06	Buy

Product number	Packaging	Price	Buy
CS-1208918	5mg	$422	Buy
CS-1208918	10mg	$628	Buy
CS-1208918	25mg	$1170	Buy
CS-1208918	50mg	$1636	Buy
C8571	1mg	$139	Buy

AB25583 Chemical Properties, Uses, Production

Uses

AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research[1].

References

[1] Ito F, et al. Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun. 2024 Aug 14;15(1):7003. DOI:10.1038/s41467-024-51351-4

AB25583 Preparation Products And Raw materials

Raw materials

Preparation Products

AB25583 Suppliers

Global Suppliers ( 8)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2996	55
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9783	55
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59929	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5985	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
Shanghai Anbida Biotechnology Co., Ltd.	021-61629020 18201956406	sales@ambeed.cn	China	7032	58
Guangzhou Ruidi Biotechnology Co., Ltd.	020-82099279 18988941402	sales@ubiochem.com	China	10000	58

Supplier	Advantage
Shanghai Beckham Medical Technology Co., Ltd	55
Tianjin Kailiqi Biotechnology Co., Ltd.	55
Bide Pharmatech Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58
Shanghai Anbida Biotechnology Co., Ltd.	58
Guangzhou Ruidi Biotechnology Co., Ltd.	58

2565637-94-5 (AB25583) Related Search:

Anti-Aging Compound Library Anti-cancer compound library Cell Cycle/DNA Damage Compound Library

AB25583 3-Pyridinecarboxamide, N-[5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl]-4-(2-methoxyphenyl)- N-(5-((4-Chlorobenzyl)oxy)-1,3,4-thiadiazol-2-yl)-4-(2-methoxyphenyl)nicotinamide 2565637-94-5