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(R)-Glycidyl butyrate

(R)-Glycidyl butyrate Structure
(R)-Glycidyl butyrate structure
CAS No.
60456-26-0
Chemical Name:
(R)-Glycidyl butyrate
Synonyms
(R)-Oxiran-2-ylMethyl butyrate;OXIRAN-2-YLMETHYL BUTYRATE;(R)-(-)-GLYCIDYL BUTYRATE;(2R)-Oxiran-2-ylmethyl butanoate;Torezolid-18;(R)-Glycidyl butyrat;R-glycicyl butanoate;Tedizolid Impurity 44;(R)-GLYCIDYL BUTYRATE;Tedizolid Impurity 61
CBNumber:
CB2164281
Molecular Formula:
C7H12O3
Molecular Weight:
144.17
MDL Number:
MFCD00075120
MOL File:
60456-26-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:58:21
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(R)-Glycidyl butyrate Properties

alpha -30 º (c=neat)
Boiling point 197 °C(lit.)
Density 1.032 g/mL at 20 °C(lit.)
refractive index n20/D 1.428(lit.)
Flash point 185 °F
storage temp. Inert atmosphere,2-8°C
solubility Chloroform, Ethyl Acetate
form Liquid
color Clear colorless to slightly yellow
Specific Gravity 1.018
optical activity [α]25/D 31°, neat
Water Solubility insoluble
BRN 5246881
InChI 1S/C7H12O3/c1-2-3-7(8)10-5-6-4-9-6/h6H,2-5H2,1H3/t6-/m1/s1
InChIKey YLNSNVGRSIOCEU-ZCFIWIBFSA-N
SMILES CCCC(=O)OC[C@H]1CO1
CAS DataBase Reference 60456-26-0(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H315-H319-H334-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-42/43
Safety Statements  23-36/37-45-36/37/39-26
RIDADR  2810
WGK Germany  3
F  10-21
HazardClass  6.1
PackingGroup  III
HS Code  29156000
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 0

(R)-Glycidyl butyrate price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 338125 (R)-(?)-Glycidyl butyrate 96% 60456-26-0 5g $41.6 2026-04-30 Buy
TCI Chemical G0282 (R)-Glycidyl Butyrate >98.0%(GC) 60456-26-0 5g $63 2026-04-30 Buy
TCI Chemical G0282 (R)-Glycidyl Butyrate >98.0%(GC) 60456-26-0 25g $186 2026-04-30 Buy
Usbiological 278437 (R)-(-)-Glycidyl butyrate Asreported 60456-26-0 50g $340 2026-06-03 Buy
Usbiological 278437 (R)-(-)-Glycidyl butyrate Asreported 60456-26-0 100g $460 2026-06-03 Buy
Product number Packaging Price Buy
338125 5g $41.6 Buy
G0282 5g $63 Buy
G0282 25g $186 Buy
278437 50g $340 Buy
278437 100g $460 Buy

(R)-Glycidyl butyrate Chemical Properties, Uses, Production

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-Glycidyl butyrate is a reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraul ic fluids; epoxy resin diluent.

Uses

(2R)-2-Oxiranylmethyl Ester Butanoic Acid is a reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.

Reactions

Research demonstrate that phosphonium tetraborane Lewis pair (P4B-Br) enables the ring-opening polymerization (ROP) of (R)-Glycidyl butyrate (RGB) at room temperature with a turnover number (TON) of 200, yielding α-Br/ω-OH and α-OH/ω-OH terminated poly(glycidyl butyrate) (PRGB)[4].

Synthesis

Butanoic acid, (2S)-3-chloro-2-hydroxypropyl ester

890051-54-4

(R)-Glycidyl butyrate

60456-26-0

(S)-3-Chloro-1,2-propanediol 1-(n-butyrate) (50.0 g, 0.277 mol, optical purity 99% ee) was used as a raw material and dissolved in 1,2-dichloroethane (200 ml). Potassium tert-butoxide (32.6 g, 0.291 mol) was added to the solution under cooling conditions in an ice bath. The reaction mixture was stirred for 1 hour. After completion of the reaction, the mixture was transferred to a partition funnel and washed twice with water (200 ml). The organic layer was concentrated under reduced pressure to give (R)-glycidyl butyrate (28.7 g, 72.0% yield). The optical purity of the target product was 99% ee as determined by HPLC.

References

[1] Letters in Organic Chemistry,  2011,  vol. 8,  # 4,  p. 242 - 243
[2] Tetrahedron Letters,  2006,  vol. 47,  # 20,  p. 3453 - 3457
[3] Patent: US2004/24254,  2004,  A1. Location in patent: Page 6
[4] Li, L., Liu, M., Wang, Z., Wang, X., & Li, Z. (2026). Synthesis of glycerol-based (co)polyethers via ring-opening polymerization of glycidyl butyrate catalyzed by a one-component phosphonium tetraborane Lewis pair. Polymer Chemistry, 17 8, Pages 856-864. https://doi.org/10.1039/d5py01129a

(R)-Glycidyl butyrate synthesis

106-31-0
60456-23-7
60456-26-0
Synthesis of (R)-Glycidyl butyrate from Butyric anhydride and (S)-Oxiranemethanol

