Glycidol
- CAS No.
- 556-52-5
- Chemical Name:
- Glycidol
- Synonyms
- Oxiranemethanol;2,3-EPOXY-1-PROPANOL;oxiranyl-methanol;GLYCEROLGLYCIDE;2,3-Epoxypropanol;(±)-Glycidol;GLYCEROGLYCIDE;(+/-)-GLYCIDOL;Glycidyl alcohol;OXYRANYL METHANOL
- CBNumber:
- CB5338946
- Molecular Formula:
- C3H6O2
- Molecular Weight:
- 74.08
- MDL Number:
- MFCD00005147
- MOL File:
- 556-52-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -54 °C |
|---|---|
| Boiling point | 61-62 °C/15 mmHg (lit.) |
| Density | 1.117 g/mL at 25 °C (lit.) |
| vapor density | 2.15 (vs air) |
| vapor pressure | 0.9 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | 178 °F |
| storage temp. | -20°C |
| solubility | Soluble in acetone, alcohol, benzene, chloroform, and ether (Weast, 1986) |
| pka | 14.62±0.10(Predicted) |
| form | Powder, Crystals or Chunks |
| color | White to light yellow-beige |
| Water Solubility | soluble |
| Merck | 13,4503 |
| BRN | 383562 |
| Henry's Law Constant | 1.7×103 mol/(m3Pa) at 25℃, HSDB (2015) |
| Exposure limits |
ACGIH:TLV-TWA 2 ppm (6.1 mg/m3) OSHA:PEL-TWA 50 ppm (150 mg/m3) NIOSH:REL-TWA 25 ppm |
| Stability | Stability Stable, but may explode on contact with strong acids, strong bases, heavy metals, heavy metal salts. May decompose on exposure to water or moist air. |
| InChI | 1S/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2 |
| InChIKey | CTKINSOISVBQLD-UHFFFAOYSA-N |
| SMILES | OCC1CO1 |
| LogP | -0.95 at 25℃ |
| Toxicology and Carcinogenesis | Toxicology and Carcinogenesis Studies of Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies) |
| CAS DataBase Reference | 556-52-5(CAS DataBase Reference) |
| EWG's Food Scores | 6 |
| FDA UNII | S54CF1DV9A |
| Proposition 65 List | Glycidol |
| NIST Chemistry Reference | Glycidol(556-52-5) |
| IARC | 2A (Vol. 77) 2000 |
| EPA Substance Registry System | Glycidol (556-52-5) |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312-H315-H319-H330-H335-H341-H350-H360F |
| Precautionary statements | P202-P280-P301+P312-P302+P352+P312-P304+P340+P310-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | T |
| Risk Statements | 45-60-21/22-23-36/37/38-68 |
| Safety Statements | 53-45-36/37-26 |
| RIDADR | UN 2810 6.1/PG 3 |
| OEB | A |
| OEL | TWA: 25 ppm (75 mg/m3) |
| WGK Germany | 3 |
| RTECS | UB4375000 |
| F | 10-21 |
| Autoignition Temperature | 780 °F |
| Hazard Note | Toxic |
| TSCA | TSCA listed |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29109000 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 4 Dermal Acute Tox. 4 Oral Carc. 1B Eye Irrit. 2 Muta. 2 Repr. 1B Skin Irrit. 2 STOT SE 3 |
| Hazardous Substances Data | 556-52-5(Hazardous Substances Data) |
| Toxicity | Acute oral LD50 for mice 431 mg/kg, rats 420 mg/kg (quoted, RTECS, 1985). |
| IDLA | 150 ppm |
| REACH Registrations | Active |
| Limited Quantities | 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
Glycidol price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001048 | Levodropropizine impurity C European Pharmacopoeia (EP) Reference Standard | 556-52-5 | 420 mg | $175 | 2026-04-30 | Buy |
| Sigma-Aldrich | G5809 | Glycidol 96% | 556-52-5 | 2.5kg | $834 | 2026-04-30 | Buy |
| Sigma-Aldrich | 74595 | (±)-Glycidol analytical standard | 556-52-5 | 100mg | $81.3 | 2026-04-30 | Buy |
| TRC | TRC-G615703-25G | Glycidol (~90%) | 556-52-5 | 25g | $109 | 2026-06-03 | Buy |
| TRC | TRC-G615703-1G | Glycidol (~90%) | 556-52-5 | 1g | $64 | 2026-06-03 | Buy |
Glycidol Chemical Properties,Uses,Production
Description
