Methyl 2,6-dichloronicotinate
- CAS No.
- 65515-28-8
- Chemical Name:
- Methyl 2,6-dichloronicotinate
- Synonyms
- Sosimerasib Impurity 2;METHYL 2,6-DICHLORONICOTINATE;2,6-two chloroMethyl nicotinate;Methyl2,6-dichloronicotinate,97%;Methyl 2,6-Dichloronicotinate >methyl 2,6-dichloronicotinate (en);METHYL 2 6-DICHLOROPYRIDINE-3-CARBOXYLA&;Methyl 2,6-dichloropyridin-3-carboxylate;Methyl 2,6-Dichloro-3-pyridinecarboxylate;2,6-Dichloropyridine-3-carboxylic acid methyl ester
- CBNumber:
- CB3500167
- Molecular Formula:
- C7H5Cl2NO2
- Molecular Weight:
- 206.03
- MDL Number:
- MFCD07369794
- MOL File:
- 65515-28-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 2,6-dichloropyridine-3-carboxylate 97% | 656437 | 1g | $95.1 |
| Methyl 2,6-Dichloronicotinate >98.0%(GC) | M2616 | 1g | $28 |
| Methyl 2,6-Dichloronicotinate >98.0%(GC) | M2616 | 5g | $98 |
| Methyl 2,6-dichloropyridine-3-carboxylate | QCA51528 | 100g | $250 |
| Methyl 2,6-dichloronicotinate 98% | OR110405 | 1g | $21 |
| More product size | |||
| Melting point | 56-60 °C(lit.) |
|---|---|
| Boiling point | 270.5±35.0 °C(Predicted) |
| Density | 1.426±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | -4.55±0.10(Predicted) |
| color | White to Light yellow |
| Sensitive | Air Sensitive |
| λmax | 276nm(lit.) |
| InChI | InChI=1S/C7H5Cl2NO2/c1-12-7(11)4-2-3-5(8)10-6(4)9/h2-3H,1H3 |
| InChIKey | IFVVGOJYWCHRCT-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=CC=C1C(OC)=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Methyl 2,6-dichloronicotinate price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 656437 | Methyl 2,6-dichloropyridine-3-carboxylate 97% | 65515-28-8 | 1g | $95.1 | 2023-01-07 | Buy |
| TCI Chemical | M2616 | Methyl 2,6-Dichloronicotinate >98.0%(GC) | 65515-28-8 | 1g | $28 | 2026-04-30 | Buy |
| TCI Chemical | M2616 | Methyl 2,6-Dichloronicotinate >98.0%(GC) | 65515-28-8 | 5g | $98 | 2026-04-30 | Buy |
| Biosynth | QCA51528 | Methyl 2,6-dichloropyridine-3-carboxylate | 65515-28-8 | 100g | $250 | 2026-06-04 | Buy |
| Apolloscientific | OR110405 | Methyl 2,6-dichloronicotinate 98% | 65515-28-8 | 1g | $21 | 2026-06-04 | Buy |
Methyl 2,6-dichloronicotinate Chemical Properties,Uses,Production
Uses
Replacement of chlorides with fluorides using anhydrous nucleophilic fluoride salts generated from potassium fluoride and an arene transfer agent.
Synthesis
67-56-1
38496-18-3
65515-28-8
General procedure for the synthesis of methyl 2,6-dichloronicotinate from methanol and 2,6-dichloronicotinic acid: to a solution of 2,6-dichloronicotinic acid (5.0 g, 26 mmol) in methanol (100 mL) was slowly added thionyl chloride (0.1 mL). The reaction mixture was heated to reflux and kept reacting overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator. The residue was dissolved in ethyl acetate and washed sequentially with saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give methyl 2,6-dichloronicotinate (5.37 g, 100% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ 8.13 (d, J=8.1 Hz, 1H), 7.33 (d, J=8.1 Hz, 1H), 3.94 (s, 3H).
References
[1] Patent: US2005/119251, 2005, A1. Location in patent: Page/Page column 20; 22
[2] Patent: WO2006/14168, 2006, A1. Location in patent: Page/Page column 47
[3] Patent: WO2008/16643, 2008, A2. Location in patent: Page/Page column 233
[4] Patent: WO2006/88836, 2006, A2. Location in patent: Page/Page column 78
[5] Patent: WO2006/88920, 2006, A1. Location in patent: Page/Page column 133-134
Methyl 2,6-dichloronicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
View Lastest Price from Methyl 2,6-dichloronicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | METHYL 2 6-DICHLOROPYRIDINE-3-CARBOXYLA
65515-28-8
|
$1.00 | 1kg | 99% | Career Henan Chemical Co |
-
- METHYL 2 6-DICHLOROPYRIDINE-3-CARBOXYLA
65515-28-8
- $1.00
- 99%
- Career Henan Chemical Co
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