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N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea

N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea structure

CAS No.: 445007-59-0

Chemical Name:: N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea

Synonyms: AK963;N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea

CBNumber:: CB21890260

Molecular Formula:: C16H18N2O

Molecular Weight:: 254.32692

MDL Number:

MOL File:: 445007-59-0.mol

MSDS File:: SDS

Last updated:2026-07-27 17:00:41

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N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
aablocks	AA024BI8	AK963/40708899 85%	445007-59-0	5mg	$123	2026-06-01	Buy
aablocks	AA024BI8	AK963/40708899 85	445007-59-0	50mg	$318	2026-06-01	Buy

Product number	Packaging	Price	Buy
AA024BI8	5mg	$123	Buy
AA024BI8	50mg	$318	Buy

N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea Chemical Properties, Uses, Production

Description

AK963, also known as 40708899, is a potent PAK1 (p21-activated kinase 1) inhibitor, which suppresses the proliferation of human gastric cancer cells significantly by downregulation of PAK1-NFκB-CyclinB1 pathway.

Uses

AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways[1].

IC 50

PAK1

References

[1] Ying Zhou, et al. Targeting PAK1 with the Small Molecule Drug AK963/40708899 Suppresses Gastric Cancer Cell Proliferation and Invasion by Downregulation of PAK1 Activity and PAK1-Related Signaling Pathways. Anat Rec (Hoboken). 2019 Sep;302(9):1571-1579. DOI:10.1002/ar.24095

N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea Suppliers

Global Suppliers ( 4)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
Shaoguan Qicheng Biotechnology Co., Ltd	18122215013	780229652@qq.com	China	1392	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shaoguan Qicheng Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58

View Latest Price from N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	AK963 445007-59-0	$1520.00-2500.00			10g	TargetMol Chemicals Inc.

AK963
445007-59-0
$1520.00-2500.00
TargetMol Chemicals Inc.

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N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea AK963 445007-59-0