ChemicalBook >> CAS DataBase List >>Bestatin hydrochloride

Bestatin hydrochloride

Bestatin hydrochloride structure

CAS No.: 65391-42-6

Chemical Name:: Bestatin hydrochloride

Synonyms: Bestatin.HCI;BESTATIN HCL;Ubenimex HCl;Ubenimex-d7 HCl;Ubenimex hydrochloride;HYDROCHLORIDE,Ubenimex;Bestatin HCl - Bio-X ?;Wufenmei Hydrochloride;Bestatin hydrochloride;Bestatin research grade

CBNumber:: CB2172341

Molecular Formula:: C16H25ClN2O4

Molecular Weight:: 344.83

MDL Number:: MFCD00058004

MOL File:: 65391-42-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:50:24

Request For Quotation

Bestatin hydrochloride Properties

Melting point	216-218 °C
storage temp.	2-8°C
solubility	H₂O: 25 mg/mL, clear, colorless
form	White to off-white powder.
color	White
biological source	synthetic (organic)
Water Solubility	Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
BRN	4628066
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20° for up to 1 month.
InChI	1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
InChIKey	XGDFITZJGKUSDK-UDYGKFQRSA-N
SMILES	O=C(N[C@@H](CC(C)C)C(O)=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1.Cl[H]
CAS DataBase Reference	65391-42-6(CAS DataBase Reference)
FDA UNII	BY7Y2JX7NQ
UNSPSC Code	12352202
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338
PPE	Eyeshields, Gloves, type N95 (US)
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	22-24/25-36-26
WGK Germany	3
F	3-10
HS Code	29242995
Storage Class	11 - Combustible Solids

Bestatin hydrochloride price More Price(74)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B8385	Bestatin hydrochloride ≥98% (HPLC)	65391-42-6	1mg	$84.9	2026-04-30	Buy
Sigma-Aldrich	B8385	Bestatin hydrochloride ≥98% (HPLC)	65391-42-6	5mg	$180	2026-04-30	Buy
Sigma-Aldrich	200488	Bestatin Hydrochloride InSolution, ≥98%, a metalloprotease inhibitor		10mg	$258	2026-04-30	Buy
Sigma-Aldrich	10874515001	Bestatin [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucinehydrochloride	65391-42-6	10mg	$244	2022-05-15	Buy
TCI Chemical	B4000	N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride >97.0%(HPLC)	65391-42-6	25mg	$142	2026-04-30	Buy

Product number	Packaging	Price	Buy
B8385	1mg	$84.9	Buy
B8385	5mg	$180	Buy
200488	10mg	$258	Buy
10874515001	10mg	$244	Buy
B4000	25mg	$142	Buy

Bestatin hydrochloride Chemical Properties, Uses, Production

Preparation

Bacillus subtilis Zj016 fermentation broth was centrifuged at 4 ℃ and 10,000 r/min for 10 min. The supernatant was collected and clarified with 18% (NH4)2SO4. The supernatant was then concentrated by ultrafiltration using a 50,000 molecular weight ultrafiltration membrane. The concentrate was desalted using a 30,000 molecular weight ultrafiltration membrane and precipitated with 68% ethanol. The precipitate was then freeze-dried under vacuum to obtain BESTATIN HYDROCHLORIDE with an activity of 4.0 × 105 U/g.

Description

Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor activity.

Uses

Bestatin Hydrochloride is an inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase. It is the salt form of Bestatin (B319500).

Uses

competitive aminopeptidase B inhibitor

Uses

Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

Uses

Bestatin has been used as a protease inhibitor for the purification of his-tagged Tau protein.

Definition

ChEBI: Bestatin (hydrochloride) is a peptide.

General Description

Chemical structure: amino acid derivatives

Biochem/physiol Actions

A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.

in vivo

in a mouse dorsal air sac assay, oral administration of bestatin (100-200 mg/kg/day) showed a significant inhibitory activity against the melanoma cell-induced angiogenesis. bestatin also inhibited the tube-like formation of human umbilical vein endothelial cells (huvecs). furthermore, after the orthotopic implantation of b16-bl6 melanoma cells into mice, bestatin administration (50-100 mg/kg/day, i.p) reduced the number of vessels oriented towards the established primary tumor mass on the dorsal side of mice [1].