Glycidol is a chiral molecule with epoxide and primary alcohol functional groups. It is racemic mixture and exists in the dextrorotatory and the levorotatory enantiomeric forms. Several synthetic methods are available for preparation of glycidol. However, it is commercially prepared from the epoxidation of allyl alcohol with hydrogen peroxide and a catalyst (tungsten or vanadium), or from the reaction of epichlorohydrin with caustic. Glycidol has been used in the industrial synthesis of pharmaceutical products since the 1970s. However, its use for research purposes has been reported since 1956. Available information indicates that glycidol is manufactured by several companies in Japan, Germany, and the United States.
Chemical Properties
colourless liquid
Chemical Properties
Glycidol is a colorless liquid.
Uses
Glycidol is used as a stabilizer for natural oilsand vinyl polymers, as a demulsifier, and asa leveling agent for dyes.
Uses
Stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.
Uses
Glycidol is a Stabilizer in the manufacture of vinyl polymers; chemical intermediate in preparation of glycerol, glycidyl ethers, esters, and amines; in pharmaceuticals; in sanitary chemicals.
Definition
an epoxide
General Description
Odorless clear colorless liquid.
Air & Water Reactions
Sensitive to moisture.
Reactivity Profile
Glycidol is sensitive to moisture. Glycidol is also sensitive to light. Glycidol may polymerize if heated above room temperature. Glycidol may darken on storage. Stability studies of Glycidol stored for two week protected from light indicated definite decomposition at 140° F, and strongly indicated instability at 77° F. A solution of Glycidol in water was found to be unstable when stored at room temperature, even after one day in the dark. Glycidol is incompatible with strong oxidizers. Glycidol will undergo explosive decomposition in the presence of strong acids or bases, salts (such as aluminum chloride, iron(III)chloride or tin(IV) chloride) or metals (such as copper and zinc). Glycidol is also incompatible with nitrates. Glycidol will attack some forms of plastics, rubber and coatings.
Hazard
Toxic material. Probable carcinogen.
Health Hazard
Glycidol is an eye, lung, and skin irri-tant. The pure compound caused severebut reversible corneal injury in rabbit eyes(ACGIH 1986). Exposure to its vapor causedirritation of lung in mice, resulting in pneu-monitis. There is no evidence of any cumula-tive toxicity. From the limited toxicity data,it appears that the health hazard to humansfrom its exposure is, primarily, respiratoryirritation, stimulation of the central nervoussystem, and depression.
Glycidol is mutagenic, testing positive inthe histidine reversion–Ames test. There isno report of its carcinogenic action. Oraland intraperitoneal administration of gly-cidol in rats showed harmful effects onfertility.
Fire Hazard
Glycidol is combustible.
Flammability and Explosibility
Non flammable
Safety Profile
Confirmed carcinogen with carcinogenic data reported. Poison by intraperitoneal route. Moderately toxic by ingestion, inhalation, and sh contact. Experimental teratogenic and reproductive effects. A skin irritant. Human mutation data reported. Animal experiments suggest somewhat lower toxicity than for related epoxy compounds. Readdy absorbed through the skin. Causes nervous excitation followed by depression. Explodes when heated or in the presence of strong acids,bases, metals (e.g., copper, zinc), and metal salts (e.g., aluminum chloride, iron(II1) chloride, tin(Iy chloride). When heated to decomposition it emits acrid smoke and fumes. See also DIGLYCIDYL ETHER.
