Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester

5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester

5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester Structure
5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester structure
CAS No.
723286-79-1
Chemical Name:
5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester
Synonyms
7-N-Boc-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine;7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine;tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H);5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate;tert-butyl 5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate;TERT-BUTYL 5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE;tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate ,99%;5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester;tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate hydrochloride;1,2,4-Triazolo[4,3-a]pyrazine-7(8H)-carboxylic acid, 5,6-dihydro-, 1,1-dimethylethyl ester
CBNumber:
CB82464558
Molecular Formula:
C10H16N4O2
Molecular Weight:
224.26
MDL Number:
MFCD10574958
MOL File:
723286-79-1.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:35
Request For Quotation

5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester Properties

Boiling point 378.4±52.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 2.87±0.20(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

HS Code  29349990

5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix B53202 tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 97% 723286-79-1 100mg $16 2026-05-06 Buy
Synthonix B53202 tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 97% 723286-79-1 250mg $22 2026-05-06 Buy
Synthonix B53202 tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 97% 723286-79-1 1g $50 2026-05-06 Buy
Synthonix B53202 tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 97% 723286-79-1 5g $180 2026-05-06 Buy
Ambeed A208098 tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 97% 723286-79-1 100mg $10 2026-06-05 Buy
Product number Packaging Price Buy
B53202 100mg $16 Buy
B53202 250mg $22 Buy
B53202 1g $50 Buy
B53202 5g $180 Buy
A208098 100mg $10 Buy

5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production

Chemical Properties

Off-white solid

Synthesis

8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

68774-77-6

Di-tert-butyl dicarbonate

24424-99-5

5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER

723286-79-1

8-Chloro-[1,2,4]triazolo[4,3-A]pyrazine (8.10 g) obtained in Step 2 was mixed with platinum (IV) oxide and 10% palladium/carbon (2 g, 50% aqueous content) in methanol (8 mL) and placed under a hydrogen atmosphere (50 psi, Parr unit) and stirred for 34 hours. Upon completion of the reaction, the reaction mixture was filtered through a Hyflo Super Cel and the filtrate was concentrated to give an oil. The oil was dissolved in dichloromethane (200 mL) and N,N-diisopropylethylamine (10 mL) and di-tert-butyl dicarbonate (11.4 g) were added sequentially and the reaction was stirred for 3 hours at room temperature. At the end of the reaction, saturated aqueous sodium bicarbonate solution was added and extracted with chloroform three times. The organic layers were combined, dried with anhydrous sodium sulfate and concentrated. The resulting crude product was purified by silica gel column chromatography to afford 7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine (2.55 g, 22% yield).

References

[1] Patent: JP5851663, 2016, B1. Location in patent: Paragraph 0302

5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

8-Chloro-[1,2,4]triazolo[4,3-a]pyrazine Di-tert-butyl dicarbonate N,N-Diisopropylethylamine Hydrogen Palladium
Platinum(IV) oxide

1of2

Preparation Products

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester Suppliers

Global Suppliers ( 75)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shangchem Co., Ltd. +86-21-68182121 China 881 52
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
skychemical Co.Ltd 021-20958197 20965099 sales@skychemical.com China 1182 57
QINGDAO CARELONGPHARMATECH CO.,LTD 053288191853 13061484198 sales@carelongchem.com China 455 57
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
JIANGYIN CANAL PHARMTECH CO.,LIMITED. +86-18921203887 sales@canalpharm.net China 288 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
PharmaBlock Sciences (Nanjing),Inc. 55
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shangchem Co., Ltd. 52
Tetranov Biopharm 64
skychemical Co.Ltd 57
QINGDAO CARELONGPHARMATECH CO.,LTD 57
Shanghai Topbiochem Technology Co., Ltd 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
JIANGYIN CANAL PHARMTECH CO.,LIMITED. 58

View Latest Price from 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER pictures 2019-12-26 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER
723286-79-1
 $1.00 1KG 99% 100KG Career Henan Chemical Co

5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester Spectrum

5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER(723286-79-1)1HNMR5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER(723286-79-1)1HNMR5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER(723286-79-1)13CNMR

723286-79-1 (5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester) Related Search:

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester 7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylic acid tert-Butyl 3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
tert-butyl 5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate TERT-BUTYL 5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate ,99% 7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate hydrochloride 7-N-Boc-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H) 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 1,2,4-Triazolo[4,3-a]pyrazine-7(8H)-carboxylic acid, 5,6-dihydro-, 1,1-dimethylethyl ester 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester 723286-79-1