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HDAC8-IN-12

HDAC8-IN-12 structure

CAS No.: 3028095-13-5

Chemical Name:: HDAC8-IN-12

Synonyms: HDAC8-IN-12;2-Propenamide, N-hydroxy-3-[2-methoxy-4-[(1-methyl-3,6-dioxo-2-piperazinylidene)methyl]phenyl]-

CBNumber:: CB214907818

Molecular Formula:: C16H17N3O5

Molecular Weight:: 331.32

MDL Number:

MOL File:: 3028095-13-5.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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HDAC8-IN-12 Properties

Density	1.364±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	8.98±0.23(predicted)

HDAC8-IN-12 Chemical Properties, Uses, Production

Uses

HDAC8-IN-12 (compound 5k) is a non-hydroxamic acid, selective inhibitor of HDAC8 (IC50: 0.12 nM) and a potent inhibitor of breast cancer. HDAC8-IN-12 triggers anti-tumor immunity by activating T cells, increasing the proportion of M1 macrophages and decreasing the proportion of M2 macrophages. HDAC8-IN-12 (50 mg/kg) exerts tumor suppressive effects in an orthotopic mouse model of breast cancer[1].

References

[1] Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer

HDAC8-IN-12 Preparation Products And Raw materials

Raw materials

Preparation Products

HDAC8-IN-12 Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

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HDAC8-IN-12 2-Propenamide, N-hydroxy-3-[2-methoxy-4-[(1-methyl-3,6-dioxo-2-piperazinylidene)methyl]phenyl]- 3028095-13-5