Etamsylate
- CAS No.
- 2624-44-4
- Chemical Name:
- Etamsylate
- Synonyms
- ETHAMSYLATE;Phenolsulfonate;e141;md141;eselin;HeMsyl;K-Stat;Sylate;altodor;aglumin
- CBNumber:
- CB5165128
- Molecular Formula:
- C10H17NO5S
- Molecular Weight:
- 263.31
- MDL Number:
- MFCD00867499
- MOL File:
- 2624-44-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 125° |
|---|---|
| Density | 1.3441 (rough estimate) |
| refractive index | 1.5060 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Very soluble in water, freely soluble in methanol, soluble in anhydrous ethanol, practically insoluble in methylene chloride. |
| form | Solid |
| color | White to Pale Red |
| Merck | 14,3722 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3 |
| InChIKey | HBGOLJKPSFNJSD-UHFFFAOYSA-N |
| SMILES | C1(S(=O)(=O)O)=CC(=CC=C1O)O.N(CC)CC |
| CAS DataBase Reference | 2624-44-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 24YL531VOH |
| ATC code | B02BX01 |
| EPA Substance Registry System | Ethamsylate (2624-44-4) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501 |
| WGK Germany | WGK 3 |
| RTECS | DB6145000 |
| TSCA | TSCA listed |
| HS Code | 2921.19.6190 |
| HazardClass | IRRITANT |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 i.v. in mice, rats: 800, 1350 mg/kg (Esteve) |
Etamsylate price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E1830000 | Etamsylate European Pharmacopoeia (EP) Reference Standard | 2624-44-4 | 10 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | E1830000 | Etamsylate European Pharmacopoeia (EP) Reference Standard | 2624-44-4 | e1830000 | $153 | 2024-03-01 | Buy |
| TCI Chemical | E1145 | Etamsylate >98.0%(HPLC)(T) | 2624-44-4 | 1g | $26 | 2026-04-30 | Buy |
| TCI Chemical | E1145 | Etamsylate >98.0%(HPLC)(T) | 2624-44-4 | 5g | $76 | 2026-04-30 | Buy |
| Usbiological | 011412 | Ethamsylate | 2624-44-4 | 50mg | $403 | 2026-06-03 | Buy |
Etamsylate Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
Haemostatic / Anti Coagulant
Uses
Hemostatic;prostaglandin synthesis inhibitor
Definition
ChEBI: Etamsylate is a sulfonic acid derivative and an organosulfur compound.
Biological Activity
Etamsylate is a haemostatic agent th at is used for the management of blood loss. Apparently etamsylate increases capillary wall resistance and platelet adhesives by inhibition of the biosynthesis of prostaglandins causing platelet disaggregation in a presence of vascular wound. Recent studies suggest th at etamsylate antagonizes anti-coagulant activity of heparin.
Mechanism of action
Etamsylate is an antihaemorrhagic and vasoprotective agent. It increases platelet adhesiveness and capillary vascular wall resistance, thereby reducing capillary exudation and blood loss.
Clinical Use
Short-term treatment of blood loss in menorrhagiaProphylaxis of surgical bleeding (unlicensed)
Side effects
Significant: Hypotension (parenteral). Rarely, severe hypersensitivity reaction, including anaphylaxis.
Blood and lymphatic system disorders: Parenteral: Rarely, neutropenia, agranulocytosis, thrombocytopenia.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain or discomfort.
General disorders and administration site conditions: Asthenia (parenteral). Rarely, fever.
Musculoskeletal and connective tissue disorders: Rarely, arthralgia.
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Rarely, thromboembolism (parenteral).
Synthesis
Nowadays, the production methods of etamsylate in the market are benzoquinone method, in which benzoquinone method is to pass sulfur dioxide in the solution of diethylamine, ethanol and water, and then make diethylamine sulfite salt, then add p-benzoquinone into diethylamine sulfite salt solution under low temperature, and then distill and recycle the ethanol under reduced pressure after the reaction is finished and precipitate out the crude product after cooling, and then add sodium bisulfite and activated carbon to decolorize it in the water or diluted ethanol and then refine it to obtain the product, the The disadvantages of the process are: due to the incomplete reaction of p-benzoquinone, coupled with the solubility of phenolsulfonyl ethylamine in water and ethanol, so that the product yield is low, generally not more than 40%, and p-benzoquinone is more expensive, the use of sulfur dioxide, there are problems such as absorption of the tail gas.
Also on the market is the use of chlorosulfonic acid as a sulfonation agent, before sulfonation so that p-benzoquinone and organic solvents azeotropic dehydration to anhydrous, but this method uses organic solvents, pollution of the environment, which in the process of sulfonation reaction of hydrogen chloride gas, pollution of the environment.
Metabolism
Etamsylate is excreted unchanged, mainly in the urine.
Etamsylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Londi Medical Technology Co., LTD | 0531-88996911 15628983711 | 3305202763@qq.com | China | 125 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
Related articles
- Etamsylate: Antihemorrhagic Activity, Heparin Antagonism & Veterinary Application
- Etamsylate enhances endothelial-platelet interactions, antagonizes heparin's hemorrhagic effects, and shows potential in veter....
- Nov 3,2025
View Latest Price from Etamsylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Etamsylate
2624-44-4
|
25KG | 99.0%~101.0%; BP2010 | 50tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-20 | Etamsylate USP/EP/BP
2624-44-4
|
$1.10 | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-04-10 | Etamsylate
2624-44-4
|
$2.00-5.00 | 99% hplc | 5000kg | Wuhan JiyunZen Tech Co., Ltd. |
-
- Etamsylate
2624-44-4
- $0.00
- 99.0%~101.0%; BP2010
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Etamsylate USP/EP/BP
2624-44-4
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Etamsylate
2624-44-4
- $2.00-5.00
- 99% hplc
- Wuhan JiyunZen Tech Co., Ltd.
