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4-bromo-1-methylpyrazole-3-carboxy acid

CAS No.
84547-84-2
Chemical Name:
4-bromo-1-methylpyrazole-3-carboxy acid
Synonyms
4-bromo-1-methylpyrazole-3-carboxy acid;1-Methyl-4-bromopyrazole-5-carboxylic acid;4-bromo-2-methyl-3-pyrazolecarboxylic acid;4-Bromo-2-methylpyrazole-3-carboxylic acid;4-Bromo-1-methylpyrazole-5-carboxylic Acid;1H-Pyrazole-5-carboxylic acid, 4-bromo-1-methyl-;4-bromo-1-methyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE)
CBNumber:
CB21569904
Molecular Formula:
C5H5BrN2O2
Molecular Weight:
205.01
MDL Number:
MFCD00463982
MOL File:
84547-84-2.mol
Last updated:2025-07-24 18:13:50
Product description Number Pack Size Price
4-BROMO-2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID AldrichCPR R432725 1 unit $30.7
4-BROMO-2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID AldrichCPR R432725 5MG $29.8
4-Bromo-2-methylpyrazole-3-carboxylicacid B697568 1g $75
4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid FB116123 250mg $85
4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid FB116123 1g $75
More product size

4-bromo-1-methylpyrazole-3-carboxy acid Properties

Melting point 235-236 °C
Boiling point 347.4±27.0 °C(Predicted)
Density 1.93±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 1.75±0.37(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HazardClass  IRRITANT

4-bromo-1-methylpyrazole-3-carboxy acid price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R432725 4-BROMO-2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID AldrichCPR 84547-84-2 1 unit $30.7 2025-07-31 Buy
Sigma-Aldrich R432725 4-BROMO-2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID AldrichCPR 84547-84-2 5MG $29.8 2024-03-01 Buy
TRC B697568 4-Bromo-2-methylpyrazole-3-carboxylicacid 84547-84-2 1g $75 2021-12-16 Buy
Biosynth Carbosynth FB116123 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid 84547-84-2 250mg $85 2021-12-16 Buy
Biosynth Carbosynth FB116123 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid 84547-84-2 1g $75 2021-12-16 Buy
Product number Packaging Price Buy
R432725 1 unit $30.7 Buy
R432725 5MG $29.8 Buy
B697568 1g $75 Buy
FB116123 250mg $85 Buy
FB116123 1g $75 Buy

4-bromo-1-methylpyrazole-3-carboxy acid Chemical Properties,Uses,Production

Synthesis

4-Bromo-1-methylpyrazole

15803-02-8

Carbon dioxide

124-38-9

4-bromo-1-methylpyrazole-3-carboxy acid

84547-84-2

1. 600 ml of anhydrous THF was added to a 2L reaction flask under argon protection. 2. 65.4 g of diisopropylamine was added and the reaction system was subsequently cooled to -78 °C via a dry ice acetone bath. 3. 258 ml of 2.5 M n-butyllithium solution was slowly added dropwise at 0 °C. After the dropwise addition, the reaction temperature was raised to 0 °C and maintained for 0.5 h. The reaction system was then cooled to -78 °C again. 4. 80.0 g of 1-methyl-4-bromopyrazole was slowly added dropwise at -78 °C, and after the dropwise addition was completed, the reaction temperature was maintained at -78 °C for 1 hour. 5. dry carbon dioxide gas was passed into the reaction system until TLC detection showed that the reaction was complete. 6. The pH of the reaction solution was slowly adjusted to 2-3 with 1N HCl, at which time a large amount of white solid was precipitated. 7. The reaction mixture was cooled at 0 °C for 3 h, followed by filtration to collect the white solid. 8. The resulting solid was dried at 40 °C for 16 h to give 77.3 g of white solid compound 22 (4-bromo-1-methyl-1H-pyrazole-5-carboxylic acid).

References

[1] Patent: CN108264520, 2018, A. Location in patent: Paragraph 0261; 0262; 0263; 0264; 0265

15803-02-8
124-38-9
84547-84-2
Synthesis of 4-bromo-1-methylpyrazole-3-carboxy acid from 4-Bromo-1-methylpyrazole and Carbon dioxide

4-bromo-1-methylpyrazole-3-carboxy acid Preparation Products And Raw materials

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View Lastest Price from 4-bromo-1-methylpyrazole-3-carboxy acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-bromo-1-methylpyrazole-3-carboxy acid pictures 2019-07-06 4-bromo-1-methylpyrazole-3-carboxy acid
84547-84-2
US $1.00 / KG 1KG 98% 100KG Career Henan Chemical Co

4-bromo-1-methylpyrazole-3-carboxy acid Spectrum

1-Methyl-4-bromopyrazole-5-carboxylic acid 4-bromo-1-methylpyrazole-3-carboxy acid 4-bromo-1-methyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE) 4-Bromo-2-methylpyrazole-3-carboxylic acid 4-bromo-2-methyl-3-pyrazolecarboxylic acid 1H-Pyrazole-5-carboxylic acid, 4-bromo-1-methyl- 4-Bromo-1-methylpyrazole-5-carboxylic Acid 84547-84-2