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tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate structure

CAS No.: 723286-80-4

Chemical Name:: tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

Synonyms: 7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine;tert-butyl 3-broMo-5;3-a]pyrazine-7(8H)-carboxylate;7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-;7-Boc-3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine;3-Bromo-7-Boc-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine;tert-butyl 3-bromo-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine...;7-N-Boc-3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine;3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate;tert-butyl 3-broMo-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate

CBNumber:: CB2168274

Molecular Formula:: C10H15BrN4O2

Molecular Weight:: 303.16

MDL Number:: MFCD08448169

MOL File:: 723286-80-4.mol

Last updated:2026-09-12 18:50:24

Request For Quotation

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate Properties

Boiling point	430.4±55.0 °C(Predicted)
Density	1.62±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	0.55±0.20(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H335-H302+H312+H332-H315
Precautionary statements	P280-P301+P312-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22-20/22
Safety Statements	36/37
HS Code	29339900

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	SC2621	TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE 95%	723286-80-4	1G	$99	2026-04-30	Buy
AstaTech	SC2621	TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE 95%	723286-80-4	5G	$299	2026-04-30	Buy
AstaTech	SC2621	TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE 95%	723286-80-4	10G	$527	2026-04-30	Buy
Apolloscientific	OR470061	7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine 97%	723286-80-4	100mg	$21	2026-06-04	Buy
Apolloscientific	OR470061	7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine 97%	723286-80-4	250mg	$25	2026-06-04	Buy

Product number	Packaging	Price	Buy
SC2621	1G	$99	Buy
SC2621	5G	$299	Buy
SC2621	10G	$527	Buy
OR470061	100mg	$21	Buy
OR470061	250mg	$25	Buy

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate Chemical Properties, Uses, Production

Chemical Properties

White solid

Synthesis

5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER

723286-79-1

TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE

723286-80-4

The general procedure for the synthesis of 7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine using 7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine as a starting material was as follows: 7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine (1 g ) was dissolved in chloroform (20 mL) and sodium bicarbonate (688 mg) and N-bromosuccinimide (873 mg) were added sequentially at 0 °C in an ice bath. The reaction mixture was stirred at 0 °C for 2 hours. Upon completion of the reaction, the reaction solution was brought back to room temperature and the reaction was quenched by the addition of an appropriate amount of water, followed by three extractions with chloroform. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography to afford the target compound 7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine (693 mg, 51% yield). lRMS (ESI) m/z 303 [M+H]+.

References

[1] Patent: JP5851663, 2016, B1. Location in patent: Paragraph 0303
[2] Patent: WO2004/58266, 2004, A1. Location in patent: Page/Page column 80

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate synthesis

Synthesis of tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate from 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate Preparation Products And Raw materials

Raw materials

1,2,4]Triazolo[4,3-a]pyrazine 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester 8-Chloro-[1,2,4]triazolo[4,3-a]pyrazine Chloroform Sodium bicarbonate

N-Bromosuccinimide

1of2

Preparation Products

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate Suppliers

Global Suppliers ( 128)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
China Langchem Inc.	0086-21-58956006		China	7798	57
skychemical Co.Ltd	021-20958197 20965099	sales@skychemical.com	China	1182	57
Shanghai Sphchem Co., Ltd.	021-56491756 13512199871	2819742715@qq.com	China	3994	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Shangchem Co., Ltd.	52
Pure Chemistry Scientific Inc.	62
Nanjing Chemlin Chemical Co., Ltd	64
China Langchem Inc.	57
skychemical Co.Ltd	57
Shanghai Sphchem Co., Ltd.	55

View Latest Price from tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-13	TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE 723286-80-4		1KG	98%; 99%	500g； 1kg; 25kg	Career Henan Chemical Co
	2019-12-27	TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE 723286-80-4	$1.00	1KG	99%	1000KGS	Career Henan Chemical Co

TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE
723286-80-4
$0.01
98%; 99%
Career Henan Chemical Co

TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE
723286-80-4
$1.00
99%
Career Henan Chemical Co

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate Spectrum

TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE(723286-80-4)¹HNMR

723286-80-4 (tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate) Related Search:

tert-Butyl 3-bromo-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 5,6,7,8-Tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester tert-Butyl formate

3-bromo-4-methyl-1,2,4-triazole

1of2

1,2,4-Triazolo[4,3-a]pyrazine-7(8H)-carboxylic acid, 3-bromo-5,6-dihydro-, 1,1-dimethylethyl ester Tert-butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8h)-carboxylate ,97% 7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine 3-Bromo-7-Boc-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 7-Boc-3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine 3-a]pyrazine-7(8H)-carboxylate tert-butyl 3-broMo-5 3-BroMo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylic acid tert-butyl ester 7-N-Boc-3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine tert-butyl 3-broMo-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate tert-butyl 3-bromo-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine... 7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4- 1,1-Dimethylethyl 3-bromo-5,6-dihydro-1,2,4-triazolo[4,3-a]pyrazine-7(8H)-carboxylate tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylat ert-Butyl 3-bromo-5,6-dihydro-1,2,4-triazolo[4,3-a]pyrazine-7(8H)-carboxylate tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 723286-80-4 C10H15BrN4O2 CHIRAL CHEMICALS