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4-Amino-3-chloro-benzoic acid ethyl ester

4-Amino-3-chloro-benzoic acid ethyl ester Structure
4-Amino-3-chloro-benzoic acid ethyl ester structure
CAS No.
82765-44-4
Chemical Name:
4-Amino-3-chloro-benzoic acid ethyl ester
Synonyms
AKOS BB-3099;4-amino-3-chloro-2-ethylbenzoate;4-AMINO-3-CHLORO-BENZOIC ACID ETHYL ESTER;Benzoic acid, 4-aMino-3-chloro-, ethyl ester;ethyl 4-amino-3-chlorobenzoate(SALTDATA: FREE);4-amino-3-chloro-Benzoic acid ethyl ester (9CI ACI);Benzoic acid, 4-amino-3-chloro-, ethyl ester (9CI, ACI)
CBNumber:
CB2206004
Molecular Formula:
C9H10ClNO2
Molecular Weight:
199.63
MDL Number:
MFCD06411007
MOL File:
82765-44-4.mol
MSDS File:
SDS
Last updated:2026-05-27 23:59:15
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4-Amino-3-chloro-benzoic acid ethyl ester Properties

Melting point 83-84°C
Boiling point 110-115 °C(Press: 0.001 Torr)
Density 1.262±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 0.56±0.10(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Flame (GHS02)
GHS07,GHS02
Signal word  Warning
Hazard statements  H315-H319-H226
Precautionary statements  P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
HS Code  2922498590

4-Amino-3-chloro-benzoic acid ethyl ester price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR346587 4-Amino-3-chlorobenzoic acid ethyl ester >98% 82765-44-4 1g $21 2026-06-04 Buy
Apolloscientific OR346587 4-Amino-3-chlorobenzoic acid ethyl ester >98% 82765-44-4 5g $33 2026-06-04 Buy
Apolloscientific OR346587 4-Amino-3-chlorobenzoic acid ethyl ester >98% 82765-44-4 25g $130 2026-06-04 Buy
Apolloscientific OR346587 4-Amino-3-chlorobenzoic acid ethyl ester >98% 82765-44-4 100g $487 2026-06-04 Buy
Matrix Scientific 180858 4-Amino-3-chlorobenzoic acid ethyl ester 82765-44-4 1.00g $60 2026-05-18 Buy
Product number Packaging Price Buy
OR346587 1g $21 Buy
OR346587 5g $33 Buy
OR346587 25g $130 Buy
OR346587 100g $487 Buy
180858 1.00g $60 Buy

4-Amino-3-chloro-benzoic acid ethyl ester Chemical Properties,Uses,Production

Uses

4-Amino-3-chloro-benzoic acid ethyl ester is used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

Benzocaine

94-09-7

4-Amino-3-chloro-benzoic acid ethyl ester

82765-44-4

To a solution of ethyl 4-aminobenzoate (2.0 mmol) in acetonitrile (2 mL) was added N-chlorosuccinimide (NCS, 2.05 mmol). The reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate and the organic layer was washed with 5% sodium hydroxide solution and subsequently dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give the crude product. Purification by recrystallization in hexane afforded ethyl 4-amino-3-chlorobenzoate (27c) as purple crystals (melting point 81-83 °C) in 86% yield. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) and 13C NMR (75 MHz, CDCl3): 1H NMR δ 1.33 (t, 3H, J=7.0 Hz, CH3), 4.29 (q, 2H, J=7.0 Hz, CH2), 6.70 (d, 1H, J=8.5 Hz, Ar-H), 7.72 (dd , 1H, J=8.4,1.9 Hz, Ar-H), 7.92 (d, 1H, J=1.9 Hz, Ar-H); 13C NMR δ 14.30, 60.62, 114.35, 118.06, 120.63, 129.52, 131.12, 146.97, 165.74.

References

[1] Organic Letters, 2008, vol. 10, # 1, p. 113 - 116
[2] Journal of the Brazilian Chemical Society, 2018, vol. 29, # 1, p. 109 - 124
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 27, p. 6973 - 6982
[4] Patent: US5502073, 1996, A
[5] Patent: US5516774, 1996, A

4-Amino-3-chloro-benzoic acid ethyl ester Preparation Products And Raw materials

Raw materials

Benzocaine Acetonitrile N-Chlorosuccinimide

Preparation Products

4-Amino-3-chloro-benzoic acid ethyl ester Suppliers

Global( 70)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
ShangHai YuanYe Biotechnology Co., Ltd. 15026964105 shyysw007@163.com China 4998 60
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
SynAsst Chemical. 021-60343070 China 12731 55
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9849 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Beijing FYF Chemicals Co., Ltd 010-57903446 15869909019 168931144@qq.com China 2876 58
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Zhengzhou Guancheng Laboratory equipment Sales 0371-88888888 qq272369594;2159423853qq 2723695949@qq.com China 4991 50
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
ShangHai YuanYe Biotechnology Co., Ltd. 60
Hangzhou Sage Chemical Co., Ltd. 58
SynAsst Chemical. 55
Amatek Scientific Co. Ltd. 55
Bide Pharmatech Ltd. 60
Beijing FYF Chemicals Co., Ltd 58
Cool Pharm, Ltd 58
Zhengzhou Guancheng Laboratory equipment Sales 50

4-Amino-3-chloro-benzoic acid ethyl ester Spectrum

4-Amino-3-chloro-benzoic acid ethyl ester(82765-44-4)1HNMR

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ethyl 4-amino-3-chlorobenzoate(SALTDATA: FREE) Benzoic acid, 4-aMino-3-chloro-, ethyl ester 4-AMINO-3-CHLORO-BENZOIC ACID ETHYL ESTER AKOS BB-3099 4-amino-3-chloro-2-ethylbenzoate Benzoic acid, 4-amino-3-chloro-, ethyl ester (9CI, ACI) 4-amino-3-chloro-Benzoic acid ethyl ester (9CI ACI) 82765-44-4