References

[1] L. ORNING F A F Gwen G Krivi. Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes.[J]. The Journal of Biological Chemistry, 1991, 98 1: 1375-1378. DOI:10.1016/s0021-9258(18)52303-6
[2] XUEJIAN WANG. The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor.[J]. Biological & pharmaceutical bulletin, 2010, 33 10: 1658-1665. DOI:10.1248/bpb.33.1658

Bestatin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Bestatin hydrochloride Suppliers

Global Suppliers ( 197)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
AF Biochem Co., Ltd.	+86-028-60911900 13540204019	sales@afbiochem.com	China	479	57
TOKYO CHEMICAL INDUSTRY CO., LTD.	03-36680489	Sales-JP@TCIchemicals.com	Japan	28364	80
TCI Europe	320-37350700	sales@tcieurope.eu	Europe	23654	75
TCI AMERICA	800-4238616	sales@tciamerica.com	Americas	23636	75

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
LGM Pharma	70
Syntechem Co.,Ltd	57
AF Biochem Co., Ltd.	57
TOKYO CHEMICAL INDUSTRY CO., LTD.	80
TCI Europe	75
TCI AMERICA	75

View Latest Price from Bestatin hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	Bestatin hydrochloride 65391-42-6	$47.00-108.00		99.93%	10g	TargetMol Chemicals Inc.
2025-04-15	BESTATIN HYDROCHLORIDE 65391-42-6	$30.00	1kg	99%	5000kg/week	Hebei Zhuanglai Chemical Trading Co.,Ltd
2021-07-13	Bestatin hydrochloride 65391-42-6	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Bestatin hydrochloride
65391-42-6
$47.00-108.00
99.93%
TargetMol Chemicals Inc.

BESTATIN HYDROCHLORIDE
65391-42-6
$30.00
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

Bestatin hydrochloride
65391-42-6
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Bestatin hydrochloride Spectrum

BESTATIN HYDROCHLORIDE(65391-42-6)¹HNMR

65391-42-6 (Bestatin hydrochloride) Related Search:

N-Carbobenzoxy-DL-leucine α-Chymotrypsin Suc-Ala-Ala-Pro-Phe-SBzl Trypsin Carboxypeptidase B

Carboxypeptidase A 1,3-Diamino-2-propanol Betaine hydrochloride D(+)-Phenylalaninol Bestatin

N-(2-Hydroxyethyl)lactamide H-beta-Ala-NH2 HCl Diethanolamine hydrochloride 1,3-Dimethylbutylamine L-Leucine hydrochloride

(R)-(-)-4-Phenyl-2-butanol Bestatin hydrochloride H-beta-Ala-Ala-OH

1of4

N-[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE HYDROCHLORIDE N-(3R-AMINO-2S-HYDROXY-1-OXO-4-PHENYLBUTYL)-L-LEUCINE, MONOHYDROCHLORIDE [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HCL [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HYDROCHLORIDE (AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE HYDROCHLORIDE BESTATIN HCL N-(2S,3R-3-AMINO-2-HYDROXY-4-PHENYLBUTY- RYL)-L-LEUCINE HCL Bestatin.HCI N-(3-Amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine monohydrochloride (S)-2-((2S,3R)-3-aMino-2-hydroxy-4-phenylbutanaMido)-4-Methylpentanoic acid hydrochloride L-Leucine,N-[(2S,3R)-3-aMino-2-hydroxy-1-oxo-4-phenylbutyl]-, hydrochloride (1:1) Ubenimex Hydrochloride [for Biochemical Research] Ubenimex hydrochloride Bestatin research grade Bestatin-d7 HCl (Ubenimex-d7 HCl) Ubenimex-d7 HCl HYDROCHLORIDE,Ubenimex Bestatin hydrochloride, ≥98% (HPLC) N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride > BESTATIN HYDROCHLORIDE USP/EP/BP Ubenimex-d7 HClQ: What is Ubenimex-d7 HCl Q: What is the CAS Number of Ubenimex-d7 HCl (4S,5R)-5-amino-4-hydroxy-2-(2-methylpropyl)-3-oxo-6-phenyl-D-norleucine hydrochloride N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydrochloride (S)-2-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid hydrochloride[Ubenimex Hydrochloride Ubenimex HCl，Bestatin hydrochloride Ubenimex HCl Bestatin hydrochloride, aminopeptidase inhibitor Bestatin hydrochloride, 10 mM in DMSO Bestatin HCl - Bio-X ? Wufenmei Hydrochloride Bestatin hydrochloride 98% D7-Bestatin HCl (D7-Ubenimex HCl) Bestatin hydrochloride 65391-42-6 C16H24N2O4ClH C16HH24N2O4xHCL Antibiotics A-F Antibiotics A to Z Antibiotics BioChemical peptides Bestatin inhibitor Pepetides