Synthesis
A method for directly preparing glycidol from glycerol is shown as following steps: putting a mixed solvent in a glass or enamel reaction kettle, adding glycerol to the mixed solvent, controlling the concentration of glycerol in the reaction liquid within the range of 0.5-3.0 mol/L, then adding a catalyst, and controlling the quantity of the catalyst to account for 0.01-0.20 of the weight of the glycerol; increasing the temperature of the mixed reaction liquid to the range of 40-100 ℃ under stirring condition and reacting at a constant temperature for 2-20 hours; and after reaction, filtering off the catalyst from the reaction liquid, then distilling the mixed reaction liquid, and collecting the fraction in the range of 160-161 ℃, thereby obtaining the product 2,3-glycidol.
Potential Exposure
Glycidol is used as an intermediate in the synthesis of glycerol, glycidyl ethers, esters, and amines.
Carcinogenicity
Glycidol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
Chemical/Physical. May hydrolyze in water forming glycerin (Lyman et al., 1982).
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.
Toxicity evaluation
Glycidol is a small molecule possessing a chemically reactive epoxide group. Therefore, it acts as a direct alkylating agent. Nucleophilic bioactive compounds such as glutathione react readily with glycidol. Glycidol decreases glutathione content in rat liver by direct binding to the glutathione. In vitro experiments revealed that glycidol reacts with purified DNA to form the DNA adducts. This is likely to be responsible for the genotoxic activity of the compound without a requirement for metabolic activation.
Incompatibilities
May form explosive mixture with air. Violent reaction with strong oxidizers, nitrates. Decomposes on contact (especially in the presence of heat) with strong acids, strong bases, water, metal salts, e.g., alu minum chloride, ferric chloride, and tin chloride), or metals (copper and zinc), causing fire and explosion hazard. Contact with barium, lithium, sodium, magnesium, and tita nium may cause polymerization. Attacks some plastics, rubber, and coatings.
Waste Disposal
Concentrated waste contain ing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.
Glycidol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiaxing Deyi Chemical Co., Ltd | 0573-85866609 13325730825 | jiaxingshidy@163.com | China | 7898 | 58 |
| Changzhou Huaren Chemical Co., Ltd | 0519-88103998, 13646148298, 88103997, 88122965,88100916 13646148298;051988100916; | amy.zhou@huarenchem.com | China | 51 | 63 |
| Guangdong Qianjin Chemical Reagent Co., Ltd. | 0751-2818792 13435114148 | 3128240096@qq.com | China | 2985 | 58 |
| Changzhou Run-chem Biotech Co., ltd | 15061933924 | 3301839366@qq.com | China | 932 | 58 |
| Zhongshan Dixin Chemical Co., Ltd | 19849939632; 19849939632 | 2470479589@qq.com | China | 1748 | 58 |
| Shanghai Likas Industrial Co., LTD | 19821976800 | chinalikas@163.com | China | 457 | 58 |
| Jiangsu Greature Bio-Medicine Co., Ltd. | 0512-85557988 18662338937 | frank.wang@greature.com.cn | China | 145 | 58 |
| Guangdong Baike Reagent Co., Ltd. | 13532366769 13686183698 | 1003878212@qq.com | China | 2908 | 58 |
| Suzhou Senfeida Chemical Material Co., Ltd. | 512-66387919 13862111431 | sales2@senfeida.com | China | 298 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
Related articles
- Glycidol: both an epoxide and an alcohol
- Glycidol is an epoxide and an alcohol, which has a chiral center, but it is generally produced and used as the racemic mixture....
- Mar 17,2025
View Lastest Price from Glycidol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-13 | Glycidol
556-52-5
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | Glycidol
556-52-5
|
$50.00-100.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-07-29 | Glycidol
556-52-5
|
$6.00 | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd |
