2,6-Dichloronicotinic acid ethyl ester
- CAS No.
- 58584-86-4
- Chemical Name:
- 2,6-Dichloronicotinic acid ethyl ester
- Synonyms
- ethyl 2,6-dichloronicotinate;Elexacaftor intermediate B;2,6-Dichloronicotinic acid ethyl ester;Ethyl 2,6-dichloropyridine-3-carboxylate;2,6-Dichloropyridin-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester;2,6-dichloro-3-Pyridinecarboxylic acid ethyl ester (9CI ACI);3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester (9CI, ACI)
- CBNumber:
- CB21501258
- Molecular Formula:
- C8H7Cl2NO2
- Molecular Weight:
- 220.05
- MDL Number:
- MFCD09757510
- MOL File:
- 58584-86-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 50.0 to 54.0 °C |
|---|---|
| Boiling point | 286.0±35.0 °C(Predicted) |
| Density | 1.367±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | -4.48±0.10(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C8H7Cl2NO2/c1-2-13-8(12)5-3-4-6(9)11-7(5)10/h3-4H,2H2,1H3 |
| InChIKey | KKYBVLDQTWQETN-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=CC=C1C(OCC)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| HS Code | 2933399990 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,6-Dichloronicotinic acid ethyl ester price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1194 | Ethyl 2,6-Dichloronicotinate >98.0%(GC) | 58584-86-4 | 1g | $121 | 2026-04-30 | Buy |
| TCI Chemical | E1194 | Ethyl 2,6-Dichloronicotinate >98.0%(GC) | 58584-86-4 | 5g | $364 | 2026-04-30 | Buy |
| Apolloscientific | OR303082 | Ethyl 2,6-dichloropyridine-3-carboxylate ≥95% | 58584-86-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR303082 | Ethyl 2,6-dichloropyridine-3-carboxylate ≥95% | 58584-86-4 | 5g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR303082 | Ethyl 2,6-dichloropyridine-3-carboxylate ≥95% | 58584-86-4 | 25g | $28 | 2026-06-04 | Buy |
2,6-Dichloronicotinic acid ethyl ester Chemical Properties, Uses, Production
Synthesis
38496-18-3
64-17-5
58584-86-4
General procedure: 2,6-dichloronicotinic acid (25.5 g, 0.1328 mol) was mixed with ethanol (200 mL) under nitrogen protection and 96% sulfuric acid (1.7 g) was added as catalyst. The reaction mixture was heated to reflux temperature for esterification. Upon completion of the reaction, ethyl 2,6-dichloronicotinate was obtained as a gray solid (24.89 g, 0.1131 mol, 85.2% yield) after conventional post-treatment. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.30 (d, J = 8.1 Hz, 1H), 7.71 (d, J = 8.1 Hz, 1H), 4.33 (q, J = 7.2 Hz, 2H) and 1.30 (t, J = 7.2 Hz, 3H) ppm.
References
[1] Patent: US2015/291629, 2015, A1. Location in patent: Paragraph 0722-0723
[2] Patent: WO2009/150230, 2009, A1. Location in patent: Page/Page column 134
[3] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 65
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4273 - 4288
[5] Patent: US2006/194801, 2006, A1. Location in patent: Page/Page column 38-39
2,6-Dichloronicotinic acid ethyl ester Preparation Products And Raw materials
2,6-Dichloronicotinic acid ethyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangyin Lesen Biotechnology Co., Ltd. | 18961626312 | 125393839@qq.com | China | 228 | 58 |
| Suzhou Joubedii Pharmaceutical Technology Co., Ltd. | 15162465251 | huangcs@jobetterpharm.com | China | 17 | 58 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| DKD Shijiazhuang Chemical Co., Ltd. | 0311-67790228 15531158659 | 2361184479@qq.com | China | 300 | 62 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
View Latest Price from 2,6-Dichloronicotinic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2,6-Dichloronicotinic acid ethyl ester
58584-86-4
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2,6-Dichloronicotinic acid ethyl ester
58584-86-4
|
1KG | 99.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-12-20 | 2,6-Dichloronicotinic acid ethyl ester
58584-86-4
|
$1.00 | 1KG | 99% | 1000KG | Career Henan Chemical Co |
-
- 2,6-Dichloronicotinic acid ethyl ester
58584-86-4
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2,6-Dichloronicotinic acid ethyl ester
58584-86-4
- 99.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,6-Dichloronicotinic acid ethyl ester
58584-86-4
- $1.00
- 99%
- Career Henan Chemical Co
