2-Methylindole-3-ethylamine
- CAS No.
- 2731-06-8
- Chemical Name:
- 2-Methylindole-3-ethylamine
- Synonyms
- 2-(2-METHYL-1H-INDOL-3-YL)ETHANAMINE;AKOS B006949;2-Methyltryptamin;RARECHEM AN KA 1106;ART-CHEM-BB B006949;2-METHYL TRYPTAMINE;2-Methyltryptamine>2-Methylindole-3-ethylamine;2-Methyltryptamine, ≥ 98.0%;3-(2-AMINOETHYL)-2-METHYLINDOLE
- CBNumber:
- CB2220730
- Molecular Formula:
- C11H14N2
- Molecular Weight:
- 174.24
- MDL Number:
- MFCD00130185
- MOL File:
- 2731-06-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 106.0 to 110.0 °C |
|---|---|
| Boiling point | 177°C/1.5mmHg(lit.) |
| Density | 1.126±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| pka | 17.78±0.30(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Dark green |
| InChI | InChI=1S/C11H14N2/c1-8-9(6-7-12)10-4-2-3-5-11(10)13-8/h2-5,13H,6-7,12H2,1H3 |
| InChIKey | CPVSLHQIPGTMLH-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2)C(CCN)=C1C |
| CAS DataBase Reference | 2731-06-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| HS Code | 2933.99.8290 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
2-Methylindole-3-ethylamine price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2055 | 2-Methyltryptamine >98.0%(GC)(T) | 2731-06-8 | 1g | $121 | 2026-04-30 | Buy |
| TCI Chemical | M2055 | 2-Methyltryptamine >98.0%(GC)(T) | 2731-06-8 | 5g | $366 | 2026-04-30 | Buy |
| Biosynth | FM25971 | 2-Methyltryptamine | 2731-06-8 | 1g | $224.88 | 2026-06-04 | Buy |
| Biosynth | FM25971 | 2-Methyltryptamine | 2731-06-8 | 2g | $374.82 | 2026-06-04 | Buy |
| Biosynth | FM25971 | 2-Methyltryptamine | 2731-06-8 | 5g | $674.65 | 2026-06-04 | Buy |
2-Methylindole-3-ethylamine Chemical Properties, Uses, Production
Chemical Properties
Brown Solid
Uses
Key starting material in the synthesis of the histone deacetylase inhibitor LBH589.
Synthesis
5891-21-4
100-63-0
2731-06-8
The general procedure for the synthesis of 2-methylindole-3-ethylamine from 5-chloro-2-pentanone and phenylhydrazine was as follows: phenylhydrazine (19.8 mL, 200 mmol) and anhydrous ethanol (120 mL) were added to a 500 mL three-necked flask, which was heated to 35 °C under N2 protection. Subsequently, a solution of 5-chloro-2-pentanone (210 mmol) in ethanol (25 mL) was added dropwise. After maintaining the reaction temperature at 40 °C with stirring for 30 min, 160 mL of ethanol was added and the reaction was slowly heated to reflux for 4 hours. Upon completion of the reaction, filtration was performed and the solvent was removed by evaporation. Water (50 mL) was added to the residue and the mixture was adjusted to acidity with 2M hydrochloric acid solution. It was extracted with ethyl acetate (50 mL x 2) and the organic phase was discarded. The aqueous phase was adjusted to alkaline with 20% NaOH solution and extracted again with ethyl acetate (50 mL x 2) and the organic phases were combined. The organic phase was washed with water (50 mL×2) and saturated sodium chloride solution (50 mL×2) sequentially, dried over anhydrous sodium sulfate, filtered and concentrated to obtain the red oily product 2-methylindole-3-ethylamine (24.2 g, 70.1% yield).
References
[1] Organic Letters, 2014, vol. 16, # 13, p. 3480 - 3483
[2] Organic Process Research and Development, 2008, vol. 12, # 6, p. 1078 - 1088
[3] Patent: CN108794375, 2018, A. Location in patent: Paragraph 0043-0045
[4] Patent: CN108752255, 2018, A. Location in patent: Paragraph 0027-0029
[5] Journal of Chemical Research, 2018, vol. 42, # 9, p. 471 - 473
2-Methylindole-3-ethylamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai joygo pharmacetical tech., Co., Ltd. | 13621615409 | sale1@joygooo.com | China | 108 | 50 |
| Wuhan FengyaoTonghui Chemical Products Co., Ltd. | 027-87466105 15377573527 | 2678564200@qq.com | China | 17968 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Latest Price from 2-Methylindole-3-ethylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-Methylindole-3-ethylamine
2731-06-8
|
$1.00 | 1kg | 95%-99% | 500kg | Career Henan Chemical Co |
-
- 2-Methylindole-3-ethylamine
2731-06-8
- $1.00
- 95%-99%
- Career Henan Chemical Co
