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Tetrakis(hydroxymethyl)phosphonium chloride

Tetrakis(hydroxymethyl)phosphonium chloride Structure
Tetrakis(hydroxymethyl)phosphonium chloride structure
CAS No.
124-64-1
Chemical Name:
Tetrakis(hydroxymethyl)phosphonium chloride
Synonyms
THPC;SQJGLHL;THPS-UPC;meso-THPC;pyrosettkc;nci-c55061;AURORA KA-1157;HISHICOLIN THPC;tetramethylolphosphonium chloride;tetrakis(hydroxymethyl)phosphonium
CBNumber:
CB2166508
Molecular Formula:
C4H12ClO4P
Molecular Weight:
190.56
MDL Number:
MFCD00031687
MOL File:
124-64-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:58:29
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Tetrakis(hydroxymethyl)phosphonium chloride Properties

Melting point 154°C
Boiling point 115°C/760mmHg
Density 1.341 g/mL at 25 °C
vapor pressure 0Pa at 25℃
refractive index n20/D 1.512
form Solution
pka 6.05[at 20 ℃]
color Clear light pink or yellow-green
Water Solubility >=10 g/100 mL at 20 ºC
BRN 3631669
InChI InChI=1S/C4H12O4P.ClH/c5-1-9(2-6,3-7)4-8;/h5-8H,1-4H2;1H/q+1;/p-1
InChIKey AKXUUJCMWZFYMV-UHFFFAOYSA-M
SMILES [P+](CO)(CO)(CO)CO.[Cl-]
LogP -9.8
CAS DataBase Reference 124-64-1(CAS DataBase Reference)
FDA UNII 58WB2XCF8I
EPA Substance Registry System Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1)
UNSPSC Code 12352101
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)Health Hazard (GHS08)Environment (GHS09)
GHS05,GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H290-H301+H311-H314-H317-H360FD-H410
Precautionary statements  P201-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  T,N
Risk Statements  21-25-38-41-42/43-51/53
Safety Statements  22-26-36/37/39-45-60-61-23
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS  TA2450000
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
HS Code  29319019
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1
Met. Corr. 1
Repr. 1B
Skin Corr. 1B
Skin Sens. 1
Hazardous Substances Data 124-64-1(Hazardous Substances Data)
Toxicity mammal (species unspecified),LD50,oral,400mg/kg (400mg/kg),Kobunshi. High Polymers. Vol. 24, Pg. 788, 1975.
REACH Registrations Active
NFPA 704
1
3 0

Tetrakis(hydroxymethyl)phosphonium chloride price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 404861 Tetrakis(hydroxymethyl)phosphonium chloride solution 80% in H2O 124-64-1 100ml $82.9 2026-04-30 Buy
Sigma-Aldrich 404861 Tetrakis(hydroxymethyl)phosphonium chloride solution 80% in H2O 124-64-1 500ml $241 2026-04-30 Buy
TCI Chemical T0607 Tetrakis(hydroxymethyl)phosphonium Chloride (ca. 80% in Water) 124-64-1 25mL $19 2021-12-16 Buy
Biosynth AAA12464 Tetrakis(hydroxymethyl)phosphanium chloride 124-64-1 100g $900 2026-06-04 Buy
Chem-Impex 37307 Tetrakis(hydroxymethyl)phosphonium chloride solution (80% in H2O) 76-84%(Assaybytitration) 124-64-1 25ML $25 2026-05-19 Buy
Product number Packaging Price Buy
404861 100ml $82.9 Buy
404861 500ml $241 Buy
T0607 25mL $19 Buy
AAA12464 100g $900 Buy
37307 25ML $25 Buy

Tetrakis(hydroxymethyl)phosphonium chloride Chemical Properties, Uses, Production

Chemical Properties

Clear light pink or yellow-green solution

Uses

Flame-retarding agent for cotton fabrics. May be used in combination with triethylolamine and urea (Roxel process) or with triethanolamine and tris(1-aziridinyl) phosphine oxide.

Uses

Tetrakis(hydroxymethyl)phosphonium chloride solution (80% in H2O) has been used as a reducing agent and stabilizing ligand for the synthesis of gold nanoparticles (AuNPs) from gold(III) chloride trihydrate (HAuCl4.3H2O). It is a tetra-functional, amine-reactive, aqueous crosslinker that can be used for tuning the properties of protein-based hydrogels for 3D cell encapsulation applications.

Definition

A crystalline compound made by the reaction of phosphine, formaldehyde, and hydrochloric acid.

General Description

Clear slightly viscous,colorless to yellow liquid (20% H2O solution).

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

Tetrakis(hydroxymethyl)phosphonium chloride reacts vigorously with oxidizers and alkalis. Reacts with cellulose.

