Methyl 2,4-difluorobenzoate
- CAS No.
- 106614-28-2
- Chemical Name:
- Methyl 2,4-difluorobenzoate
- Synonyms
- 2,3-difluoro-4-methylbenzoate;RARECHEM AL BF 0213;Methyl 2,4-difluorobenzoate;Methyl2,4-Difluorobenzoate>Methyl 2,4-difluorobenzoate 97%;Methyl 2,4-difluorobenzoate ,97%;2,4-DIFLUORO-BENZOIC ACID METHYL ESTER;Benzoic acid, 2,4-difluoro-, methyl ester
- CBNumber:
- CB2198394
- Molecular Formula:
- C8H6F2O2
- Molecular Weight:
- 172.13
- MDL Number:
- MFCD03093799
- MOL File:
- 106614-28-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 128-129 °C (lit.) |
|---|---|
| Density | 1.384 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 180 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| InChI | InChI=1S/C8H6F2O2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3 |
| InChIKey | YQUHULOBTDYMAG-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(F)C=C1F |
| CAS DataBase Reference | 106614-28-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Methyl 2,4-difluorobenzoate price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 595047 | Methyl 2,4-difluorobenzoate 97% | 106614-28-2 | 5g | $66 | 2026-04-30 | Buy |
| TCI Chemical | M1879 | Methyl 2,4-Difluorobenzoate >98.0%(GC) | 106614-28-2 | 5g | $35 | 2026-04-30 | Buy |
| TCI Chemical | M1879 | Methyl 2,4-Difluorobenzoate >98.0%(GC) | 106614-28-2 | 25g | $114 | 2026-04-30 | Buy |
| Usbiological | 455013 | Methyl 2,4-Difluorobenzoate | 106614-28-2 | 5g | $305 | 2026-06-03 | Buy |
| Usbiological | 455013 | Methyl 2,4-Difluorobenzoate | 106614-28-2 | 10g | $418 | 2026-06-03 | Buy |
Methyl 2,4-difluorobenzoate Chemical Properties,Uses,Production
Chemical Properties
Colorless to yellow liquid
Uses
Methyl 2,4-Difluorobenzoate is a reagent used in the synthesis of pharmaceuticals. Used in the design and synthesis of integrin αvβ3 antagonists displaying antiplatelet activity.
Synthesis
1583-58-0
106614-28-2
General procedure for the synthesis of methyl 2,4-difluorobenzoate from 2,4-difluorobenzoic acid: 1. 2,4-difluorobenzoic acid (1.5808 g, 10.00 mmol) was dissolved in methanol (15 mL) and cooled to 0 °C in an ice-water bath. 2. a methanol (10 mL) solution of thionyl chloride (1.46 mL, 20.02 mmol) was added slowly and dropwise to the above cooled mixture. 3. Gradually warm the reaction mixture to room temperature with continuous stirring for 24 hours. 4. Upon completion of the reaction, the mixture was poured into saturated aqueous NaHCO3 solution and extracted three times with ether. 5. The organic phases were combined and dried over anhydrous MgSO4. 6. The organic phase was concentrated under pressure and purified by silica gel column chromatography (eluent: hexane/ether=5/1) to give methyl 2,4-difluorobenzoate (1.6743 g, 97% yield). 7. The product was characterized by 1H-NMR (CDCl3): δ 7.99 (td, 1H, J=8.2,6.6 Hz), 6.98-6.84 (m, 2H), 3.93 (s, 3H).
References
[1] Patent: US6194461, 2001, B1
Methyl 2,4-difluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Changzhou Tianrui Pharmaceutical Technology Co., Ltd. | 0519-85386832 13382812559 | sales@cztrchem.com | China | 1211 | 56 |
| Hangzhou Mingma Technology Co., LTD | 17621758100 | sales@sunmatech.com | China | 139 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
View Lastest Price from Methyl 2,4-difluorobenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | Methyl 2,4-difluorobenzoate
106614-28-2
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2026-02-02 | METHYL 2,4-DIFLUOROBENZOATE
106614-28-2
|
1g | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-06-27 | METHYL 2,4-DIFLUOROBENZOATE
106614-28-2
|
$10.00 | 1kg | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Methyl 2,4-difluorobenzoate
106614-28-2
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- METHYL 2,4-DIFLUOROBENZOATE
106614-28-2
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- METHYL 2,4-DIFLUOROBENZOATE
106614-28-2
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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