Polyinosinic-polycytidylic acid sodium salt
- CAS No.
- 42424-50-0
- Chemical Name:
- Polyinosinic-polycytidylic acid sodium salt
- Synonyms
- polyinosinic-polycytidylic acid sodium;Poly (I:C) Na;Poly(I:C) sodium;POLY I POLY C, NA;Polymyocyte sodium salt;POLY[I] POLY[C] SODIUM SALT;polyI-polyC sodium salt compound solution;POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT;Polyinosinicacid-polycytidylicacidsodiumsal;POLYINOSINIC ACID POLYCYTIDYLIC ACID, SODIUM SALT
- CBNumber:
- CB2187556
- Molecular Formula:
- C19H27N7O16P2
- Molecular Weight:
- 671.41
- MDL Number:
- MFCD00131957
- MOL File:
- 42424-50-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | −20°C |
|---|---|
| solubility | H2O: soluble10mg/mL |
| form | lyophilized powder |
| color | White to off-white |
| biological source | synthetic (organic) |
| Water Solubility | Water : 10 mg/mL (Need ultrasonic and warming) |
| InChIKey | ACEVNMQDUCOKHT-WOQDZEJINA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r| |
| UNSPSC Code | 41106305 |
| NACRES | NA.51 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | TR0175000 |
| Storage Class | 11 - Combustible Solids |
Polyinosinic-polycytidylic acid sodium salt price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0913 | Polyinosinic–polycytidylic acid sodium salt ≥99% (less than 1% free nucleotides, TLC) | 42424-50-0 | 10mg | $148 | 2026-04-30 | Buy |
| Sigma-Aldrich | P0913 | Polyinosinic–polycytidylic acid sodium salt ≥99% (less than 1% free nucleotides, TLC) | 42424-50-0 | 50mg | $503 | 2026-04-30 | Buy |
| Sigma-Aldrich | 528906 | Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Stranded - CAS 42424-50-0 - Calbiochem Known to induce interferon production. Hypochromicity: ≥40% at 248 nm. Extinction coefficient = 5000 M-1cm-1 at 260 nm, pH 7.0. | 42424-50-0 | 10MG | $129 | 2026-04-30 | Buy |
| ChemScene | CS-0113922 | Polyinosinic-polycytidylic acid sodium 99.4% | 42424-50-0 | 5mg | $63 | 2026-06-04 | Buy |
| ChemScene | CS-0113922 | Polyinosinic-polycytidylic acid sodium 99.4% | 42424-50-0 | 10mg | $97 | 2026-06-04 | Buy |
Polyinosinic-polycytidylic acid sodium salt Chemical Properties, Uses, Production
Description
Polyinosinic-polycytidylic acid (Poly I:C) sodium salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist.
Uses
TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic-polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly I:C is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Biological Activity
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.
in vivo
Polyinosinic-polycytidylic acid (Poly I:C) treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid[1].
IC 50
TLR3
storage
Store at -20°C
Polyinosinic-polycytidylic acid sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU KAIPENG BIOTECHNOLOGY CO., LTD. | 0571-89939007 | kaipengbio@126.com | China | 10 | 58 |
| WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?) | 13282012786 13282132786 | sales@weitai-pharmaceutical.com | China | 69 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| Hubei XinyuanShun Chemical Co., Ltd. | 13971561712, 13995564702, 027-50664929 | hbeixys2001@163.com | China | 3110 | 55 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| Watson Biotechnology Co.,Ltd | 027-59207879 1972026995 18140587686 | sales@3600chem.com | China | 4175 | 55 |
View Latest Price from Polyinosinic-polycytidylic acid sodium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Polyinosinic-polycytidylic acid sodium salt
42424-50-0
|
1g | 45%-55% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-18 | Polyi polycytidylic acid sodium salt(Poly I:C) (PIC)
42424-50-0
|
1kg | ≥90% | 2tons | WeiTai BioPharmaceutical Co.,Ltd(Hangzhou) | ||
 |
2026-07-27 | Polyinosinic-polycytidylic acid sodium
42424-50-0
|
$30.00-73.00 | 10g | TargetMol Chemicals Inc. |
-
- Polyinosinic-polycytidylic acid sodium salt
42424-50-0
- $0.00
- 45%-55%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Polyi polycytidylic acid sodium salt(Poly I:C) (PIC)
42424-50-0
- ≥90%
- WeiTai BioPharmaceutical Co.,Ltd(Hangzhou)
-
- Polyinosinic-polycytidylic acid sodium
42424-50-0
- $30.00-73.00
- TargetMol Chemicals Inc.
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