Health Hazard

ACUTE/CHRONIC HAZARDS: Tetrakis(hydroxymethyl)phosphonium chloride may be corrosive. When heated to decomposition, it may emit very toxic fumes of POx, hydrogen chloride and bis(chloromethyl)ether. Decomposition of Tetrakis(hydroxymethyl)phosphonium chloride in an aqueous environment may produce phosphine, formaldehyde and hydrogen chloride.

Fire Hazard

Tetrakis(hydroxymethyl)phosphonium chloride is probably combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from AcOH and dry it at 100o in a vacuum. An 80% w/v aqueous solution has d4 1.33 [Reeves J Am Chem Soc 77 3923 1955]. [Beilstein 1 IV 3062.]

Tetrakis(hydroxymethyl)phosphonium chloride synthesis

50-00-0
124-64-1
Synthesis of Tetrakis(hydroxymethyl)phosphonium chloride from Formaldehyde

Tetrakis(hydroxymethyl)phosphonium chloride Preparation Products And Raw materials

Raw materials

Formaldehyde

Preparation Products

Tetrakis(hydroxymethyl)phosphonium chloride Suppliers

Global Suppliers ( 291)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing dtftchem Technology Co., Ltd. 010-60275820 13031183356 elainezt@sina.com China 1386 62
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Secco work (Beijing) chemical technology co., LTD 0566-8928158 343367102@QQ.COM China 359 54
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
TCI (Shanghai) Development Co., Ltd. 81
Beijing dtftchem Technology Co., Ltd. 62
Energy Chemical 61
Secco work (Beijing) chemical technology co., LTD 54
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Sichuan Kulinan Technology Co., Ltd 57

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View Latest Price from Tetrakis(hydroxymethyl)phosphonium chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tetrakis(hydroxymethyl)phosphonium chloride pictures 2026-09-17 Tetrakis(hydroxymethyl)phosphonium chloride
124-64-1
 0.99 RongNa Biotechnology Co.,Ltd
Tetrakis(hydroxymethyl)phosphonium chloride pictures 2026-08-07 Tetrakis(hydroxymethyl)phosphonium chloride
124-64-1
 $1.00-4.00 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd
Tetrakis (hydroxymethyl) Phosphonium Chloride pictures 2026-05-28 Tetrakis (hydroxymethyl) Phosphonium Chloride
124-64-1
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD

Tetrakis(hydroxymethyl)phosphonium chloride Spectrum

Tetrakis(hydroxymethyl)phosphonium chloride(124-64-1)MSTetrakis(hydroxymethyl)phosphonium chloride(124-64-1)IR1Tetrakis(hydroxymethyl)phosphonium chloride(124-64-1)Raman

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THPS-UPC TETRA(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE tetramethylolphosphonium chloride nci-c55061 Phosphonium,tetrakis(hydroxymethyl)-,chloride pyrosettkc tetrakis-(hydroxymethyl)fosfoniumchlorid tetrakis(hydroxymethyl)phosphochloride tetrakis(hydroxymethyl)-phosphoniuchloride tetrakis(hydroxymethyl)phosphonium TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLOR IDE, 80% SOLUTION IN WATER TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLOR IDE, 80% IN H2O Tetrakis(Hydroxymethyl)Phosphorium Chloride TetrakisHydroxymethylPhosphoniumChloride(Thpc) AURORA KA-1157 tetrakis(hydroxymethyl)phosphonium chloride solution HISHICOLIN THPC Tetrakis(hydroxymethyl)phosphonium Chloride (ca. 80% in Water) TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE, CA. 80% SOLUTION IN WATER meso-THPC TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE: 80% IN WATER Tetrakis(HydroxyMethyl) PosphoniuM Chloride Tetrakis(hydroxyMethyl)phosphoniuM chloride solution,~80% in H2O PhosphoniuM,tetrakis(hydroxyMethyl)-, chloride (1:1) Tetrakis(hydroxymethyl)phosphonium chloride, 80% solution in H2O Tetrakis(hydroxymethyl) phosphonium chloride (70-80 % in water) SQJGLHL Tetrakis(hydroxymethyl)phosphanium chloride Tetrakis(hydroxymethyl)phosphonium chloride solution,~8% in H2O Tetramethyl phosphorus chloride (THPC) Tetrakis(hydroxymethyl)phosphanium chloride,80% in water Tetramethylolphosphonium chloride(THPC) THPC Tetrahydroxymethyl phosphate chloride 124-64-1 124-61-1 24-64-1 HOCH24PCl C4H12O4PClC4H12ClO4P CH2OH4PCl C4H12O4PCl C4H12ClO4P C10H24O12P2 Phosphonium Compounds Synthetic Reagents Phosphonium Salts Phase Transfer Catalysts texitile auxiliary agents Phosphonium Compounds Greener Alternatives: Catalysis Phase Transfer Catalysts Phosphonium Salts Phosphonium Salts