(R)-Glycidyl butyrate Preparation Products And Raw materials

Raw materials

(S)-Oxiranemethanol Toluene Triethylamine Butyryl chloride Butanoic acid, (2S)-3-chloro-2-hydroxypropyl ester
Butyric anhydride 1,2-Dichloroethane Potassium tert-butoxide Glycidyl butyrate (S)-(+)-Glycidyl butyrate

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Preparation Products

Torezolid Butanoic acid, (2S)-3-chloro-2-hydroxypropyl ester (-)-D-Glycerol 1-butyrate (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Delpazolid
(5R)-3-(4-Bromo-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one (R)-5-(hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one

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(R)-Glycidyl butyrate Suppliers

Global Suppliers ( 366)
Supplier Tel Email Country ProdList Advantage
Shanghai KeLy Bio-Pharmaceutical Co., Ltd. 13816253073 lige@kelybiopharm.com China 127 58
Changzhou Huaren Chemical Co., Ltd 0519-88103998, 13646148298, 88103997, 88122965,88100916 13646148298;051988100916; amy.zhou@huarenchem.com China 51 63
Sichuan Hainuowei Technology Co. Ltd. 13708085536 13708085536 hanovichem@163.com China 3268 56
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Shanghai KeLy Bio-Pharmaceutical Co., Ltd. 58
Changzhou Huaren Chemical Co., Ltd 63
Sichuan Hainuowei Technology Co. Ltd. 56
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66

View Latest Price from (R)-Glycidyl butyrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-(-)-Glycidyl butyrate pictures 2026-09-15 (R)-(-)-Glycidyl butyrate
60456-26-0
 $10.00 1kg 98.0% 10 tons Nantong Provichem Biotech Co., Ltd.
(R)-Glycidyl butyrate pictures 2026-09-02 (R)-Glycidyl butyrate
60456-26-0
 $1.00-3.00 1kg 99% Henan Fengda Chemical Co., Ltd
(R)-Glycidyl butyrate pictures 2026-06-30 (R)-Glycidyl butyrate
60456-26-0
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

(R)-Glycidyl butyrate Spectrum

(R)-Glycidyl butyrate(60456-26-0)1HNMR(R)-Glycidyl butyrate(60456-26-0)IR(R)-Glycidyl butyrate(60456-26-0)FT-IR

60456-26-0 ((R)-Glycidyl butyrate) Related Search:

Glycerol GLYCERYL MONOSTEARATE Allyl glycidyl ether Butyric Acid Monostearin
Glycidyl acrylate Sucrose acetate isobutyrate Sodium Butyrate Dimethyl 2,2'-azobis(2-methylpropionate) Glycidol
Triacetin (S)-GLYCIDYL BUTYRATE,(S)-(-)-GLYCIDYL BUTYRATE,(S)-(+)-GLYCIDYL BUTYRATE,(S)-(+)-GLYCIDYL BUTYRATE , EE 98%,(S)-(+)-Glycidyl butyrate, 98%, ee 98% Titanium tetraisopropanolate Titanium ethoxide Torezolid
bis(((R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl) hydrogen phosphate Tedizolid Impurity 36 Tedizolid Impurity 39

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Tedizolid Impurity 44 Butanoic acid, (2R)-oxiranylMethyl ester Butanoic acid, oxiranylMethyl ester, (R)- (R)-(-)-Glycidyl butyrate, (R)-(-)-Glycidyl butanoate (2R)-2-Oxiranylmethyl Ester Butanoic Acid (R)-Glycidyl butyrat (R)-Glycidyl butyrate, 92-94% 10GR (R) - glycidyl ester of butyric acid (R)-Glycidyl Butyrate,99%e.e. (2R)-Oxiran-2-ylmethyl pentanoate Tedizolidted Impurity 2 (2R)-(-)-GLYCIDYL BUTYRATE BUTYRIC ACID (R)-GLYCIDYL ESTER (R)-(-)-GLYCIDYL BUTYRATE (R)-GLYCIDYL BUTYRATE (R)-OXIRANE-2-METHANOL BUTYRATE R(-)-OXIRANE-2-METHANOL BUTYRATE (R)-4-GLYCIDYL BUTYRATE (R)-2,3-EPOXYPROPYL N-BUTYRATE R-glycicyl butanoate (R)-GlycidylButyrate(IntermediateForLinezolid) Intermediate For Linezolid (R)-Glycidyl butyrate, 92-94% OXIRAN-2-YLMETHYL BUTYRATE,(R)-GLYCIDYL BUTYRATE (2R)-Oxiran-2-ylmethyl butyrate Torezolid-18 Butanoic acid,(2R)-2-oxiranylmethyl ester (R)-GlycidylButyrate> Tedizolid Impurity 61 (R)-(?)-Glycidyl butyrate (-)-[(2R)-Oxiran-2-yl]methyl butanoate (2R)-Oxiran-2-ylmethyl butanoate (R)-Oxiran-2-ylMethyl butyrate OXIRAN-2-YLMETHYL BUTYRATE 60456-26-0 C7H12O3 Organic Building Blocks Chiral Building Blocks Oxiranes Simple 3-Membered Ring Compounds Glycidyl Compounds, etc. (Chiral) Epoxides Asymmetric Synthesis Chiral Compound Oxiranes Simple 3-Membered Ring Compounds Synthetic Organic Chemistry Esters Ring Systems CHIRAL COMPOUNDS Small molecule chiral API intermediates Chiral Building Blocks Glycidyl Compounds, etc. (Chiral)